2017
Ancestry‐specific and sex‐specific risk alleles identified in a genome‐wide gene‐by‐alcohol dependence interaction study of risky sexual behaviors
Polimanti R, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Ancestry‐specific and sex‐specific risk alleles identified in a genome‐wide gene‐by‐alcohol dependence interaction study of risky sexual behaviors. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2017, 174: 846-853. PMID: 28990359, PMCID: PMC5861711, DOI: 10.1002/ajmg.b.32604.Peer-Reviewed Original ResearchS100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours
Polimanti R, Meda SA, Pearlson GD, Zhao H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours. Journal Of Psychiatry And Neuroscience 2017, 42: 252-261. PMID: 28418321, PMCID: PMC5487272, DOI: 10.1503/jpn.160189.Peer-Reviewed Original ResearchConceptsRisky sexual behaviorCAD diagnosisLow-frequency fluctuation (ALFF) analysisMultiple sexual partnersLeft paracentral lobuleSexual behaviorAfrican American cohortSemi-Structured AssessmentALFF analysisSexual functionAfrican American participantsCalcium-binding proteinsParacentral lobuleIndependent cohortRight pallidumCalcium homeostasisUnprotected sexCannabis dependenceDrug dependenceSignificant associationBrain regionsSexual partnersFrequency fluctuation analysisPrevious genome-wide association studyCohort
2016
The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene
Polimanti R, Wang Q, Meda SA, Patel KT, Pearlson GD, Zhao H, Farrer LA, Kranzler HR, Gelernter J. The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene. Neuropsychopharmacology 2016, 42: 598-605. PMID: 27531626, PMCID: PMC5240175, DOI: 10.1038/npp.2016.153.Peer-Reviewed Original ResearchConceptsRisky sexual behaviorAlcohol dependenceLow-frequency fluctuation (ALFF) analysisLeft superior frontal gyrusMultiple sexual partnersDSM-IV criteriaSexual behaviorMagnetic Resonance Imaging AnalysisAnterior cingulate regionsSuperior frontal gyrusMonetary incentive delay taskLifetime alcohol dependenceIncentive delay taskRight amygdalaClinical relevanceSTD riskUnprotected sexBrain circuitryFunctional magnetic resonance imaging (fMRI) analysisCingulate regionsSexual partnersFrequency fluctuation analysisFrontal gyrusGenetic findingsReduced activation