2024
Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans.
Fischer I, Na P, Harpaz-Rotem I, Marx B, Pietrzak R. Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39480145, DOI: 10.4088/jcp.24m15465.Peer-Reviewed Original ResearchConceptsSubthreshold posttraumatic stress disorderPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersLifetime psychiatric disordersUS veteransUS military veteransSymptom-related distressStress disorderPsychiatric disordersSymptom clustersTreating veteransCriterion AMilitary veteransTraumatic eventsCognitive functionWorking case definitionMental healthCriterion FFunctional impairmentVeteransNationally representative sampleFunctional correlatesDisordersElevated oddsGreater oddsPsychological Resilience of Mental Health Workers During the Russia-Ukraine War: Implications for Clinical Interventions.
Kang H, Fischer I, Vus V, Kolyshkina A, Ponomarenko L, Chobanian A, Esterlis I, Pietrzak R. Psychological Resilience of Mental Health Workers During the Russia-Ukraine War: Implications for Clinical Interventions. The Primary Care Companion For CNS Disorders 2024, 26 PMID: 39441963, DOI: 10.4088/pcc.24m03761.Peer-Reviewed Original ResearchConceptsMental health workersPsychological resilienceHealth workersDistress scoresClinical interventionsMental health symptomsGreater resilienceAssociated with greater resilienceWar-related exposuresWork-related stressorsConvenience samplePsychosocial characteristicsHealth symptomsMeaning in lifeOccupational stressorsPresence of meaning in lifeOccupational stressSocial connectednessPromote resiliencePsychiatric resilienceGreater levelsInterventionScoresSocial relationshipsAuthor affiliationAmygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original ResearchAssociation patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Adhikari K, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchConceptsAntisocial personality disorderSubstance use disordersPersonality disorderUse disorderAssociation of antisocial personality disorderPresence of antisocial personality disorderPrevalence of antisocial personality disorderHazardous useDSM-5 SUD diagnosesSubstance use disorder severityDiagnostic criteriaInteraction effects with sexTobacco use disorderDSM-5Association of alcoholSUD diagnosisDisordersCocaineRacial/ethnic backgroundsIndividualsCocUDSeverityCannabisAssociation patternsAssociationMicroglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedoniaPsychological Factors, Physical Conditions, and Functioning Among US Veterans
Fischer I, Na P, Feldman D, Krist A, Kudler H, Jeste D, Pietrzak R. Psychological Factors, Physical Conditions, and Functioning Among US Veterans. JAMA Network Open 2024, 7: e2427382. PMID: 39120905, PMCID: PMC11316230, DOI: 10.1001/jamanetworkopen.2024.27382.Peer-Reviewed Original ResearchHelping the Helpers: Mental Health Challenges of Psychosocial Support Workers During the Russian-Ukrainian War
Kang H, Fischer I, Esterlis I, Kolyshkina A, Ponomarenko L, Chobanian A, Vus V, Pietrzak R. Helping the Helpers: Mental Health Challenges of Psychosocial Support Workers During the Russian-Ukrainian War. Disaster Medicine And Public Health Preparedness 2024, 18: e95. PMID: 38829179, DOI: 10.1017/dmp.2024.68.Peer-Reviewed Original ResearchConceptsPsychosocial support workersPosttraumatic stress disorderAssociated with greater oddsPresence of meaning in lifeMeaning in lifeSuicidal ideationMental health challengesGreater oddsMental healthLow optimismSupport workersHealth challengesMental health problemsCorrelates of burnoutPromote social connectednessStress disorderPsychosocial characteristicsGreater distressWar exposureGeneral populationHealth problemsSocial connectednessBurnoutOddsSocial relationshipsFunctional significance of posttraumatic growth in U.S. military veterans
Gower T, Fischer I, Tsai J, Kang H, Na P, Tedeschi R, Pietrzak R. Functional significance of posttraumatic growth in U.S. military veterans. Journal Of Affective Disorders 2024, 356: 267-273. PMID: 38614442, DOI: 10.1016/j.jad.2024.04.046.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPosttraumatic stress disorder symptomsPosttraumatic growthPsychosocial functioningTraumatic eventsTrauma-exposed U.S. veteransNational Health and ResilienceMale veteran samplePost-trauma functioningPattern of findingsRetrospective self-reportsU.S. military veteransVeteran sampleStress disorderVeterans StudyExamined relationsCross-sectional designMilitary veteransNationally representative sampleU.S. veteransAssociated with functionsPhysical functionClinical interventionsPsychosocial characteristicsVeterans
2020
Self‐reported exercise frequency and PTSD: results from the National Health and Resilience in Veterans Study
Adams T, Forte J, Fogle B, Southwick S, Pietrzak R. Self‐reported exercise frequency and PTSD: results from the National Health and Resilience in Veterans Study. Acta Psychiatrica Scandinavica 2020, 142: 486-495. PMID: 32961606, DOI: 10.1111/acps.13234.Peer-Reviewed Original ResearchConceptsProbable posttraumatic stress disorderPosttraumatic stress disorderSelf-reported exercise frequencyExercise frequencyNational HealthDaily exercisePhysical exerciseGreater severityVeterans StudyDays/weekMilitary veteransPopulation-based sampleAnxious arousal symptomsU.S. military veteransWeekly exerciseRe-experiencing symptomsU.S. veteransClinical implicationsProtective factorsStress disorderArousal symptomsCross-sectional dataPrevalenceSeverityVeteransPTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.Peer-Reviewed Original ResearchMeSH KeywordsAcetamidesAdaptor Proteins, Signal TransducingAdultBrainCase-Control StudiesFemaleGene Expression ProfilingHealthy VolunteersHumansMaleMicrogliaMiddle AgedPositron-Emission TomographyPyridinesRadiopharmaceuticalsReceptors, GABAReceptors, Tumor Necrosis Factor, Member 14Sex FactorsStress Disorders, Post-TraumaticYoung AdultConceptsPosttraumatic stress disorderPeripheral immune activationImmune activationHigher C-reactive protein levelsC-reactive protein levelsTSPO availabilityTranslocator proteinBrain microglial activationTomography brain imagingStress-related pathophysiologyPositron emission tomography (PET) brain imagingNeuroimmune activationMicroglial activationPTSD symptom severityImmunologic regulationPostmortem studiesPTSD subgroupHealthy individualsSymptom severityTrauma exposurePTSD groupStress disorderLower relative expressionBrain imagingPET imaging
2017
Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans.
Watkins LE, Han S, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans. The Journal Of Clinical Psychiatry 2017, 78: e1058-e1059. PMID: 29099554, DOI: 10.4088/jcp.17l11646.Peer-Reviewed Original Research
2014
Functional significance of a novel 7-factor model of DSM-5 PTSD symptoms: Results from the National Health and Resilience in Veterans Study
Pietrzak RH, Tsai J, Armour C, Mota N, Harpaz-Rotem I, Southwick SM. Functional significance of a novel 7-factor model of DSM-5 PTSD symptoms: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2014, 174: 522-526. PMID: 25556669, DOI: 10.1016/j.jad.2014.12.007.Peer-Reviewed Original ResearchConceptsQuality of lifePosttraumatic stress disorderDSM-5 PTSD symptomsPTSD symptomsNational HealthU.S. veteransSuicidal ideationVeterans StudySymptom clustersDysphoric arousal symptomsCross-sectional designFunctional outcomePsychiatric comorbidityClinical significancePTSD symptom clustersCurrent depressionDSM-5 PTSD symptom clustersPTSD phenotypeMental disordersSymptomsComorbid psychopathologyStress disorderFunctional correlatesStatistical ManualTreatment effortsPrediction of winning amateur boxers using pretournament reaction times.
Darby D, Moriarity J, Pietrzak R, Kutcher J, McAward K, McCrory P. Prediction of winning amateur boxers using pretournament reaction times. The Journal Of Sports Medicine And Physical Fitness 2014, 54: 340-6. PMID: 24739297.Peer-Reviewed Original Research
2011
Support for a novel five-factor model of posttraumatic stress symptoms in three independent samples of Iraq/Afghanistan veterans: A confirmatory factor analytic study
Pietrzak RH, Tsai J, Harpaz-Rotem I, Whealin JM, Southwick SM. Support for a novel five-factor model of posttraumatic stress symptoms in three independent samples of Iraq/Afghanistan veterans: A confirmatory factor analytic study. Journal Of Psychiatric Research 2011, 46: 317-322. PMID: 22154134, DOI: 10.1016/j.jpsychires.2011.11.013.Peer-Reviewed Original ResearchConceptsIraq/Afghanistan veteransHyperarousal symptom clustersConfirmatory factor analytic studyFactor analytic studiesAfghanistan veteransDysphoric arousalPTSD symptomsArousal clustersCommunity samplePosttraumatic stress disorder (PTSD) symptomsEmotional numbing modelSymptom clustersTreatment-seeking samplePosttraumatic stress symptomsDSM-IV modelIndependent samplesFive-factor modelConfirmatory factor analysisAnxious arousalEmotional numbingNumbing modelPTSD symptomatologyDisorder symptomsStress symptomsPTSD ChecklistMedical Comorbidity of Full and Partial Posttraumatic Stress Disorder in US Adults
Pietrzak RH, Goldstein RB, Southwick SM, Grant BF. Medical Comorbidity of Full and Partial Posttraumatic Stress Disorder in US Adults. Psychosomatic Medicine 2011, 73: 697-707. PMID: 21949429, PMCID: PMC3188699, DOI: 10.1097/psy.0b013e3182303775.Peer-Reviewed Original ResearchConceptsLifetime trauma exposureMedical conditionsUS adultsPartial PTSDTrauma exposureAngina pectorisStomach ulcersHuman immunodeficiency virus seropositivityNoncirrhotic liver diseaseDiagnosis of hypertensionPartial posttraumatic stress disorderWave 2 National Epidemiologic SurveyLogistic regression analysisPast-year diagnosesNational Epidemiologic SurveyNumerous medical conditionsPosttraumatic stress disorderIntermediate oddsMedical comorbiditiesDiabetes mellitusLiver diseaseVirus seropositivityHeart diseaseAxis IEpidemiologic Survey