2019
Increased Diet Quality is Associated with Long‐Term Reduction of Abdominal and Pericardial Fat
Hennein R, Liu C, McKeown NM, Hoffmann U, Long MT, Levy D, Ma J. Increased Diet Quality is Associated with Long‐Term Reduction of Abdominal and Pericardial Fat. Obesity 2019, 27: 670-677. PMID: 30825267, PMCID: PMC6430652, DOI: 10.1002/oby.22427.Peer-Reviewed Original ResearchConceptsMediterranean-style diet scoreLess fat accumulationGenetic risk scoreFat accumulationDiet qualityAdipose tissueAbdominal subcutaneous adipose tissueEctopic fat depotsEctopic fat accumulationGenetic riskFramingham Heart Study participantsVisceral adipose tissuePericardial adipose tissueSubcutaneous adipose tissueDiet scorePericardial fatLong-term reductionRisk scoreFat depotsAdiposity profilesStudy participantsSD improvementFavorable changesLongitudinal associationsLongitudinal improvementA Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease
Ma J, Nano J, Ding J, Zheng Y, Hennein R, Liu C, Speliotes EK, Huan T, Song C, Mendelson MM, Joehanes R, Long MT, Liang L, Smith JA, Reynolds LM, Ghanbari M, Muka T, van Meurs JBJ, Alferink LJM, Franco OH, Dehghan A, Ratliff S, Zhao W, Bielak L, Kardia SLR, Peyser PA, Ning H, VanWagner LB, Lloyd-Jones DM, Carr JJ, Greenland P, Lichtenstein AH, Hu FB, Liu Y, Hou L, Murad S, Levy D. A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease. Diabetes 2019, 68: 1073-1083. PMID: 30936141, PMCID: PMC6477898, DOI: 10.2337/db18-1193.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseHepatic fatDNA methylation signaturesLiver diseasePopulation-based cohort studyMethylation signaturesNew-onset T2DType 2 diabetesHepatic fat accumulationMendelian randomization analysisCohort studyPotential causal pathwaysRisk factorsFat accumulationAfrican ancestry participantsEuropean ancestry participantsAttractive biomarkerCytosine-guanine dinucleotidesAssociation of hypomethylationWhole bloodHispanic ancestryRandomization analysisSame CpGsCausal pathways
2018
Improved Diet Quality Associates With Reduction in Liver Fat, Particularly in Individuals With High Genetic Risk Scores for Nonalcoholic Fatty Liver Disease
Ma J, Hennein R, Liu C, Long MT, Hoffmann U, Jacques PF, Lichtenstein AH, Hu FB, Levy D. Improved Diet Quality Associates With Reduction in Liver Fat, Particularly in Individuals With High Genetic Risk Scores for Nonalcoholic Fatty Liver Disease. Gastroenterology 2018, 155: 107-117. PMID: 29604292, PMCID: PMC6035111, DOI: 10.1053/j.gastro.2018.03.038.Peer-Reviewed Original ResearchConceptsMediterranean-style diet scoreNonalcoholic fatty liver diseaseAlternative Healthy Eating IndexGenetic risk scoreHigh genetic risk scoreDiet quality changesIncident fatty liverFatty liver diseaseLiver fat accumulationFatty liverDiet scoreLiver fatRisk scoreFramingham Heart StudyAHEI scoreLiver diseaseFat accumulationHeart StudyHarvard Food Frequency QuestionnaireDiet qualityFood frequency questionnaireThird Generation cohortsHealthy Eating IndexAssociation of changesStandard deviation increase