2023
Transfusion-transmitted Babesia spp.: a changing landscape of epidemiology, regulation, and risk mitigation
Drews S, Kjemtrup A, Krause P, Lambert G, Leiby D, Lewin A, O'Brien S, Renaud C, Tonnetti L, Bloch E. Transfusion-transmitted Babesia spp.: a changing landscape of epidemiology, regulation, and risk mitigation. Journal Of Clinical Microbiology 2023, 61: e01268-22. PMID: 37750699, PMCID: PMC10595070, DOI: 10.1128/jcm.01268-22.Peer-Reviewed Original ResearchConceptsBlood productsWhole blood-derived platelet concentratesNon-endemic areasNon-endemic regionsTTB casesMost patientsRed blood cellsClinical presentationSevere illnessBlood donorsDead-end hostsTick-borne parasitesHuman transmissionEndemic regionsClinical settingEpidemiologyBlood cellsCase numbersPlatelet concentratesTransfusionRisk
2021
Babesia microti: Pathogen Genomics, Genetic Variability, Immunodominant Antigens, and Pathogenesis
Puri A, Bajpai S, Meredith S, Aravind L, Krause PJ, Kumar S. Babesia microti: Pathogen Genomics, Genetic Variability, Immunodominant Antigens, and Pathogenesis. Frontiers In Microbiology 2021, 12: 697669. PMID: 34539601, PMCID: PMC8446681, DOI: 10.3389/fmicb.2021.697669.Peer-Reviewed Original ResearchPolymerase chain reactionPerinatal transmissionBlood transfusionModerate diseaseMost infectionsOrgan transplantationImmune evasionBlood smearsImmunodominant antigensHuman babesiosisInfection severityPathogenesisChain reactionPotential roleCell surface proteinsDiseaseDiagnosisHuman diseasesPathogen genomicsBabesiosisIxodid ticksPhylum ApicomplexaTransfusionTransplantationHumans
2019
Repeat exchange transfusion for treatment of severe babesiosis
Radcliffe C, Krause PJ, Grant M. Repeat exchange transfusion for treatment of severe babesiosis. Transfusion And Apheresis Science 2019, 58: 638-640. PMID: 31526674, DOI: 10.1016/j.transci.2019.07.010.Peer-Reviewed Case Reports and Technical NotesConceptsRepeat exchange transfusionExchange transfusionSevere babesiosisHospital day 5Second exchange transfusionBabesia microti infectionHigh feverRheumatoid arthritisMicroti infectionTransfusionDay 5Literature searchDearth of informationParasitemiaInfectionBabesiosisEtanerceptArthritisFeverClindamycinHypoxiaCasesWeeksWomenHuman babesiosis
Krause PJ. Human babesiosis. International Journal For Parasitology 2019, 49: 165-174. PMID: 30690090, DOI: 10.1016/j.ijpara.2018.11.007.Peer-Reviewed Original ResearchConceptsBurden of infectionSignificant health burdenNon-endemic areasTick-borne diseaseThin blood smearsBlood transfusionExchange transfusionHealth burdenSevere casesBlood smearsHuman babesiosisIntraerythrocytic parasitesTransfusionInfectionBabesiosisBurdenProtective measuresBabesia DNAClindamycinAzithromycinAtovaquoneDiseaseSmearsDiagnosis
2015
Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both?
Saifee NH, Krause PJ, Wu Y. Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both? Journal Of Clinical Apheresis 2015, 31: 454-458. PMID: 26481763, DOI: 10.1002/jca.21429.Peer-Reviewed Original ResearchConceptsExchange transfusionHigh-risk populationLife-threatening illnessApparent therapeutic benefitBlood transfusionModerate diseaseClinical presentationAsymptomatic infectionSevere babesiosisSevere diseaseRisk populationsTherapeutic benefitTransfusionMortality rateIntraerythrocytic protozoan parasiteBabesia infectionDiseaseIxodes ticksProtozoan parasiteBabesiosisInfectionGenus BabesiaMost casesPatientsClindamycinBabesiosis
Vannier EG, Diuk-Wasser MA, Mamoun C, Krause PJ. Babesiosis. Infectious Disease Clinics Of North America 2015, 29: 357-370. PMID: 25999229, PMCID: PMC4458703, DOI: 10.1016/j.idc.2015.02.008.Peer-Reviewed Original Research
2014
Blood transfusion transmission of the tick‐borne relapsing fever spirochete Borrelia miyamotoi in mice
Krause PJ, Hendrickson JE, Steeves TK, Fish D. Blood transfusion transmission of the tick‐borne relapsing fever spirochete Borrelia miyamotoi in mice. Transfusion 2014, 55: 593-597. PMID: 25251880, DOI: 10.1111/trf.12879.Peer-Reviewed Original ResearchConceptsTransfusion transmissionRed blood cellsBorrelia miyamotoiBlood transfusion transmissionMurine transfusion modelFever spirochete Borrelia miyamotoiSpirochete clearanceRecipient bloodC57BL/6 miceMouse recipientsTransfusion modelMouse modelTransfusionMurine bloodHuman infectionsWet mountLyme diseaseStudy designBlood cellsMiceMiyamotoiSpirochetemiaFever spirochetesBloodBodied ticks
2013
Chapter 14 Neurological manifestations of human babesiosis
Usmani-Brown S, Halperin JJ, Krause PJ. Chapter 14 Neurological manifestations of human babesiosis. Handbook Of Clinical Neurology 2013, 114: 199-203. PMID: 23829910, DOI: 10.1016/b978-0-444-53490-3.00014-5.Peer-Reviewed Original ResearchConceptsLevel of consciousnessRare complicationBlood transfusionNeurological manifestationsCommon symptomsNeurological dysfunctionFatal diseaseInfectious diseasesIntraerythrocytic protozoaHuman babesiosisDiseaseBabesiosisIxodid ticksTransfusionComplicationsHeadacheDysfunctionLethargyPathogenesisSymptoms
2008
Human Babesiosis
Vannier E, Gewurz BE, Krause PJ. Human Babesiosis. Infectious Disease Clinics Of North America 2008, 22: 469-488. PMID: 18755385, PMCID: PMC3998201, DOI: 10.1016/j.idc.2008.03.010.Peer-Reviewed Original ResearchConceptsBabesial infectionHuman babesiosisCombination of atovaquoneTreatment of choiceSpecific laboratory diagnosisModerate illnessExchange transfusionPolymerase chain reactionSevere diseaseLaboratory diagnosisMorphologic examinationBlood smearsProtozoal parasitesInfectionChain reactionBabesial DNABabesiosisIntraerythrocytic infectionUnited StatesIxodid ticksTransfusionUpper midwestern regionsClindamycinSerologyAzithromycin
1989
Enhancement of neutrophil function for treatment of neonatal infections
KRAUSE P, HERSON V, EISENFELD L, JOHNSON G. Enhancement of neutrophil function for treatment of neonatal infections. The Pediatric Infectious Disease Journal 1989, 8: 382-389. PMID: 2664694, DOI: 10.1097/00006454-198906000-00011.Peer-Reviewed Original ResearchConceptsNewborn infantsRisk of morbidityFresh frozen plasmaMaximum therapeutic benefitHost defense mechanismsNeonatal infectionImportant therapyNeutrophil functionFrozen plasmaPMN functionTherapeutic benefitAdult PMNInfectionFurther studiesInfantsNew antibioticsDefense mechanismsTransfusionMorbidityNeonatesTherapyMortalityAdministrationImpairmentAntibodies