2023
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders
Hatoum A, Colbert S, Johnson E, Huggett S, Deak J, Pathak G, Jennings M, Paul S, Karcher N, Hansen I, Baranger D, Edwards A, Grotzinger A, Tucker-Drob E, Kranzler H, Davis L, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg H, Bogdan R, Agrawal A. Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders. Nature Mental Health 2023, 1: 210-223. PMID: 37250466, PMCID: PMC10217792, DOI: 10.1038/s44220-023-00034-y.Peer-Reviewed Original ResearchGenome-wide associationGenetic risk lociIndependent single nucleotide polymorphismsProblematic tobacco useSingle nucleotide polymorphismsRisk lociHigh polygenicityLociReceptor geneAddiction risk factorsPolygenic risk scoresEuropean descentPolygenicityGenesSummary statisticsSubstance use disordersSomatic conditionsAncestryRegulationConfersUse disordersPolymorphismGenetic liabilityDopamine regulationPDE4B
2021
Posttraumatic stress disorder: from gene discovery to disease biology
Polimanti R, Wendt FR. Posttraumatic stress disorder: from gene discovery to disease biology. Psychological Medicine 2021, 51: 2178-2188. PMID: 33583458, PMCID: PMC8364573, DOI: 10.1017/s0033291721000210.Peer-Reviewed Original ResearchConceptsGenome-wide associationEpigenome-wide associationComplex traitsGene discoveryAncestral diversityMorphological similarityHeritable riskDisease biologyDiverse numberBiologyWide arrayTranscriptomicsCertain traumatic eventsTraitsDiversityComplex mental disorderHighest conditional riskPopulationFuture studiesDiscovery