2017
Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD
Bushinsky DA, Hostetter T, Klaerner G, Stasiv Y, Lockey C, McNulty S, Lee A, Parsell D, Mathur V, Li E, Buysse J, Alpern R. Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD. Clinical Journal Of The American Society Of Nephrology 2017, 13: 26-35. PMID: 29102959, PMCID: PMC5753317, DOI: 10.2215/cjn.07300717.Peer-Reviewed Original ResearchConceptsSerum bicarbonateEnd of treatmentMetabolic acidosisTreatment groupsBaseline serum bicarbonateMean baseline eGFRMEq/LSignificant adverse effectsBaseline eGFRGastrointestinal eventsAdverse eventsFirst doseControlled TrialsHeart failurePatientsCKDBaseline levelsMean increaseAbstractTextUnit studiesAcidosisAdverse effectsPlaceboTreatmentDays
1995
Southwestern Internal Medicine Conference: Vasculitis—It’s Time To Reclassify
Alpern R. Southwestern Internal Medicine Conference: Vasculitis—It’s Time To Reclassify. The American Journal Of The Medical Sciences 1995, 309: 235-248. PMID: 7900748, DOI: 10.1097/00000441-199504000-00010.Peer-Reviewed Original ResearchConceptsCytoplasmic antibodiesCrescentic glomerulonephritisAnti-neutrophil cytoplasmic antibodiesAnti-myeloperoxidase antibodiesSmall vessel vasculitisSmall vesselsP-ANCAPulse steroidsC-ANCAMost patientsRenal biopsyVessel vasculitisPathophysiologic mechanismsPathologic confirmationMedium arteriesLarge arteriesVasculitisCombination of treatmentsCytotoxic agentsAntibodiesVasculitidesGlomerulonephritisArterySteroidsTreatment
1991
Contrasting Effects of Various Potassium Salts on Renal Citrate Excretion*
SAKHAEE K, ALPERN R, JACOBSON H, PAK C. Contrasting Effects of Various Potassium Salts on Renal Citrate Excretion*. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 396-400. PMID: 1899422, DOI: 10.1210/jcem-72-2-396.Peer-Reviewed Original ResearchConceptsCitrate clearanceAcid-base statusUrinary citratePotassium citrateRenal citrate excretionMeq/dayPotassium citrate treatmentWeeks of treatmentNet acid excretionCitraturic responseUrinary ammoniumOral administrationCitrate excretionAcid excretionPotassium chlorideUrinary bicarbonateCitrate treatmentAlkali loadPotassium bicarbonateClearanceML/minExcretionDaysTreatmentTitratable acid