316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway
FOSTER H, HO T, POTAPENKO E, CARDONE R, KIBBEY R, MERRINS M. 316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway. Diabetes 2022, 71 DOI: 10.2337/db22-316-or.Peer-Reviewed Original ResearchΒ-cell-specific deletionΒ-cell metabolismStrong genetic evidenceSense nutrientsNutrient-stimulated insulin secretionAppropriate insulin secretionSecretory pathwayPKM2 isoformGenetic evidenceInsulin secretory pathwayPKM isoformsPKM1PCK2Essential signalAmino acidsPKM2Pyruvate kinaseADP generationΒ-cell responseInitiation of Ca2Genetic deletionIsoform expressionΒ-cellsDeletionInsulin secretion