Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity.
Rosenkranz-Weiss P, Sessa WC, Milstien S, Kaufman S, Watson CA, Pober JS. Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity. Journal Of Clinical Investigation 1994, 93: 2236-2243. PMID: 7514193, PMCID: PMC294374, DOI: 10.1172/jci117221.Peer-Reviewed Original ResearchConceptsHuman umbilical vein endothelial cellsNitric oxide synthaseIL-1 betaNOS activityTetrahydrobiopterin levelsUmbilical vein endothelial cellsVein endothelial cellsEndothelial cellsIFN-gammaCytokine treatmentEndothelial nitric oxide synthaseTotal NOS activityNitric oxide synthesisCultured human endothelial cellsCytokine-treated cellsNitric oxide releaseGTP cyclohydrolase I activityHuman endothelial cellsProinflammatory cytokinesInflammatory cytokinesIntracellular tetrahydrobiopterin levelsOxide synthaseCytokine regulationRate-limiting enzymeOxide synthesisGender-specific Differences in Expression mRNAs for Functional and Structural Proteins in Rat Ventricular Myocardium
Rosenkranz-Weiss P, Tomek R, Mathew J, Eghbali M. Gender-specific Differences in Expression mRNAs for Functional and Structural Proteins in Rat Ventricular Myocardium. Journal Of Molecular And Cellular Cardiology 1994, 26: 261-270. PMID: 8006987, DOI: 10.1006/jmcc.1994.1029.Peer-Reviewed Original ResearchConceptsGene expressionMale rat heartsSex-related differencesAbundance of mRNAFemale heartsCytoskeletal actinRat heartCardiac fibroblastsFemale ratsDifferential gene expressionMale heartsMRNA levelsDNA synthesisExpression of genesAdult male rat heartsAge-matched male ratsCollagen type INewborn female ratsBeta-myosin heavy chainCultured cardiac fibroblastsFemale rat heartsRat ventricular myocardiumFunctional proteinsPost-pubertal periodSignificant sex-related differences