2023
The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J
Toyonaga T, Khattar N, Wu Y, Lu Y, Naganawa M, Gallezot J, Matuskey D, Mecca A, Pittman B, Dias M, Nabulsi N, Finnema S, Chen M, Arnsten A, Radhakrishnan R, Skosnik P, D’Souza D, Esterlis I, Huang Y, van Dyck C, Carson R. The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 51: 1012-1022. PMID: 37955791, DOI: 10.1007/s00259-023-06487-8.Peer-Reviewed Original ResearchSynaptic densityAge-related decreaseMagnetic resonance imagingBlood flowAge-related synaptic lossGray matter volume lossSynaptic density lossPositron emission tomography (PET) ligandSynaptic vesicle glycoprotein 2AVivo PET measurementsMedial occipital cortexGray matter volumeAge-related neurodegenerationGray matter regionsCognitive normal subjectsAge-related changesSynaptic lossNerve terminalsWide age rangeOccipital cortexTomography ligandNormal subjectsGM volumeAge-related functional lossesMatter volume
1992
PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy
Theodore W, Carson R, Andreasen P, Zametkin A, Blasberg R, Leiderman D, Rice K, Newman A, Channing M, Dunn B, Simpson N, Herscovitch P. PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy. Epilepsy Research 1992, 13: 129-139. PMID: 1334456, DOI: 10.1016/0920-1211(92)90068-5.Peer-Reviewed Original ResearchConceptsComplex partial seizuresEEG fociBasal gangliaTemporal lobeBrain regionsPotent opiate antagonistMesial temporal lobeCerebral blood flowOpiate receptor bindingEEG-video monitoringLateral temporal cortexLow specific bindingSpecific bindingPartial seizuresTime-activity dataKappa receptorsOpiate antagonistEpileptic focusHuman epilepsyFrontal cortexIndividual patientsOccipital lobeMean VTBlood flowBlood samplesDissociation of Object and Spatial Vision in Human Extrastriate Cortex: Age-Related Changes in Activation of Regional Cerebral Blood Flow Measured with [15 O]Water and Positron Emission Tomography
Grady C, Haxby J, Horwitz B, Schapiro M, Rapoport S, Ungerleider L, Mishkin M, Carson R, Herscovitch P. Dissociation of Object and Spatial Vision in Human Extrastriate Cortex: Age-Related Changes in Activation of Regional Cerebral Blood Flow Measured with [15 O]Water and Positron Emission Tomography. Journal Of Cognitive Neuroscience 1992, 4: 23-34. PMID: 23967855, DOI: 10.1162/jocn.1992.4.1.23.Peer-Reviewed Original ResearchRegional cerebral blood flowCerebral blood flowSuperior parietal cortexOlder subjectsParietal cortexBlood flowYoung subjectsPositron emission tomographic scansDissociation of ObjectOccipitotemporal cortexOlder male subjectsVisual cortical areasMore activationHuman extrastriate cortexPositron emission tomographyAge-related reductionAge-related changesTomographic scanCortical areasBrain areasMale subjectsVisual pathwayEmission tomographyExtrastriate cortexCortex
1991
Dissociation of object and spatial visual processing pathways in human extrastriate cortex.
Haxby JV, Grady CL, Horwitz B, Ungerleider LG, Mishkin M, Carson RE, Herscovitch P, Schapiro MB, Rapoport SI. Dissociation of object and spatial visual processing pathways in human extrastriate cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 1621-1625. PMID: 2000370, PMCID: PMC51076, DOI: 10.1073/pnas.88.5.1621.Peer-Reviewed Original ResearchConceptsExtrastriate cortexRegional cerebral blood flowDissociation of ObjectPrimate extrastriate cortexCerebral blood flowHealthy young menExtrastriate visual pathwaysHuman extrastriate cortexPositron emission tomographyAnterior temporal cortexSuperior parietal cortexLateral occipital cortexNew cortical areasSensorimotor control taskVisual extrastriate cortexBolus injectionOccipital cortexBlood flowCortical areasTemporal cortexNeuroanatomical locationVisual pathwayParietal cortexVisual processing pathwayEmission tomography
1985
Quantitative measurement of myocardial blood flow with oxygen-15 water and positron computed tomography: an assessment of potential and problems.
Huang SC, Schwaiger M, Carson RE, Carson J, Hansen H, Selin C, Hoffman EJ, MacDonald N, Schelbert HR, Phelps ME. Quantitative measurement of myocardial blood flow with oxygen-15 water and positron computed tomography: an assessment of potential and problems. Journal Of Nuclear Medicine 1985, 26: 616-25. PMID: 3873525.Peer-Reviewed Original Research
1983
Quantitative Measurement of Local Cerebral Blood Flow in Humans by Positron Computed Tomography and 15O-Water
Huang S, Carson RE, Hoffman EJ, Carson J, MacDonald N, Barrio JR, Phelps ME. Quantitative Measurement of Local Cerebral Blood Flow in Humans by Positron Computed Tomography and 15O-Water. Cerebrovascular And Brain Metabolism Reviews 1983, 3: 141-153. PMID: 6601663, DOI: 10.1038/jcbfm.1983.21.Peer-Reviewed Original Research