The association between the amino acid transporter LAT1, tumor immunometabolic and proliferative features and menopausal status in breast cancer
Ramshankar G, Liu R, Perry R. The association between the amino acid transporter LAT1, tumor immunometabolic and proliferative features and menopausal status in breast cancer. PLOS ONE 2023, 18: e0292678. PMID: 37819900, PMCID: PMC10566702, DOI: 10.1371/journal.pone.0292678.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsFemaleHumansLarge Neutral Amino Acid-Transporter 1MenopausePositron Emission Tomography Computed TomographyPositron-Emission TomographyPrognosisConceptsL-type amino acid transporter 1Menopausal statusPrognostic effectLAT1 expressionBreast cancerTumor proliferationAmino acid transporter LAT1Immune cell infiltrationHigh LAT1 expressionAmino acid transporter 1Worse patient outcomesKaplan-Meier modelBreast cancer prognosisPatient survival probabilityPositron emission tomography-computed tomography (PET-CT) imagesSpecific essential amino acidsClinical factorsClinical parametersCell infiltrationPatient outcomesSystemic metabolismCancer prognosisBody compositionProliferative featuresCancer types