2006
DNA damage and mismatch repair pathway in lung ischemia and reperfusion injury
Bonde P, Gao D, Chen L, Moreno-Vinasco L, Jacobson J, Garcia J, Wei C. DNA damage and mismatch repair pathway in lung ischemia and reperfusion injury. Journal Of Cardiothoracic-Renal Research 2006, 1: 147-152. DOI: 10.1016/j.jccr.2006.05.007.Peer-Reviewed Original ResearchLung ischemiaLung transplantationReperfusion groupReperfusion injuryWestern blotDNA mismatch repair pathwayAdult Sprague-Dawley ratsMismatch repair pathwaySprague-Dawley ratsModel of ischemiaAttractive therapeutic interventionCaspase-3 immunohistochemistryDNA damageCaspase-3 levelsDawley ratsLung tissueOxidative DNA damageReperfusionDNA repair enzymeIschemiaTherapeutic interventionsImmunohistochemistryRepair pathwaysProtein levelsTransplantation
2005
56 ATTENUATION OF RODENT LUNG ISCHEMIA/REPERFUSION INJURY BY SPHINGOSINE 1-PHOSPHATE
Moreno-Vinasco L, Bonde P, Jacobson J, Garcia J. 56 ATTENUATION OF RODENT LUNG ISCHEMIA/REPERFUSION INJURY BY SPHINGOSINE 1-PHOSPHATE. Journal Of Investigative Medicine 2005, 53: s366. DOI: 10.2310/6650.2005.00206.55.Peer-Reviewed Original ResearchIschemia/reperfusion injuryR injuryMyeloperoxidase activityLung transplantationReperfusion injuryVascular permeabilityAlbumin concentrationLung ischemia/reperfusion injuryLung tissue myeloperoxidase activityBronchoalveolar lavage cell countsLavage cell countsLung preservation techniquesPulmonary artery ligationR lung injuryTissue myeloperoxidase activityTime of reperfusionPeriod of reperfusionLung vascular permeabilityPotential therapeutic roleSprague-Dawley ratsImproved patient outcomesNovel therapeutic interventionsProfound clinical implicationsAlveolar damageDonor lungs