1991
Inhibition of Na(+)-independent H+ pump by Na(+)-induced changes in cell Ca2+.
Hays SR, Alpern RJ. Inhibition of Na(+)-independent H+ pump by Na(+)-induced changes in cell Ca2+. The Journal Of General Physiology 1991, 98: 791-813. PMID: 1660062, PMCID: PMC2229082, DOI: 10.1085/jgp.98.4.791.Peer-Reviewed Original ResearchConceptsCell pH recoveryCell Ca2PH recoveryAcid loadPump activityRenal outer medullaryDelayed activationCell acidificationRapid cell acidificationUnits/minApical membraneCell pHSustained elevationFura-2Outer medullaryExtracellular Ca2Inner stripeIntracellular Ca2Steady-state cell pHSustained increaseDimethyl-BAPTAInitial suppressionSpike increasePhysiologic ratesMicrofilament-disrupting agentIncreased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy.
Preisig PA, Alpern RJ. Increased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy. The Journal Of General Physiology 1991, 97: 195-217. PMID: 1849958, PMCID: PMC2216475, DOI: 10.1085/jgp.97.2.195.Peer-Reviewed Original ResearchConceptsHyperfiltration groupChronic hyperfiltrationNa/H antiporterKidney weightCell hypertrophyHigher glomerular filtration rateNa/H antiporter activityH antiporterGlomerular filtration rateVivo microperfused rat proximal tubuleCell pHRat proximal tubuleSymporter activityFiltration rateProximal tubulesUltrafiltrate-like solutionHyperfiltrationSteady-state cell pHProtein feedingPeritubular perfusateDietary proteinParallel increaseUninephrectomyHypertrophyCell acidification
1990
Basolateral membrane Na(+)-independent Cl-/HCO3- exchange in the inner stripe of the rabbit outer medullary collecting tubule.
Hays SR, Alpern RJ. Basolateral membrane Na(+)-independent Cl-/HCO3- exchange in the inner stripe of the rabbit outer medullary collecting tubule. The Journal Of General Physiology 1990, 95: 347-367. PMID: 2307960, PMCID: PMC2216319, DOI: 10.1085/jgp.95.2.347.Peer-Reviewed Original ResearchConceptsInner stripePeritubular ClDistal nephron segmentsBasolateral membraneCell acidificationCell pHLuminal changesUrinary acidificationNephron segmentsPH-sensitive fluorescent dyeIndependent ClCell alkalinizationCO2/HCO3Peritubular pHVoltage clampTubulesTwo-thirdsRabbitsTotal replacementCell pH changes
1987
Basolateral membrane Na/base cotransport is dependent on CO2/HCO3 in the proximal convoluted tubule.
Krapf R, Alpern RJ, Rector FC, Berry CA. Basolateral membrane Na/base cotransport is dependent on CO2/HCO3 in the proximal convoluted tubule. The Journal Of General Physiology 1987, 90: 833-853. PMID: 2831294, PMCID: PMC2228880, DOI: 10.1085/jgp.90.6.833.Peer-Reviewed Original ResearchBasolateral membrane Cl/HCO3 exchange in the rat proximal convoluted tubule. Na-dependent and -independent modes.
Alpern RJ, Chambers M. Basolateral membrane Cl/HCO3 exchange in the rat proximal convoluted tubule. Na-dependent and -independent modes. The Journal Of General Physiology 1987, 89: 581-598. PMID: 2953859, PMCID: PMC2215917, DOI: 10.1085/jgp.89.4.581.Peer-Reviewed Original ResearchConceptsCl/HCO3 exchangeNa-free solutionHCO3- exchangePeritubular NaCell pHHCO3- transport mechanismsBasolateral membraneProximal tubulesCoupling of NaMammalian proximal tubuleMeq/Similar increaseAmbient ClExtracellular fluidTubulesNa dependenceCotransporterNa concentrationCl concentrationsCellsSimilar amounts
1985
Mechanism of basolateral membrane H+/OH-/HCO-3 transport in the rat proximal convoluted tubule. A sodium-coupled electrogenic process.
Alpern RJ. Mechanism of basolateral membrane H+/OH-/HCO-3 transport in the rat proximal convoluted tubule. A sodium-coupled electrogenic process. The Journal Of General Physiology 1985, 86: 613-636. PMID: 2999293, PMCID: PMC2228817, DOI: 10.1085/jgp.86.5.613.Peer-Reviewed Original ResearchConceptsUnits/minPeritubular pHHigh extracellular potassium concentrationCell pHSodium concentrationPotassium concentrationExtracellular potassium concentrationBasolateral membranePeritubular potassium concentrationCell depolarizationMeq/Sodium removalCell acidificationTubulesPeritubular fluidTotal absenceSitCellsRatsMinSodium