Biological functions of Mycobacterium tuberculosis-specific CD4+T cells were impaired by tuberculosis pleural fluid
Li Q, Li L, Liu Y, Fu X, Wang H, Lao S, yang B, Wu C. Biological functions of Mycobacterium tuberculosis-specific CD4+T cells were impaired by tuberculosis pleural fluid. Immunology Letters 2011, 138: 113-121. PMID: 21549757, DOI: 10.1016/j.imlet.2011.03.008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAmino Acid SequenceAntibodies, NeutralizingAntigens, BacterialBacterial ProteinsBody FluidsCD4-Positive T-LymphocytesCells, CulturedFemaleHumansInterferon-gammaInterleukin-10Interleukin-2LungLymphocyte ActivationMaleMiddle AgedMolecular Sequence DataMonocytesMycobacterium tuberculosisTransforming Growth Factor betaTuberculosis, PleuralTumor Necrosis Factor-alphaConceptsPleural fluid mononuclear cellsPleural fluidAntigen-specific cellular immune responsesFluid mononuclear cellsIFN-γ productionMycobacterium tuberculosis infectionCellular immune responsesProduction of IFNT cell functionDose-dependent mannerTuberculosis patientsIL-10Tuberculosis infectionTuberculosis pleurisyCytokine productionMononuclear cellsIL-2Activation moleculeImmune responseCell activation processCFSE labelingCell activationFunctional predominanceCell activityStrong inhibitory effectPleural fluid from tuberculous pleurisy inhibits the functions of T cells and the differentiation of Th1 cells via immunosuppressive factors
Li Q, Li L, Liu Y, Fu X, Qiao D, Wang H, Lao S, Huang F, Wu C. Pleural fluid from tuberculous pleurisy inhibits the functions of T cells and the differentiation of Th1 cells via immunosuppressive factors. Cellular & Molecular Immunology 2011, 8: 172-180. PMID: 21258363, PMCID: PMC4003141, DOI: 10.1038/cmi.2010.80.Peer-Reviewed Original ResearchConceptsT cell functionT cellsIL-10Tuberculosis pleurisyTh1 cellsLocal immune statusCourse of diseaseTumor necrosis factorTh1 cell differentiationGrowth factor-β1Inhibitor of indoleamineImmunosuppressive mediatorsEffect of PFImmunosuppressive factorsCytokine productionImmune statusTuberculous pleurisyPleural fluidImmunopathological factorsFactor-β1Cell activationPleurisyGrowth factorCell cycle progressionCycle progression[Analysis of ESAT-6-specific multifunctional CD4+; T cells in pleural fluid from patients with tuberculous pleurisy].
Li L, Qiao D, Li Q, Zhang X, Lao S, Wu C. [Analysis of ESAT-6-specific multifunctional CD4+; T cells in pleural fluid from patients with tuberculous pleurisy]. Chinese Journal Of Cellular And Molecular Immunology 2011, 27: 26-8. PMID: 21208559.Peer-Reviewed Original ResearchConceptsRecombinant ESAT-6 proteinT cellsESAT-6 proteinCytokine productionMean fluorescence intensityPeptide poolsTB infectionIL-2Positive cellsTh1 cytokine productionSingle-positive cellsTriple-positive cellsTuberculous pleurisyESAT-6Cell levelSingle-cell levelFlow cytometrySimilar frequencyStimulationCytokinesIFNTNFInfectionBCGCells