2017
Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
Chen C, Gu P, Wu J, Chen X, Niu S, Sun H, Wu L, Li N, Peng J, Shi S, Fan C, Huang M, Wong CC, Gong Q, Kumar-Sinha C, Zhang R, Pusztai L, Rai R, Chang S, Lei M. Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer. Nature Communications 2017, 8: 14929. PMID: 28393832, PMCID: PMC5394241, DOI: 10.1038/ncomms14929.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsConserved SequenceDNA DamageDNA Mutational AnalysisDNA RepairGenomic InstabilityHumansMiceModels, MolecularMolecular ChaperonesMutationNeoplasmsPhosphoproteinsProstaglandin-E SynthasesProtein BindingProtein Structure, SecondaryScattering, Small AngleShelterin ComplexStructure-Activity RelationshipTelomere-Binding ProteinsX-Ray DiffractionConceptsTelomerase-mediated telomere extensionHuman cancersDNA damage responseC-terminal mutationsOB foldsHuman POT1Chromosome endsGenome instabilityPOT1-TPP1Telomere extensionDamage responseStable heterodimerA-NHEJStructural insightsC-terminusInappropriate repairTPP1POT1Heart-shaped structureMissense mutationsTerminal portionMutationsDomainMutantsTelomeresCytogenetic Analysis of Telomere Dysfunction
Rai R, Multani AS, Chang S. Cytogenetic Analysis of Telomere Dysfunction. Methods In Molecular Biology 2017, 1587: 127-131. PMID: 28324504, DOI: 10.1007/978-1-4939-6892-3_12.Peer-Reviewed Original Research
2016
TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
Rai R, Chen Y, Lei M, Chang S. TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions. Nature Communications 2016, 7: 10881. PMID: 26941064, PMCID: PMC4785230, DOI: 10.1038/ncomms10881.Peer-Reviewed Original ResearchConceptsRepressor/activator protein 1Telomere length controlTranscriptional gene regulationRepair of telomeresTelomere end protectionNon-homologous endActivator protein-1Myb domainChromosome fusionsYeast Rap1Gene regulationHDR pathwayEnd protectionBasic domainTelomere lossTelomeresHuman cellsHR factorsProtein 1Length controlPARP1Free fusionInappropriate processingTRF2Important role
2006
BRIT1/MCPH1: A Guardian of Genome and an Enemy of Tumors
Chaplet M, Rai R, Jackson-Bernitsas D, Li K, Lin SY. BRIT1/MCPH1: A Guardian of Genome and an Enemy of Tumors. Cell Cycle 2006, 5: 2579-2583. PMID: 17172830, DOI: 10.4161/cc.5.22.3471.Peer-Reviewed Original ResearchConceptsDNA damageTiming of mitosisDNA damage checkpointDNA damage responseCell cycle checkpointsGuardian of genomePotential tumor suppressorDamage checkpointEukaryotic cellsIntriguing proteinNuclear fociGenomic stabilityDamage responseCycle checkpointsBRIT1Damage sensorTumor suppressorCellular responsesSophisticated mechanismsCancer initiationCentrosomal abnormalitiesNeoplastic transformationGenomeProteinImportant molecules
2004
Genome wide instability scanning in chewing-tobacco associated oral cancer using inter simple sequence repeat PCR
Rai R, Kulkarni V, Saranath D. Genome wide instability scanning in chewing-tobacco associated oral cancer using inter simple sequence repeat PCR. Oral Oncology 2004, 40: 1033-1039. PMID: 15509495, DOI: 10.1016/j.oraloncology.2004.05.009.Peer-Reviewed Original ResearchConceptsOral cancerTumor tissueNormal tissuesOral cancer patientsTumor-adjacent normal tissuesOral cancer samplesAdjacent normal tissuesMultiple tumor tissuesCancer patientsNormal tissue DNATumor progressionCancer samplesGenomic instability indexCancerTissue DNAGenomic alterationsTumor heterogeneityGenomic instabilityTissue