2003
Synthesis and Evaluation of B-, C-, and D-Ring-Substituted Estradiol Carboxylic Acid Esters as Locally Active Estrogens
Labaree DC, Zhang JX, Harris HA, O'Connor C, Reynolds TY, Hochberg RB. Synthesis and Evaluation of B-, C-, and D-Ring-Substituted Estradiol Carboxylic Acid Esters as Locally Active Estrogens. Journal Of Medicinal Chemistry 2003, 46: 1886-1904. PMID: 12723952, DOI: 10.1021/jm0204340.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveEsterasesEstersEstradiolEstradiol CongenersEstrogen Receptor alphaEstrogen Receptor betaFemaleHumansIn Vitro TechniquesKidneyLigandsMiceMicrosomesOrgan SizeOxidoreductasesRatsRats, Sprague-DawleyReceptors, EstrogenStructure-Activity RelationshipTumor Cells, CulturedUterusVaginaConceptsEstrogen receptorHormonal activityReceptor bindingAnalogues of estradiolEstrogen-sensitive genesEstrogen receptor bindingEstrogen-responsive genesEstrogenic actionIshikawa cellsEffective estrogenActive estrogensEstrogenHormonal actionDerivatives of estradiolEstradiolEstrogenic responsesSystemic actionReceptorsEstrogenic activityVivo assaysNonspecific esterasesSteroid nucleusSensitive genesActivitySteroid ring
1995
Distribution of occupied and unoccupied estrogen receptors in the rat brain: effects of physiological gonadal steroid exposure
Yuan H, Bowlby D, Brown T, Hochberg R, MacLusky N. Distribution of occupied and unoccupied estrogen receptors in the rat brain: effects of physiological gonadal steroid exposure. Endocrinology 1995, 136: 96-105. DOI: 10.1210/en.136.1.96.Peer-Reviewed Original ResearchGonadal steroid exposureUnoccupied estrogen receptorEstrogen receptorER occupancySteroid exposureLevels of circulating estradiolBed nucleus of the stria terminalisIn vitro autoradiographic methodOccupied estrogen receptorsBrain regionsTreatment of intact malesHypothalamic arcuate nucleusHypothalamic ventromedial nucleusTissue sectionsEndogenous gonadal steroidsPreovulatory estrogen surgeMessenger RNA levelsER binding capacityArcuate nucleusMale ratsBed nucleusVentromedial nucleusCirculating estradiolLabeled estrogenStria terminalis
1992
Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain.
Toran-Allerand CD, Miranda RC, Bentham WD, Sohrabji F, Brown TJ, Hochberg RB, MacLusky NJ. Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 4668-4672. PMID: 1316615, PMCID: PMC49144, DOI: 10.1073/pnas.89.10.4668.Peer-Reviewed Original ResearchConceptsLow-affinity nerve growth factor receptorNerve growth factor receptorGrowth factor receptorBasal forebrainCholinergic neuronsSame neuronsFactor receptorCholinergic marker enzyme choline acetyltransferaseGonadal steroid hormone estrogenBrain-derived neurotrophic factorPrimate basal forebrainRodent basal forebrainSteroid hormone estrogenEnzyme choline acetyltransferaseNerve growth factorSitu hybridization histochemistryEstrogen deficiencyNeurotrophic factorNeurotrophin-3Cholinergic functionCholine acetyltransferaseNeuronal survivalHormone estrogenEstrogen receptorClinical conditions
1989
The synthesis of 11 beta-methoxy-[16 alpha-123I] iodoestradiol and its interaction with the estrogen receptor in vivo and in vitro.
Zielinski JE, Larner JM, Hoffer PB, Hochberg RB. The synthesis of 11 beta-methoxy-[16 alpha-123I] iodoestradiol and its interaction with the estrogen receptor in vivo and in vitro. Journal Of Nuclear Medicine 1989, 30: 209-15. PMID: 2738649.Peer-Reviewed Original Research