2024
Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda
Nasuuna E, Tomlinson L, Kalyesubula R, Dziva Chikwari C, Castelnuovo B, Manabe Y, Nakanjako D, Weiss H. Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda. BMC Nephrology 2024, 25: 422. PMID: 39587464, PMCID: PMC11590532, DOI: 10.1186/s12882-024-03865-8.Peer-Reviewed Original ResearchConceptsAlbumin-creatinine ratioChronic kidney diseaseFactors associated with chronic kidney diseaseSerum creatinineAdjusted odds ratiosCystatin CKidney diseaseEarly diagnosisAssociated with chronic kidney diseasePrevalence of chronic kidney diseaseCompare serum creatinineCreatinine-based onesFactors of chronic kidney diseaseAssociated with high mortalityCases of chronic kidney diseaseDefinition of chronic kidney diseaseChronic kidney disease prevalenceCystatin C-based equationsCystatin C levelsEstimate adjusted odds ratiosMeasuring urinary albuminConfidence intervalsDiagnosis of chronic kidney diseaseMultivariate logistic regressionReduce disease progressionHigher prevalence of kidney function impairment among older people living with HIV in Uganda
Ssemasaazi A, Kalyesubula R, Manabe Y, Mbabazi P, Naikooba S, Ssekindi F, Nasuuna E, Byakika-Kibwika P, Castelnuovo B. Higher prevalence of kidney function impairment among older people living with HIV in Uganda. BMC Nephrology 2024, 25: 321. PMID: 39334034, PMCID: PMC11428404, DOI: 10.1186/s12882-024-03761-1.Peer-Reviewed Original ResearchConceptsKidney function impairmentChronic kidney diseaseAntiretroviral therapyOlder PLWHFunctional impairmentKidney functionKidney diseaseHIV-related inflammationProgression of kidney diseasePrevalence of proteinuriaMultivariate logistic regression modelBurden of chronic kidney diseaseMeasures of kidney functionDiagnosis of hypertensionCross-sectional studyConclusionsHIV infectionHIV-related clinical characteristicsClinical characteristicsInstitution of measuresLogistic regression modelsDiabetes mellitusFemale sexHIVProteinuriaPLWHDiagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study
Nasuuna E, Kalyesubula R, Tomlinson L, Castelnuovo B, Okello E, Chikwari C, Weiss H. Diagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study. BMJ Open 2024, 14: e083221. PMID: 39153770, PMCID: PMC11331864, DOI: 10.1136/bmjopen-2023-083221.Peer-Reviewed Original ResearchConceptsPositive POC testCross-sectional studyChronic kidney diseaseDiagnostic performancePoint-of-care testingKidney diseaseHIV clinicPOC testingPOC testsBody mass index <Albumin-creatinine ratioPositive predictive valueUrinary excretion rateDiagnosis of chronic kidney diseaseYoung peopleYears of ageTherapy to adultsYPLHIVUrine dipstickCreatinine ratioDiagnosis of albuminuriaLogistic regressionPrimary outcomeAlbuminuriaHIVCapacity for the management of kidney failure in the International Society of Nephrology Africa region: report from the 2023 ISN Global Kidney Atlas (ISN-GKHA)
Tannor E, Davidson B, Nlandu Y, Bagasha P, Bilchut W, Davids M, Diongole H, Ekrikpo U, Hafiz E, Ibrahim K, Kalyesubula R, Nalado A, Olanrewaju T, Onu U, Pereira-Kamath N, Sakajiki A, Salah M, Vincent L, Arruebo S, Bello A, Caskey F, Damster S, Donner J, Jha V, Johnson D, Levin A, Malik C, Nangaku M, Okpechi I, Tonelli M, Ye F, Ashuntantang G, Arogundade F, Authors R, Gawad M, Abderrahim E, Akl A, Amekoudi E, Amouzegar A, Awobusuyi J, Bakoush O, Chissico E, Cho Y, Coker J, Cullis B, Dahwa R, Darwish R, Davison S, Divyaveer S, Ethier I, Fagoonee K, Fofana A, Freercks R, Fung W, Gandzali-Ngabe P, Ghimire A, Gouda Z, Habyarimana O, Htay H, Wan D, Irish G, Ismail W, Jagne A, Jarraya F, Jindal K, Kabllo B, Kalebi A, Folefack F, Kelly D, Lalji R, Lomatayo B, Mah S, Abderraman G, McCulloch M, Mengistu Y, Moloi M, Mwaba C, Neuen B, Ngigi J, Niang A, Nyandwi J, Odeh E, Osman M, Le Grand Ouanekpone C, Petrova A, Ranivoharisoa E, Riaz P, Saad S, See E, Sokwala A, Solarin A, Sozio S, Houssani T, Kiswaya E, Tia W, Tiv S, Ts'enoli T, Tungsanga S, Ulasi I, Vanglist S, Viecelli A, Wadee S, Wainstein M, Wearne N, Yeung E, Zaidi D. Capacity for the management of kidney failure in the International Society of Nephrology Africa region: report from the 2023 ISN Global Kidney Atlas (ISN-GKHA). Kidney International Supplements 2024, 13: 12-28. PMID: 38618494, PMCID: PMC11010621, DOI: 10.1016/j.kisu.2024.01.002.Peer-Reviewed Original ResearchHealth care workforceManagement of peopleCare workforceHealth systemKidney careWorld Health Organization building blocksIncreased out-of-pocket costsChronic kidney disease preventionGlobal Kidney Health AtlasBurden of chronic kidney diseaseOut-of-pocket costsKidney disease preventionHealth information dataHealth care workersChronic kidney diseaseManagement of kidney failureCare deliveryKidney disease managementNondialysis chronic kidney diseaseCare workersCare financingHealth infrastructureDisease preventionService deliveryKidney diseaseHypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review
Hahka T, Slotkowski R, Akbar A, VanOrmer M, Sembajwe L, Ssekandi A, Namaganda A, Muwonge H, Kasolo J, Nakimuli A, Mwesigwa N, Ishimwe J, Kalyesubula R, Kirabo A, Berry A, Patel K. Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review. Circulation Research 2024, 134: 459-473. PMID: 38359096, PMCID: PMC10885774, DOI: 10.1161/circresaha.123.324077.Peer-Reviewed Original ResearchConceptsHypertensive disorders of pregnancyIncidence of hypertensive disorders of pregnancyCo-morbiditiesCardiovascular diseaseDisorders of pregnancyAwareness of hypertensionIndividual quality of lifeLong-term consequences of hypertensionRates of hypertensionPeripheral arterial diseaseLack of prevention programsQuality of lifeHypertensive disordersConsequences of hypertensionLives of womenDecrease morbidityTreatment strategiesUncontrolled hypertensionArtery diseaseKidney diseaseHypertensionPrevention programsKnowledge of causesHeart diseasePrevention strategies
2023
HIV and Associated TB: A Lethal Association for Kidney Health?
Kalyesubula R, Wearne N, Kubo M, Hussey N, Naicker S. HIV and Associated TB: A Lethal Association for Kidney Health? Seminars In Nephrology 2023, 43: 151470. PMID: 38245391, DOI: 10.1016/j.semnephrol.2023.151470.Peer-Reviewed Original ResearchHuman immunodeficiency virusKidney diseaseHIV/TB coinfectionAvoidance of drug-drug interactionsLower-middle-income countriesDrug dose adjustmentDecline of kidney functionKidney function monitoringDrug-drug interactionsMechanisms of kidney diseasesHIV/TB patientsLow-incomeDose adjustmentImmunodeficiency virusClinical presentationDiagnose CKDKidney transplantationKidney functionInfectious causesIncreased riskKidney healthGenetic susceptibilityFunction monitoringPatientsKidney