2021
Persistent Exertional Intolerance After COVID-19 Insights From Invasive Cardiopulmonary Exercise Testing
Singh I, Joseph P, Heerdt PM, Cullinan M, Lutchmansingh DD, Gulati M, Possick JD, Systrom DM, Waxman AB. Persistent Exertional Intolerance After COVID-19 Insights From Invasive Cardiopulmonary Exercise Testing. CHEST Journal 2021, 161: 54-63. PMID: 34389297, PMCID: PMC8354807, DOI: 10.1016/j.chest.2021.08.010.Peer-Reviewed Original ResearchConceptsInvasive cardiopulmonary exercise testingCardiopulmonary exercise testingCardiopulmonary diseaseExercise testingControl participantsPeak VOExertional limitationCOVID-19Greater ventilatory inefficiencyPeak cardiac indexSex-matched control participantsCohort of patientsSystemic oxygen extractionDead space ventilationOnly mild symptomsExertional intoleranceCardiac indexPulmonary hemodynamicsAcute infectionVentilatory inefficiencyExercise intolerancePathophysiologic mechanismsMild symptomsHyperventilatory responseOxygen extraction
2020
Fick principle and exercise pulmonary hemodynamic determinants of the six‐minute walk distance in pulmonary hypertension
Joseph P, Oliveira RKF, Eslam RB, Agarwal M, Waxman AB, Systrom DM. Fick principle and exercise pulmonary hemodynamic determinants of the six‐minute walk distance in pulmonary hypertension. Pulmonary Circulation 2020, 10: 1-9. PMID: 32994925, PMCID: PMC7502687, DOI: 10.1177/2045894020957576.Peer-Reviewed Original ResearchSix-minute walk distanceSix-minute walk testWalk distancePulmonary hypertensionOxygen deliveryCardiac reserveWalk testHemodynamic determinantsFick principleMixed venous blood samplesDepressed cardiac indexRight heart afterloadPulmonary vascular resistanceRight heart catheterizationRight ventricular afterloadStroke volume indexTotal pulmonary resistancePulmonary artery catheterPulmonary vascular pressuresSystemic oxygen deliveryVenous blood samplesImpaired oxygen deliveryFick cardiac outputCardiac indexHeart catheterization