2010
Effects of Hypoxia-Inducible Factor-1α Overexpression in Pregnant Mice Possible Implications for Preeclampsia and Intrauterine Growth Restriction
Tal R, Shaish A, Barshack I, Polak-Charcon S, Afek A, Volkov A, Feldman B, Avivi C, Harats D. Effects of Hypoxia-Inducible Factor-1α Overexpression in Pregnant Mice Possible Implications for Preeclampsia and Intrauterine Growth Restriction. American Journal Of Pathology 2010, 177: 2950-2962. PMID: 20952590, PMCID: PMC2993274, DOI: 10.2353/ajpath.2010.090800.Peer-Reviewed Original ResearchConceptsIntrauterine growth restrictionHIF-1αControl micePregnant miceGrowth restrictionFetal intrauterine growth restrictionSoluble vascular endothelial growth factor receptor-1Vascular endothelial growth factor receptor 1Serum sFlt-1Elevated liver enzymesLiver enzyme levelsMicroangiopathic hemolytic anemiaPregnancy-specific disorderHypoxia-inducible factor-1αComplete blood countGestational day 8Growth factor receptor 1HIF-1α overexpressionFactor receptor 1Hypoxia-inducible factorPlacental weightPregnant controlsSoluble endoglinBlood pressureSignificant anemia
2008
Endothelial-targeted gene transfer of hypoxia-inducible factor-1alpha augments ischemic neovascularization following systemic administration.
Tal R, Shaish A, Rofe K, Feige E, Varda-Bloom N, Afek A, Barshack I, Bangio L, Hodish I, Greenberger S, Peled M, Breitbart E, Harats D. Endothelial-targeted gene transfer of hypoxia-inducible factor-1alpha augments ischemic neovascularization following systemic administration. Molecular Therapy 2008, 16: 1927-36. PMID: 18797451, DOI: 10.1038/mt.2008.191.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factor-1alphaSystemic administrationTherapeutic efficacyProangiogenic gene therapyFactor-1alphaSystemic side effectsEnhanced blood perfusionRoute of administrationTail vein administrationHindlimb ischemia modelMouse hindlimb ischemia modelMurine preproendothelin-1 promoterClinical outcomesPreproendothelin-1 promoterC57BL/6 miceIschemic neovascularizationIntravenous routeIschemic muscleIntraarterial routeIschemia modelCapillary densityIschemic regionSide effectsSystemic toxicityTherapeutic angiogenesis