2024
A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression
Oikonomou E, Holste G, Yuan N, Coppi A, McNamara R, Haynes N, Vora A, Velazquez E, Li F, Menon V, Kapadia S, Gill T, Nadkarni G, Krumholz H, Wang Z, Ouyang D, Khera R. A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression. JAMA Cardiology 2024, 9: 534-544. PMID: 38581644, PMCID: PMC10999005, DOI: 10.1001/jamacardio.2024.0595.Peer-Reviewed Original ResearchCardiac magnetic resonanceAortic valve replacementCardiac magnetic resonance imagingAV VmaxSevere ASAortic stenosisCohort studyPeak aortic valve velocityCohort study of patientsAortic valve velocityCohort of patientsTraditional cardiovascular risk factorsAssociated with faster progressionStudy of patientsCedars-Sinai Medical CenterAssociated with AS developmentCardiovascular risk factorsCardiovascular imaging modalitiesIndependent of ageModerate ASEjection fractionEchocardiographic studiesValve replacementRisk stratificationCardiac structure
2017
Role of Hospital Volumes in Identifying Low-Performing and High-Performing Aortic and Mitral Valve Surgical Centers in the United States
Khera R, Pandey A, Koshy T, Ayers C, Nallamothu BK, Das SR, Drazner MH, Jessen ME, Kirtane AJ, Gardner TJ, de Lemos JA, Bhatt DL, Kumbhani DJ. Role of Hospital Volumes in Identifying Low-Performing and High-Performing Aortic and Mitral Valve Surgical Centers in the United States. JAMA Cardiology 2017, 2: 1322-1331. PMID: 29117319, PMCID: PMC5815001, DOI: 10.1001/jamacardio.2017.4003.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveBayes TheoremCoronary Artery BypassDatabases, FactualFemaleHeart Valve Prosthesis ImplantationHospital Bed CapacityHospital MortalityHospitals, High-VolumeHospitals, Low-VolumeHospitals, TeachingHumansMaleMiddle AgedMitral ValveMitral Valve AnnuloplastyQuality of Health CareUnited StatesConceptsSurgical aortic valve replacementRisk-standardized mortality ratesMV replacementHospital procedure volumeMV repair proceduresHospital volumeSurgical proceduresProcedure volumeMitral Valve Surgical ProceduresHospital risk-standardized mortality ratesHigh-volume tertilesHospital surgical volumeMV surgical proceduresRisk-standardized outcomesAortic valve replacementCoronary artery bypassLow-volume hospitalsGood surgical outcomeMedian annual volumeRisk-adjusted outcomesLowest volume tertileHospital performanceRepair proceduresSAVR proceduresArtery bypassComparison of Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Chronic Kidney Disease
Kumar N, Khera R, Garg N, Echouffo-Tcheugui JB, Venkatraman A, Pandey A, Bhatt DL. Comparison of Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Chronic Kidney Disease. The American Journal Of Cardiology 2017, 121: 343-348. PMID: 29268936, DOI: 10.1016/j.amjcard.2017.10.029.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationDialysis-requiring acute kidney injuryAcute kidney injuryChronic kidney diseaseAortic valve replacementPostoperative strokeSAVR proceduresKidney diseaseHospital mortalityValve replacementTranscatheter Versus Surgical Aortic Valve ReplacementRate of AKIRetrospective cohort studySevere aortic stenosisCo-primary outcomesPropensity-matched pairsAortic valve implantationComparison of outcomesKidney injuryCohort studyValve implantationAortic stenosisMultivariate analysisPatients