1993
Glucocorticoids stimulate Na+/H+ antiporter in OKP cells
Baum M, Cano A, Alpern RJ. Glucocorticoids stimulate Na+/H+ antiporter in OKP cells. American Journal Of Physiology 1993, 264: f1027-f1031. PMID: 8391752, DOI: 10.1152/ajprenal.1993.264.6.f1027.Peer-Reviewed Original ResearchConceptsOKP cellsProximal tubule acidificationEffect of dexamethasoneAntiporter activityTime-dependent stimulationM aldosteroneHemodynamic changesTubule acidificationSystemic administrationDependent pH recoveryDexamethasoneM dexamethasoneAcid loadStimulatory effectGlucocorticoidsPH recoveryStimulationPH-sensitive dyePresent studyMaximal velocityCellsDirect effectAldosteronePrevious studiesActivity
1991
Mechanism of Distal Acidification: Relevance to Distal RTA
Alpern R. Mechanism of Distal Acidification: Relevance to Distal RTA. 1991, 1184-1188. DOI: 10.1007/978-3-662-35158-1_119.Peer-Reviewed Original ResearchMinimal urinary pHH secretionUrinary pHDistal acidificationLuminal pHDistal Na deliveryPresence of hyperkalemiaCortical collecting tubuleDistal RTAHigher luminal pHTubule functionAcid secretionDistal nephronDisease processK secretionCollecting tubuleSecretionNa deliveryHCO3- exchangerAbnormal leakMinimal gradientH pumpHyperkalemiaAldosteroneMembrane ATP