2021
Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival
Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNon-small cell lung cancerOverall survivalCell lung cancerCancer DatabaseMedical recordsLung cancerProstate cancerBreast cancerPatient recordsComplete dataRetrospective cohort studyCohort studyCancer RegistryCommon cancerVariables of interestHigh prevalenceMAIN OUTCOMEPatientsClinical advancementReal-world data sourcesCancerPrevalenceSurvivalHeterogeneous differences
2019
National Trends in Healthcare-Associated Infections for Five Common Cardiovascular Conditions
Miller PE, Guha A, Khera R, Chouairi F, Ahmad T, Nasir K, Addison D, Desai NR. National Trends in Healthcare-Associated Infections for Five Common Cardiovascular Conditions. The American Journal Of Cardiology 2019, 124: 1140-1148. PMID: 31371062, PMCID: PMC7883647, DOI: 10.1016/j.amjcard.2019.06.029.Peer-Reviewed Original ResearchConceptsLength of stayCommon cardiovascular conditionCentral line-associated bloodstream infectionsCatheter-associated urinary tract infectionsLine-associated bloodstream infectionsUrinary tract infectionVentilator-associated pneumoniaClostridium difficile infectionCardiovascular conditionsTract infectionsBloodstream infectionsDifficile infectionOutcome of HAICoronary artery bypassTotal hospital chargesAcute myocardial infarctionSkilled care facilityHealthcare-Associated InfectionsValue-based careHospital mortalityArtery bypassCardiogenic shockHeart failurePropensity matchingAtrial fibrillation
2018
Readmissions of adults within three age groups following hospitalization for pneumonia: Analysis from the Nationwide Readmissions Database
Jain S, Khera R, Mortensen EM, Weissler JC. Readmissions of adults within three age groups following hospitalization for pneumonia: Analysis from the Nationwide Readmissions Database. PLOS ONE 2018, 13: e0203375. PMID: 30212485, PMCID: PMC6136736, DOI: 10.1371/journal.pone.0203375.Peer-Reviewed Original ResearchConceptsMiddle-aged adultsNationwide Readmissions DatabaseAge groupsPneumonia readmissionsIndex pneumonia hospitalizationPatterns of readmissionRate of readmissionRisk-adjusted analysisMultivariable regression modelsYears of ageRisk-adjustment modelsPneumonia hospitalizationsReadmission ratesPrimary diagnosisHigh burdenReadmissionReadmission eventsHospitalizationMean costInsurance payerPneumoniaPotential interventionsYoung adultsAdultsSubstantial rateComparison of Outcomes of Transfemoral Versus Transapical Approach for Transcatheter Aortic Valve Implantation
Kumar N, Khera R, Fonarow GC, Bhatt DL. Comparison of Outcomes of Transfemoral Versus Transapical Approach for Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2018, 122: 1520-1526. PMID: 30190074, DOI: 10.1016/j.amjcard.2018.07.025.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAge DistributionAged, 80 and overBlood TransfusionCohort StudiesDatabases, FactualFemaleHeart FailureHospital MortalityHumansLength of StayMalePacemaker, ArtificialPeripheral Vascular DiseasesPrevalencePropensity ScoreStrokeTranscatheter Aortic Valve ReplacementUnited StatesConceptsTranscatheter aortic valve implantationAcute kidney injuryTA-TAVI proceduresAortic valve implantationTF-TAVIHospital mortalityTA-TAVIPostoperative strokeTransapical approachValve implantationTAVI procedureTA TAVIReal-world patient populationTA-TAVI groupTF-TAVI groupPropensity-matched cohortPeripheral vascular diseasePropensity-matched pairsComparison of outcomesTF approachICD-9 procedureLower ratesTA approachKidney injuryBaseline characteristicsTrends in Use and Expenditures of Brand-name Atorvastatin After Introduction of Generic Atorvastatin
Warraich HJ, Salami JA, Khera R, Valero-Elizondo J, Okunrintemi V, Nasir K. Trends in Use and Expenditures of Brand-name Atorvastatin After Introduction of Generic Atorvastatin. JAMA Internal Medicine 2018, 178: 719-721. PMID: 29525818, PMCID: PMC5885171, DOI: 10.1001/jamainternmed.2018.0990.Peer-Reviewed Original Research
2017
Role of Hospital Volumes in Identifying Low-Performing and High-Performing Aortic and Mitral Valve Surgical Centers in the United States
Khera R, Pandey A, Koshy T, Ayers C, Nallamothu BK, Das SR, Drazner MH, Jessen ME, Kirtane AJ, Gardner TJ, de Lemos JA, Bhatt DL, Kumbhani DJ. Role of Hospital Volumes in Identifying Low-Performing and High-Performing Aortic and Mitral Valve Surgical Centers in the United States. JAMA Cardiology 2017, 2: 1322-1331. PMID: 29117319, PMCID: PMC5815001, DOI: 10.1001/jamacardio.2017.4003.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveBayes TheoremCoronary Artery BypassDatabases, FactualFemaleHeart Valve Prosthesis ImplantationHospital Bed CapacityHospital MortalityHospitals, High-VolumeHospitals, Low-VolumeHospitals, TeachingHumansMaleMiddle AgedMitral ValveMitral Valve AnnuloplastyQuality of Health CareUnited StatesConceptsSurgical aortic valve replacementRisk-standardized mortality ratesMV replacementHospital procedure volumeMV repair proceduresHospital volumeSurgical proceduresProcedure volumeMitral Valve Surgical ProceduresHospital risk-standardized mortality ratesHigh-volume tertilesHospital surgical volumeMV surgical proceduresRisk-standardized outcomesAortic valve replacementCoronary artery bypassLow-volume hospitalsGood surgical outcomeMedian annual volumeRisk-adjusted outcomesLowest volume tertileHospital performanceRepair proceduresSAVR proceduresArtery bypassAdministrative Codes for Capturing In-Hospital Cardiac Arrest
Khera R, Spertus JA, Starks MA, Tang Y, Bradley SM, Girotra S, Chan PS. Administrative Codes for Capturing In-Hospital Cardiac Arrest. JAMA Cardiology 2017, 2: 1275-1277. PMID: 28877294, PMCID: PMC5736791, DOI: 10.1001/jamacardio.2017.2904.Peer-Reviewed Original ResearchAdministrative Claims, HealthcareAgedAged, 80 and overCardiopulmonary ResuscitationDatabases, FactualElectric CountershockFemaleHeart ArrestHospitalizationHumansInformation Storage and RetrievalInternational Classification of DiseasesMaleMedicareRegistriesTachycardia, VentricularUnited StatesVentricular FibrillationVentricular FlutterContemporary Epidemiology of Heart Failure in Fee-For-Service Medicare Beneficiaries Across Healthcare Settings
Khera R, Pandey A, Ayers CR, Agusala V, Pruitt SL, Halm EA, Drazner MH, Das SR, de Lemos JA, Berry JD. Contemporary Epidemiology of Heart Failure in Fee-For-Service Medicare Beneficiaries Across Healthcare Settings. Circulation Heart Failure 2017, 10: e004402. PMID: 29129828, PMCID: PMC6057614, DOI: 10.1161/circheartfailure.117.004402.Peer-Reviewed Original ResearchMeSH KeywordsAdministrative Claims, HealthcareAgedAged, 80 and overAmbulatory CareCardiology Service, HospitalDatabases, FactualFee-for-Service PlansFemaleHealth Services Needs and DemandHeart FailureHumansIncidenceInsurance BenefitsMaleMedicareNeeds AssessmentPrevalencePrognosisTime FactorsUnited StatesConceptsIncident HFService Medicare beneficiariesMedicare beneficiariesStudy periodEpidemiology of HFHeart failure epidemicOutpatient care settingsHealth policy interventionsHF mortalityPrevalent HFHeart failureMean ageOutpatient settingOverall burdenCare settingsContemporary epidemiologyNew diagnosisInpatientsHealthcare settingsCohortEpidemiologyPatientsMortalityFirst yearPronounced decreaseWith Great Power Comes Great Responsibility
Khera R, Krumholz HM. With Great Power Comes Great Responsibility. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003846. PMID: 28705865, PMCID: PMC5728376, DOI: 10.1161/circoutcomes.117.003846.Peer-Reviewed Original Research
2016
Variation in Hospital Use and Outcomes Associated With Pulmonary Artery Catheterization in Heart Failure in the United States
Khera R, Pandey A, Kumar N, Singh R, Bano S, Golwala H, Kumbhani DJ, Girotra S, Fonarow GC. Variation in Hospital Use and Outcomes Associated With Pulmonary Artery Catheterization in Heart Failure in the United States. Circulation Heart Failure 2016, 9: e003226. PMID: 27780836, PMCID: PMC5123800, DOI: 10.1161/circheartfailure.116.003226.Peer-Reviewed Original ResearchMeSH KeywordsAgedArrhythmias, CardiacCase-Control StudiesCatheterization, Swan-GanzCerebrovascular DisordersCoronary Artery DiseaseDatabases, FactualDisease ManagementFemaleHeart ArrestHeart FailureHospital MortalityHospitalsHumansLength of StayLogistic ModelsMaleMiddle AgedMyocardial InfarctionOdds RatioPractice Patterns, Physicians'Propensity ScoreShock, CardiogenicUnited StatesConceptsPA catheterizationHeart failureCatheter useHospital useDiseases-Ninth Revision codesPropensity-matched analysisPulmonary artery catheterPulmonary artery catheterizationHospital-level variabilityHF hospitalizationHospital mortalityArtery catheterArtery catheterizationNumber of hospitalsPA catheterRevision codesPatient outcomesAcademic hospitalExcess mortalityOdds ratioOutcomes AssociatedCatheterizationInternational ClassificationHospitalMortality