2024
Immunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes
Huelsboemer L, Boroumand S, Kochen A, Dony A, Moscarelli J, Hauc S, Stögner V, Formica R, Pomahac B, Kauke-Navarro M. Immunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes. Frontiers In Transplantation 2024, 3: 1366243. PMID: 38993787, PMCID: PMC11235358, DOI: 10.3389/frtra.2024.1366243.Peer-Reviewed Original ResearchCMV infectionImmunosuppressive regimensImmunosuppressive strategiesTransplant recipientsIncidence of rejection episodesClinical CMV infectionTriple maintenance therapyIncidence of rejectionEpisodes of rejectionIndividualized immunosuppressive regimensEffective immunosuppressive therapySystematic reviewFace transplant patientsHand transplant recipientsHand transplantationFacial graftImmunosuppressive therapyMaintenance therapyRejection episodesFacial mucosaGraft lossGraft rejectionTherapy regimensTransplant patientsRenal failure
2023
Treatment of De Novo Renal Transplant Recipients With Calcineurin Inhibitor–free, Belatacept Plus Everolimus–based Immunosuppression
Peddi V, Marder B, Gaite L, Oberholzer J, Goldberg R, Pearson T, Yang H, Allamassey L, Polinsky M, Formica R. Treatment of De Novo Renal Transplant Recipients With Calcineurin Inhibitor–free, Belatacept Plus Everolimus–based Immunosuppression. Transplantation Direct 2023, 9: e1419. PMID: 36700062, PMCID: PMC9820789, DOI: 10.1097/txd.0000000000001419.Peer-Reviewed Original ResearchBiopsy-proven acute rejection rateAcute rejection ratesAcute rejectionITT populationMycophenolate mofetilDe novo renal transplant recipientsBiopsy-proven acute rejectionDe novo renal transplantHigher acute rejection ratesNovo renal transplant recipientsRabbit antithymocyte globulin inductionCalcineurin inhibitor-based immunosuppressionAntithymocyte globulin inductionLymphocyte-depleting inductionGood renal functionPosttransplant lymphoproliferative disorderRenal transplant recipientsPhase 2 studyGlomerular filtration rateUnexpected adverse eventsEpstein-Barr virusCorticosteroid withdrawalGlobulin inductionGraft lossMaintenance regimen
2018
Analysis of Biomarkers Within the Initial 2 Years Posttransplant and 5-Year Kidney Transplant Outcomes
Faddoul G, Nadkarni GN, Bridges ND, Goebel J, Hricik DE, Formica R, Menon MC, Morrison Y, Murphy B, Newell K, Nickerson P, Poggio ED, Rush D, Heeger PS. Analysis of Biomarkers Within the Initial 2 Years Posttransplant and 5-Year Kidney Transplant Outcomes. Transplantation 2018, 102: 673-680. PMID: 29189482, PMCID: PMC6018026, DOI: 10.1097/tp.0000000000002026.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkersChemokine CXCL9Enzyme-Linked Immunospot AssayFemaleGlomerular Filtration RateGraft RejectionGraft SurvivalHumansInterferon-gammaInterferon-gamma Release TestsKidneyKidney TransplantationMaleMiddle AgedNorth AmericaPredictive Value of TestsProspective StudiesRisk FactorsTime FactorsTreatment OutcomeConceptsEnzyme-linked immunosorbent spotGraft lossAcute cellular rejectionKidney allograft lossKidney transplant outcomesGlomerular filtration rateMultivariable logistic regressionAllograft lossCellular rejectionCXCL9 levelsUrinary CXCL9Year posttransplantTransplant outcomesImmunosorbent spotUnivariable analysisChemokine measurementsFiltration rateSurrogate markerClinical trialsLate outcomesOrgan transplantationT cellsInterferon gammaAnalysis of biomarkersLogistic regression
2016
Belatacept and Eculizumab for Treatment of Calcineurin Inhibitor-induced Thrombotic Microangiopathy After Kidney Transplantation: Case Report
Merola J, Yoo PS, Schaub J, Smith JD, Rodriguez-Davalos MI, Tichy E, Mulligan DC, Asch W, Formica R, Kashgarian M, Kulkarni S. Belatacept and Eculizumab for Treatment of Calcineurin Inhibitor-induced Thrombotic Microangiopathy After Kidney Transplantation: Case Report. Transplantation Proceedings 2016, 48: 3106-3108. PMID: 27932157, DOI: 10.1016/j.transproceed.2016.04.005.Peer-Reviewed Original ResearchConceptsCalcineurin inhibitorsHemolytic uremic syndromeThrombotic microangiopathyKidney transplantationUremic syndromeMinimization of CNIsAtypical hemolytic uremic syndromeWithdrawal of tacrolimusEarly graft lossFavorable clinical courseGraft dysfunctionGraft lossImmunosuppression strategiesUsual therapyClinical courseCase reportCTLA-4Endothelial reactionFrequent causeChallenging causeUncontrolled activationMonoclonal antibodiesCellular destructionMicroangiopathyComponent C5
2015
Association Between Organ Procurement Organization Social Network Centrality and Kidney Discard and Transplant Outcomes
Butala NM, King MD, Reitsma W, Formica RN, Abt PL, Reese PP, Parikh CR. Association Between Organ Procurement Organization Social Network Centrality and Kidney Discard and Transplant Outcomes. Transplantation 2015, 99: 2617-2624. PMID: 26102610, PMCID: PMC4668206, DOI: 10.1097/tp.0000000000000773.Peer-Reviewed Original ResearchConceptsKidney volumeKidney Donor Risk IndexLower kidney volumesDelayed graft functionDonor risk indexKidney transplant waitlistCold ischemia timeDeceased donor kidneysHigher kidney volumeGraft functionGraft lossTransplant recipientsOrgan acceptanceTransplant outcomesDonor kidneysPrimary outcomeWaitlist timeRecipient outcomesScientific RegistryPrimary exposureTransplant waitlistKidney discardMultivariable regressionTransplant NetworkKidney
2008
Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis
Yarlagadda SG, Coca SG, Formica RN, Poggio ED, Parikh CR. Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis. Nephrology Dialysis Transplantation 2008, 24: 1039-1047. PMID: 19103734, DOI: 10.1093/ndt/gfn667.Peer-Reviewed Original ResearchConceptsGraft survivalAcute rejectionPatient survivalGraft functionSystematic reviewHigher mean serum creatinineDelayed graft functionMean serum creatinineLong-term outcomesDGF groupGraft lossGraft outcomeRenal transplantationCommon complicationRenal functionSecondary outcomesSerum creatininePrimary outcomeKidney functionMean creatinineKidney donorsPatientsDetrimental associationDGFLiterature search