2009
Protease activation during in vivo pancreatitis is dependent on calcineurin activation
Shah AU, Sarwar A, Orabi AI, Gautam S, Grant WM, Park AJ, Shah AU, Liu J, Mistry PK, Jain D, Husain SZ. Protease activation during in vivo pancreatitis is dependent on calcineurin activation. AJP Gastrointestinal And Liver Physiology 2009, 297: g967-g973. PMID: 20501444, PMCID: PMC2777459, DOI: 10.1152/ajpgi.00181.2009.Peer-Reviewed Original ResearchConceptsAcinar cellsProtease activationDependent phosphatase calcineurinHourly intraperitoneal injectionsCourse of pancreatitisAcinar cell vacuolizationCholecystokinin analogue caeruleinPhosphatase calcineurinHistological severityMyeloperoxidase activityPancreatic acinar cellsAcute pancreatitisIL-6Inhibitor FK506Pancreatic edemaSerum amylaseIntraperitoneal injectionPancreatitis inductionPancreatitis severityCalcineurin activationPancreatitisPathological riseCell vacuolizationDigestive proenzymesPremature activation
1998
Ulcerative colitis has an aggressive course after orthotopic liver transplantation for primary sclerosing cholangitis
Papatheodoridis GV, Hamilton M, Mistry PK, Davidson B, Rolles K, Burroughs AK. Ulcerative colitis has an aggressive course after orthotopic liver transplantation for primary sclerosing cholangitis. Gut 1998, 43: 639. PMID: 9824344, PMCID: PMC1727300, DOI: 10.1136/gut.43.5.639.Peer-Reviewed Original ResearchConceptsPrimary sclerosing cholangitisInflammatory bowel diseaseLong-term steroidsUlcerative colitisSclerosing cholangitisBowel diseaseLiver transplantationAggressive courseTerm steroidsDe novo ulcerative colitisNew-onset ulcerative colitisInflammatory bowel disease activityBowel disease activityOnset ulcerative colitisOrthotopic liver transplantationEarly colorectal neoplasmsMaintenance immunosuppressionQuiescent courseDisease activityTransplant patientsPrevious colectomyColorectal cancerColorectal neoplasmsColitisPatients