2020
Characterization of circulating and cultured Tfh-like cells in sickle cell disease in relation to red blood cell alloimmunization status
Balbuena-Merle R, Santhanakrishnan M, Devine L, Gibb DR, Tormey CA, Siddon AJ, Curtis SA, Gallagher PG, Weinstein JS, Hendrickson JE. Characterization of circulating and cultured Tfh-like cells in sickle cell disease in relation to red blood cell alloimmunization status. Transfusion And Apheresis Science 2020, 59: 102778. PMID: 32439490, PMCID: PMC7483805, DOI: 10.1016/j.transci.2020.102778.Peer-Reviewed Original ResearchConceptsTfh-like cellsNaïve CD4 T cellsSickle cell diseaseCD4 T cellsCD4 T cell subsetsT cell subsetsT cellsCell diseaseRed blood cell alloimmunizationPeripheral blood mononuclear cellsBlood mononuclear cellsCD3/CD28Electronic medical recordsAlloimmunization statusHLA alloantibodiesRBC autoantibodiesRBC alloantibodiesFollicular helperIL-12Mononuclear cellsMedical recordsIL-7Antigen specificityB cellsAlloantibodies
2019
Red blood cell alloimmunization and delayed hemolytic transfusion reactions in patients with sickle cell disease
Balbuena-Merle R, Hendrickson JE. Red blood cell alloimmunization and delayed hemolytic transfusion reactions in patients with sickle cell disease. Transfusion Clinique Et Biologique 2019, 26: 112-115. PMID: 30857806, DOI: 10.1016/j.tracli.2019.02.003.Peer-Reviewed Original ResearchConceptsHemolytic transfusion reactionsSickle cell diseaseRed blood cell alloimmunizationRBC alloantibodiesTransfusion reactionsRBC alloimmunizationCell diseaseLife-threatening hemolytic transfusion reactionsSubset of patientsBlood bank testingCurrent screening practicesAlternative complement pathwayRBC autoantibodiesTransfusion burdenInflammatory statusPatient populationCase reportRBC exposureBlood donorsScreening practicesHigh prevalenceChronic hemolysisAlloantibodiesBystander hemolysisPatients