Are intravitreal bevacizumab and ranibizumab effective in a rat model of choroidal neovascularization?
Lu F, Adelman RA. Are intravitreal bevacizumab and ranibizumab effective in a rat model of choroidal neovascularization? Graefe's Archive For Clinical And Experimental Ophthalmology 2008, 247: 171. PMID: 18781316, DOI: 10.1007/s00417-008-0936-y.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAptamers, NucleotideBevacizumabChoroidal NeovascularizationDisease Models, AnimalDose-Response Relationship, DrugFluorescein AngiographyInjectionsLight CoagulationMacular DegenerationRanibizumabRatsRats, Inbred BNVascular Endothelial Growth Factor AVitreous BodyConceptsLeakage of CNVTreatment of CNVPegaptanib sodiumChoroidal neovascularizationIntravitreal injectionRat modelBackgroundVascular endothelial growth factorAnti-VEGF agentsEffect of bevacizumabAnti-VEGF medicationsBrown Norway ratsEndothelial growth factorNon-human primatesAngiography 1Histopathologic toxicityIntravitreal bevacizumabCNV leakageFluorescein angiographyLaser photocoagulationBevacizumabTherapeutic effectCNV lesionsRanibizumabDay 1Important stimulatorPredicting Response to Glaucoma Therapy in One Eye Based on Response in the Fellow Eye: The Monocular Trial
Chaudhary O, Adelman RA, Shields MB. Predicting Response to Glaucoma Therapy in One Eye Based on Response in the Fellow Eye: The Monocular Trial. JAMA Ophthalmology 2008, 126: 1216-1220. PMID: 18779480, DOI: 10.1001/archopht.126.9.1216.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaIntraocular pressureFellow eyesGlaucoma suspectsSecond eyeFirst eyeSame medicationRetrospective medical record reviewTrue therapeutic effectMedical record reviewOpen-angle glaucomaMedication regimenRecord reviewGlaucoma therapyTherapeutic effectDrug trialsBinocular treatmentMonocular trialMedicationsPatientsAbsolute changeEyesSubsequent responseFurther studiesTrials