2022
Cardiac Complications of Human Babesiosis
Spichler-Moffarah A, Ong E, O’Bryan J, Krause PJ. Cardiac Complications of Human Babesiosis. Clinical Infectious Diseases 2022, 76: e1385-e1391. PMID: 35983604, PMCID: PMC10169432, DOI: 10.1093/cid/ciac525.Peer-Reviewed Original ResearchConceptsYale-New Haven HospitalCardiac complicationsRisk factorsIntensive care unit stayCardiovascular disease risk factorsHuman babesiosisCommon cardiac complicationHigh-grade parasitemiaLife-threatening complicationsDisease risk factorsLonger median lengthQT interval prolongationHigh mortality rateUnit stayComplication groupTick-borne diseaseAdult patientsCardiac outcomesMost patientsThin blood smearsHeart failureInterval prolongationModerate illnessRecord reviewAtrial fibrillation
2021
Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis
Krause PJ, Auwaerter PG, Bannuru RR, Branda JA, Falck-Ytter YT, Lantos PM, Lavergne V, Meissner HC, Osani MC, Rips JG, Sood SK, Vannier E, Vaysbrot EE, Wormser GP. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis. Clinical Infectious Diseases 2021, 72: 185-189. PMID: 33501959, DOI: 10.1093/cid/ciab050.Peer-Reviewed Original ResearchConceptsInfectious Diseases SocietyDiseases SocietyInfectious disease specialistsClinical practice guidelinesPrimary care physiciansTransfusion medicine specialistsEvidence-based guidanceHuman granulocytic anaplasmosisRheumatology guidelinesDisease guidelinesCare physiciansDisease specialistsEmergency physiciansPractice guidelinesAmerican CollegeMedicine specialistsAmerican AcademyDisease controlLyme diseaseGranulocytic anaplasmosisDiagnosisPhysiciansBabesiosisGuidelinesTreatment
2020
Borrelia burgdorferi and Borrelia miyamotoi seroprevalence in California blood donors
Brummitt SI, Kjemtrup AM, Harvey DJ, Petersen JM, Sexton C, Replogle A, Packham AE, Bloch EM, Barbour AG, Krause PJ, Green V, Smith WA. Borrelia burgdorferi and Borrelia miyamotoi seroprevalence in California blood donors. PLOS ONE 2020, 15: e0243950. PMID: 33370341, PMCID: PMC7769429, DOI: 10.1371/journal.pone.0243950.Peer-Reviewed Original ResearchConceptsLyme diseaseBlood donorsB. miyamotoiB. burgdorferiEndemic countiesWestern blotBorrelia miyamotoiB. burgdorferi antibodiesAdult blood donorsBorrelia burgdorferiIgG Western blotBlood donor seraRisk of infectionELISA test systemBurgdorferi antibodiesDonor seraC6 ELISAClinical casesEquivocal samplesHuman casesDiseaseAntibodiesI. pacificus ticksMiyamotoiBurgdorferiClinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner HC, Nigrovic LE, Nocton J, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. Clinical Infectious Diseases 2020, 72: e1-e48. PMID: 33417672, DOI: 10.1093/cid/ciaa1215.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsCommunicable DiseasesHumansLyme DiseaseNeurologyNorth AmericaRheumatologyUnited StatesConceptsInfectious Diseases SocietyClinical practice guidelinesLyme diseaseDiseases SocietyPractice guidelinesAmerican CollegeEvidence-based clinical practice guidelinesAmerican AcademyTick-borne rickettsial infectionInfectious disease specialistsPrimary care physiciansRheumatologic manifestationsCare physiciansErythema migransDisease specialistsMultidisciplinary panelEmergency physiciansFamily physiciansRickettsial infectionTick-borne pathogensDiseaseSeparate guidelinesPhysiciansDiagnosisPreventionClinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner HC, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. Clinical Infectious Diseases 2020, 72: 1-8. PMID: 33483734, DOI: 10.1093/cid/ciab049.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsCommunicable DiseasesHumansLyme DiseaseNeurologyNorth AmericaRheumatologyUnited StatesConceptsInfectious Diseases SocietyClinical practice guidelinesLyme diseaseDiseases SocietyPractice guidelinesAmerican CollegeEvidence-based clinical practice guidelinesAmerican AcademyTick-borne rickettsial infectionInfectious disease specialistsPrimary care physiciansRheumatologic manifestationsCare physiciansErythema migransDisease specialistsMultidisciplinary panelEmergency physiciansFamily physiciansRickettsial infectionTick-borne pathogensDiseaseSeparate guidelinesPhysiciansDiagnosisPreventionClinical Practice Guidelines by the Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology: 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner HC, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology: 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Neurology 2020, 96: 262-273. PMID: 33257476, DOI: 10.1212/wnl.0000000000011151.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInfectious Diseases SocietyClinical practice guidelinesLyme diseaseDiseases SocietyPractice guidelinesAmerican CollegeEvidence-based clinical practice guidelinesAmerican AcademyTick-borne rickettsial infectionInfectious disease specialistsPrimary care physiciansRheumatologic manifestationsCare physiciansErythema migransDisease specialistsMultidisciplinary panelEmergency physiciansFamily physiciansRickettsial infectionTick-borne pathogensDiseaseSeparate guidelinesPhysiciansDiagnosisPreventionClinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis
Krause PJ, Auwaerter PG, Bannuru RR, Branda JA, Falck-Ytter YT, Lantos PM, Lavergne V, Meissner HC, Osani MC, Rips JG, Sood SK, Vannier E, Vaysbrot EE, Wormser GP. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis. Clinical Infectious Diseases 2020, 72: e49-e64. PMID: 33252652, DOI: 10.1093/cid/ciaa1216.Peer-Reviewed Original ResearchConceptsInfectious Diseases SocietyDiseases SocietyInfectious disease specialistsClinical practice guidelinesPrimary care physiciansTransfusion medicine specialistsEvidence-based guidanceHuman granulocytic anaplasmosisRheumatology guidelinesDisease guidelinesCare physiciansDisease specialistsEmergency physiciansPractice guidelinesAmerican CollegeMedicine specialistsAmerican AcademyDisease controlLyme diseaseGranulocytic anaplasmosisDiagnosisPhysiciansBabesiosisGuidelinesTreatmentClinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck‐Ytter Y, Aguero‐Rosenfeld M, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner H, Nigrovic LE, Nocton J, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Arthritis Care & Research 2020, 73: 1-9. PMID: 33251700, DOI: 10.1002/acr.24495.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsClinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner H, Nigrovic LE, Nocton J, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Arthritis & Rheumatology 2020, 73: 12-20. PMID: 33251716, DOI: 10.1002/art.41562.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2015
Coinfection by Ixodes Tick-Borne Pathogens: Ecological, Epidemiological, and Clinical Consequences
Diuk-Wasser MA, Vannier E, Krause PJ. Coinfection by Ixodes Tick-Borne Pathogens: Ecological, Epidemiological, and Clinical Consequences. Trends In Parasitology 2015, 32: 30-42. PMID: 26613664, PMCID: PMC4713283, DOI: 10.1016/j.pt.2015.09.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachnid VectorsBabesia microtiBabesiosisBorrelia burgdorferiCoinfectionHumansIxodesLyme DiseaseConceptsB. microtiDisease severityGreater disease severityEnzootic cycleCoinfected individualsTick-borne pathogenClinical consequencesTherapeutic strategiesLyme diseaseBabesia microtiHost factorsCoinfectionBorrelia burgdorferiB. burgdorferiIxodes ticksMicrotiReservoir hostsSeverityHuman pathogensBurgdorferi
2014
Borrelia miyamotoi sensu lato Seroreactivity and Seroprevalence in the Northeastern United States - Volume 20, Number 7—July 2014 - Emerging Infectious Diseases journal - CDC
Krause PJ, Narasimhan S, Wormser GP, Barbour AG, Platonov AE, Brancato J, Lepore T, Dardick K, Mamula M, Rollend L, Steeves TK, Diuk-Wasser M, Usmani-Brown S, Williamson P, Sarksyan DS, Fikrig E, Fish D, . Borrelia miyamotoi sensu lato Seroreactivity and Seroprevalence in the Northeastern United States - Volume 20, Number 7—July 2014 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2014, 20: 1183-1190. PMID: 24960072, PMCID: PMC4073859, DOI: 10.3201/eid2007.131587.Peer-Reviewed Original ResearchConceptsB. burgdorferiInfectious Diseases journal - CDCSeroprevalence of IgGB. burgdorferi antigensLyme disease endemic areaDisease-endemic areasAntibody testingHealthy personsLyme diseaseSerum samplesSeroprevalenceBurgdorferiInfectionSame tickUnited StatesSensu latoArea residentsPersonsBorrelia spSeroreactivityIgGAntigenDiseaseSerum
2013
Lyme Disease and the Heart
Krause PJ, Bockenstedt LK. Lyme Disease and the Heart. Circulation 2013, 127: e451-e454. PMID: 23429899, DOI: 10.1161/circulationaha.112.101485.Peer-Reviewed Original Research
2011
Long-Term Lyme Disease Antibiotic Therapy Beliefs Among New England Residents
Macauda MM, Erickson P, Miller J, Mann P, Closter L, Krause PJ. Long-Term Lyme Disease Antibiotic Therapy Beliefs Among New England Residents. Vector-Borne And Zoonotic Diseases 2011, 11: 857-862. PMID: 21417921, DOI: 10.1089/vbz.2010.0116.Peer-Reviewed Original ResearchConceptsLyme diseasePersistent symptomsAntibiotic treatmentEffective doctor-patient communicationAntibiotic therapy regimensInfectious Diseases SocietyLong-term treatmentBorrelia burgdorferi infectionDoctor-patient communicationFederal health agenciesDiseases SocietyAppropriate therapyTherapy regimensAntimicrobial therapyBurgdorferi infectionHealthcare workersMost physiciansStandard diagnosisDisease controlDiseasePatientsHealth agenciesSymptomsPhysiciansMedical societies
2007
Serum Reactivity against Borrelia burgdorferi OspA in Patients with Rheumatoid Arthritis▿
Hsieh YF, Liu HW, Hsu TC, Wei J, Shih CM, Krause PJ, Tsay GJ. Serum Reactivity against Borrelia burgdorferi OspA in Patients with Rheumatoid Arthritis▿. MSphere 2007, 14: 1437-1441. PMID: 17881508, PMCID: PMC2168181, DOI: 10.1128/cvi.00151-07.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntibodies, BacterialAntigens, BacterialAntigens, SurfaceArthritis, RheumatoidAutoimmune DiseasesBacterial Outer Membrane ProteinsBacterial VaccinesBlotting, WesternBorrelia burgdorferiEnzyme-Linked Immunosorbent AssayFemaleHumansLipoproteinsLyme DiseaseMaleMiddle AgedRecombinant Fusion ProteinsConceptsRheumatoid arthritis patientsRheumatoid arthritisOspA antigenArthritis patientsAutoimmune diseasesSerum reactivityLyme diseaseDisease Activity ScoreCommon clinical featuresLyme disease patientsSurface protein AArthritis correlatesSynovial histologyOuter surface protein ALyme arthritisActivity scoreClinical featuresDisease patientsSerum concentrationsSimilar pathogenesisHealthy subjectsPatientsArthritisDisease severityDisease
2006
Reinfection and relapse in early Lyme disease.
KRAUSE PJ, FOLEY DT, BURKE GS, Christianson D, Closter L, Spielman A, _ _. Reinfection and relapse in early Lyme disease. American Journal Of Tropical Medicine And Hygiene 2006, 75: 1090-4. PMID: 17172372, DOI: 10.4269/ajtmh.2006.75.1090.Peer-Reviewed Original ResearchConceptsEarly Lyme diseaseRecurrent episodesLyme diseaseErythema migransStandard antibiotic therapyInitial rashPrompt administrationAntibiotic therapyClinical manifestationsPrevent relapsePersistent infectionBody sitesDiseaseSequential episodesSpecific antibodiesEndemic sitesEpisodesReinfectionRelapseDetectable levelsFrequent contactVector ticksYearsRashSerologyThe Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America
Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB. The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America. Clinical Infectious Diseases 2006, 43: 1089-1134. PMID: 17029130, DOI: 10.1086/508667.Peer-Reviewed Original ResearchMeSH KeywordsAnaplasmosisAnimalsBabesiosisEhrlichiosisHealth PersonnelHumansLyme DiseaseSyndromeTick-Borne DiseasesConceptsInfectious Diseases SocietyHuman granulocytic anaplasmosisDiseases SocietyLyme diseasePost-Lyme disease syndromeGranulocytic anaplasmosisPrevious treatment guidelinesManagement of patientsClinical practice guidelinesEvidence-based guidelinesHealth care providersTickborne infectionTreatment guidelinesClinical manifestationsAntimicrobial therapyClinical assessmentPractice guidelinesCare providersDisease syndromeExpert panelDiseasePreventionPatientsTherapyInfection
2005
Hypersensitivity to Ticks and Lyme Disease Risk
Burke G, Wikel SK, Spielman A, Telford SR, McKay K, Krause PJ, . Hypersensitivity to Ticks and Lyme Disease Risk. Emerging Infectious Diseases 2005, 11: 36-41. PMID: 15705320, PMCID: PMC3294369, DOI: 10.3201/eid1101.040303.Peer-Reviewed Original ResearchConceptsTick biteLyme diseaseLyme disease-endemic regionsNymphal Ixodes scapularis ticksLyme disease infectionDisease-endemic regionsCutaneous hypersensitivityIxodes scapularis ticksStudy participantsDisease riskPrior exposureDiseaseBorrelia burgdorferiFrequent exposureScapularis ticksBiteItchLyme disease riskHypersensitivityVector ticksTicksPrevious yearExposureDisease infectionResidents
2002
Disease-Specific Diagnosis of Coinfecting Tickborne Zoonoses: Babesiosis, Human Granulocytic Ehrlichiosis, and Lyme Disease
Krause PJ, McKay K, Thompson CA, Sikand VK, Lentz R, Lepore T, Closter L, Christianson D, Telford SR, Persing D, Radolf JD, Spielman A, Group A. Disease-Specific Diagnosis of Coinfecting Tickborne Zoonoses: Babesiosis, Human Granulocytic Ehrlichiosis, and Lyme Disease. Clinical Infectious Diseases 2002, 34: 1184-1191. PMID: 11941544, DOI: 10.1086/339813.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisLyme diseaseImmunoglobulin M antibody testGranulocytic ehrlichiosisPolymerase chain reaction testingShort-term complicationsComplete blood countDisease-specific diagnosisFlulike illnessThin blood smearsLaboratory manifestationsAcute manifestationsBlood countBlood samplesAntibody testReaction testingBlood smearsTickborne zoonosesDiseaseHuman babesiosisLaboratory test resultsPatientsStructured questionnaireSymptomsBabesiosis
2001
Diagnosis of Babesiosis Using an Immunoblot Serologic Test
Ryan R, Krause P, Radolf J, Freeman K, Spielman A, Lenz R, Levin A. Diagnosis of Babesiosis Using an Immunoblot Serologic Test. MSphere 2001, 8: 1177-1180. PMID: 11687460, PMCID: PMC96246, DOI: 10.1128/cdli.8.6.1177-1180.2001.Peer-Reviewed Original ResearchConceptsB. microti antigenAntibody testHuman babesiosisB. microtiReactivity of seraDiagnostic antibody testsHuman granulocytic ehrlichiosisDiagnosis of babesiosisImmunoblot stripsRoutine clinical diagnosisSerologic testsAcute babesiosisIFA testLaboratory evidenceClinical diagnosisImmunoblot assayGranulocytic ehrlichiosisLyme diseaseAntigenSerumGI strainsInterpretive criteriaReactive bandsTest sensitivityHuman subjectsCoinfecting Deer-Associated Zoonoses: Lyme Disease, Babesiosis, and Ehrlichiosis
Goldstein E, Thompson C, Spielman A, Krause P. Coinfecting Deer-Associated Zoonoses: Lyme Disease, Babesiosis, and Ehrlichiosis. Clinical Infectious Diseases 2001, 33: 676-685. PMID: 11486290, DOI: 10.1086/322681.Peer-Reviewed Original ResearchConceptsLyme diseaseDuration of symptomsHuman granulocytic ehrlichiosisTickborne infectionClinical managementHealth burdenHuman coinfectionsDiagnostic proceduresGranulocytic ehrlichiosisDisease syndromeHuman babesiosisRodent reservoirsHuman hostInfectionDiseaseEhrlichiosisDiversity of pathogensBabesiosisPathogensCoinfectionSyndromeSymptomsIncidenceVector host