2011
Cocaine
Beech, R.D. and Sinha, R. (2011) “Cocaine” in Addiction Medicine: Science and Practice, Johnson, B.A. ed. (Springer, New York) pp. 397-416.Peer-Reviewed Original Research
2010
Increased peripheral blood expression of electron transport chain genes in bipolar depression
Beech RD, Lowthert L, Leffert JJ, Mason PN, Taylor MM, Umlauf S, Lin A, Lee JY, Maloney K, Muralidharan A, Lorberg B, Zhao H, Newton SS, Mane S, Epperson CN, Sinha R, Blumberg H, Bhagwagar Z. Increased peripheral blood expression of electron transport chain genes in bipolar depression. Bipolar Disorders 2010, 12: 813-824. PMID: 21176028, PMCID: PMC3076072, DOI: 10.1111/j.1399-5618.2010.00882.x.Peer-Reviewed Original ResearchConceptsBipolar disorderBipolar depressionPeripheral bloodDepressed subjectsGeneGo MetaCore softwarePeripheral blood expressionHealthy control subjectsReal-time reverse transcription-polymerase chain reactionEffects of medicationReverse transcription-polymerase chain reactionQuantitative real-time reverse transcription-polymerase chain reactionTranscription-polymerase chain reactionMitochondrial electron transport chainControl subjectsPolymerase chain reactionUnmedicated subjectsHealthy controlsBlood expressionBPD subjectsSpecific genetic pathwaysElectron transport chain genesMetaCore softwareA totalAltered expressionQRT-PCRCocaine
Beech R, Sinha R. Cocaine. 2010, 397-416. DOI: 10.1007/978-1-4419-0338-9_18.Peer-Reviewed Original ResearchCognitive behavior therapyBehavior therapyCocaine dependenceGeneral cognitive behavior therapyContingency managementRelapse prevention techniquesCompulsive drug seekingReward-related informationContingency management techniquesCocaine-taking behaviorConditions of challengeExecutive controlLong-term neuroadaptationsCocaine-related disordersDrug seekingCocaine useAdditional clinical attentionExtended abstinenceAnxiety disordersNeurobiological aspectsChronic cocaine useRegular cocaine useRelapse preventionPsychological symptomsNegative consequences
2009
Altered response to antidepressant treatment in FoxG1 heterozygous knockout mice
Kinsler R, Taylor MM, Flores NM, Leffert JJ, Beech RD. Altered response to antidepressant treatment in FoxG1 heterozygous knockout mice. Synapse 2009, 64: 169-171. PMID: 19852072, PMCID: PMC2789865, DOI: 10.1002/syn.20737.Peer-Reviewed Original ResearchConceptsAdult hippocampal neurogenesisTail suspension testDifferent rodent modelsHeterozygous knockout miceForkhead box protein G1Heterozygous null miceRole of Foxg1Phosphatidyl inositol 3 kinaseContextual fear learningMechanism of actionAntidepressant actionHippocampal neurogenesisNeurogenic propertiesSwim testMood disordersRodent modelsSuspension testAntidepressantsKnockout miceLittermate controlsBehavioral abnormalitiesNull miceNormal levelsFOXG1 geneAltered response
2005
The Role of Transcription Factors in the Biology of Depression
Beech R, Duman R. The Role of Transcription Factors in the Biology of Depression. 2005, 823-854. DOI: 10.1002/9783527619672.ch33.Peer-Reviewed Original Research