2024
Tafenoquine for Relapsing Babesiosis: A Case Series
Krause P, Rogers R, Shah M, Kang H, Parsonnet J, Kodama R, Vannier E. Tafenoquine for Relapsing Babesiosis: A Case Series. Clinical Infectious Diseases 2024, 79: 130-137. PMID: 38814096, PMCID: PMC11259219, DOI: 10.1093/cid/ciae238.Peer-Reviewed Original ResearchRelapsing babesiosisPolymerase chain reactionReal-time polymerase chain reactionImmunocompromised patientsTreatment of Plasmodium vivax malariaPlasmodium vivax malariaModel of acute infectionAntimicrobial agentsBlood smearsAnimal models of acute infectionsWeekly maintenance dosesAcquisition of resistanceAtovaquone-proguanilVivax malariaMalaria prophylaxisMaintenance doseLoading doseCase seriesDelayed clearanceAcute infectionTafenoquinePrevent relapseThin blood smearsLow dosesAnimal models
2021
Babesia microti: Pathogen Genomics, Genetic Variability, Immunodominant Antigens, and Pathogenesis
Puri A, Bajpai S, Meredith S, Aravind L, Krause PJ, Kumar S. Babesia microti: Pathogen Genomics, Genetic Variability, Immunodominant Antigens, and Pathogenesis. Frontiers In Microbiology 2021, 12: 697669. PMID: 34539601, PMCID: PMC8446681, DOI: 10.3389/fmicb.2021.697669.Peer-Reviewed Original ResearchPolymerase chain reactionPerinatal transmissionBlood transfusionModerate diseaseMost infectionsOrgan transplantationImmune evasionBlood smearsImmunodominant antigensHuman babesiosisInfection severityPathogenesisChain reactionPotential roleCell surface proteinsDiseaseDiagnosisHuman diseasesPathogen genomicsBabesiosisIxodid ticksPhylum ApicomplexaTransfusionTransplantationHumans
2020
Clofazimine, a Promising Drug for the Treatment of Babesia microti Infection in Severely Immunocompromised Hosts
Tuvshintulga B, Vannier E, Tayebwa DS, Gantuya S, Sivakumar T, Guswanto A, Krause PJ, Yokoyama N, Igarashi I. Clofazimine, a Promising Drug for the Treatment of Babesia microti Infection in Severely Immunocompromised Hosts. The Journal Of Infectious Diseases 2020, 222: 1027-1036. PMID: 32310272, DOI: 10.1093/infdis/jiaa195.Peer-Reviewed Original ResearchConceptsB. microti parasitesMicroti infectionHigh-grade parasitemiaDrug-resistant tuberculosisB. microtiBabesia microti infectionAdditional preclinical studiesB. microti infectionImmunocompromised hostB. microti DNAPolymerase chain reactionPreclinical studiesIncidence of babesiosisPromising drugRadical cureMinimal doseClofazimineDay 10Blood smearsBabesia microtiNovel drugsParasitemiaChain reactionMicroscopic examinationAntimicrobial agents105 Babesiosis
Vannier E, Krause P. 105 Babesiosis. 2020, 799-802. DOI: 10.1016/b978-0-323-55512-8.00105-8.Peer-Reviewed Original ResearchPolymerase chain reactionProphylactic antibiotic regimenLife-threatening complicationsMainstay of treatmentSolid organ transplantationBest preventive measureAntibiotic regimenFrequent symptomsHospital admissionDefinitive diagnosisSevere babesiosisBlood productsOrgan transplantationEtiologic agentBabesia microtiPreventive measuresZoonotic diseaseChain reactionB. duncaniBabesiosisDiseaseB. venatorumHemoprotozoan parasitesB. divergensAlternative option
2018
Superior real‐time polymerase chain reaction detection of Babesia microti parasites in whole blood utilizing high‐copy BMN antigens as amplification targets
Grabias B, Clement J, Krause PJ, Lepore T, Kumar S. Superior real‐time polymerase chain reaction detection of Babesia microti parasites in whole blood utilizing high‐copy BMN antigens as amplification targets. Transfusion 2018, 58: 1924-1932. PMID: 29664114, DOI: 10.1111/trf.14642.Peer-Reviewed Original ResearchConceptsParasites/mLBlood donorsBlood samplesSeroreactive antigensBabesia microti parasitesWhole bloodTransfusion-transmitted infectionsParasite nucleic acidsReal-time polymerase chain reactionWhole blood samplesPolymerase chain reaction detectionPolymerase chain reactionSensitive molecular assaysBlood productsClinical characterizationRT-PCR detectionReal-time polymerase chain reaction detectionLaboratory diagnosisBabesia microtiStudy designInfected ticksDilution panelsAntigenZoonotic diseaseBloodHuman Babesiosis Caused by a Babesia crassa–Like Pathogen: A Case Series
Jia N, Zheng YC, Jiang JF, Jiang RR, Jiang BG, Wei R, Liu HB, Huo QB, Sun Y, Chu YL, Fan H, Chang QC, Yao NN, Zhang WH, Wang H, Guo DH, Fu X, Wang YW, Krause PJ, Song JL, Cao WC. Human Babesiosis Caused by a Babesia crassa–Like Pathogen: A Case Series. Clinical Infectious Diseases 2018, 67: 1110-1119. PMID: 29538646, DOI: 10.1093/cid/ciy212.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionAsymptomatic infectionTick biteHuman babesiosisInfection 9 monthsRecent tick biteViral-like illnessCommon clinical manifestationsHaemaphysalis concinna ticksCase seriesInitial diagnosisClinical manifestationsOvarian tumorsModerate symptomsUS CentersBlood supplySevere diseaseHealthy residentsHealth problemsDisease controlInfectionChain reactionGenetic sequencingPatientsFurther investigation
2016
Hard Tick Relapsing Fever Caused by Borrelia miyamotoi in a Child
Krause P, Schwab J, Narasimhan S, Brancato J, Xu G, Rich SM. Hard Tick Relapsing Fever Caused by Borrelia miyamotoi in a Child. The Pediatric Infectious Disease Journal 2016, 35: 1352-1354. PMID: 27626914, PMCID: PMC5106309, DOI: 10.1097/inf.0000000000001330.Peer-Reviewed Original Research
2012
Preventing transfusion‐transmitted babesiosis: preliminary experience of the first laboratory‐based blood donor screening program
Young C, Chawla A, Berardi V, Padbury J, Skowron G, Krause PJ, Group T. Preventing transfusion‐transmitted babesiosis: preliminary experience of the first laboratory‐based blood donor screening program. Transfusion 2012, 52: 1523-1529. PMID: 22452654, DOI: 10.1111/j.1537-2995.2012.03612.x.Peer-Reviewed Original ResearchConceptsTransfusion-transmitted babesiosisCases of TTBPolymerase chain reactionBlood donorsThalassemia patientsCommon transfusion-transmitted infectionSickle cellsIndeterminate PCR resultsPositive IFA resultsTransfusion-transmitted infectionsInvestigational new drug applicationReal-time polymerase chain reactionUnscreened bloodDonor screeningPatientsIFA resultsDrug AdministrationNew drug applicationsPreliminary experienceIndirect immunofluorescenceBabesia microtiStudy designDrug applicationChain reactionPCR results
2008
Human Babesiosis
Vannier E, Gewurz BE, Krause PJ. Human Babesiosis. Infectious Disease Clinics Of North America 2008, 22: 469-488. PMID: 18755385, PMCID: PMC3998201, DOI: 10.1016/j.idc.2008.03.010.Peer-Reviewed Original ResearchConceptsBabesial infectionHuman babesiosisCombination of atovaquoneTreatment of choiceSpecific laboratory diagnosisModerate illnessExchange transfusionPolymerase chain reactionSevere diseaseLaboratory diagnosisMorphologic examinationBlood smearsProtozoal parasitesInfectionChain reactionBabesial DNABabesiosisIntraerythrocytic infectionUnited StatesIxodid ticksTransfusionUpper midwestern regionsClindamycinSerologyAzithromycin
2007
ATOVAQUONE AND AZITHROMYCIN TREATMENT FOR BABESIOSIS IN AN INFANT
Raju M, Salazar JC, Leopold H, Krause PJ. ATOVAQUONE AND AZITHROMYCIN TREATMENT FOR BABESIOSIS IN AN INFANT. The Pediatric Infectious Disease Journal 2007, 26: 181-183. PMID: 17259886, DOI: 10.1097/01.inf.0000250622.11505.8f.Peer-Reviewed Original ResearchConceptsCyanotic heart diseaseBabesia microti infectionTreatment of childrenOral azithromycinThin blood smearsInitial presentationSevere anemiaHeart diseaseMicroti infectionPolymerase chain reactionHepatic enzymesBlood smearsInfantsIntraerythrocytic parasitesChain reactionTreatmentBabesiosisLaboratory testsFebrileThrombocytopeniaCyanoticAnemiaClindamycinSerologyAzithromycin
2003
Babesiosis Diagnosis and Treatment
Krause PJ. Babesiosis Diagnosis and Treatment. Vector-Borne And Zoonotic Diseases 2003, 3: 45-51. PMID: 12804380, DOI: 10.1089/153036603765627451.Peer-Reviewed Original ResearchConceptsBlood smearsThin blood smearsPolymerase chain reactionRobust antibody responseLife-saving therapyUseful screening testPulmonary compromiseSubclinical illnessSerologic testingClinical manifestationsExchange transfusionAntibody responseAdverse reactionsHigh parasitemiaConclusive diagnosisSevere diseaseAccurate diagnosisScreening testBabesial infectionBabesia microtiHuman babesiosisInfectionSignificant hemolysisDiseaseSmears
2002
Babesiosis
Krause PJ. Babesiosis. Medical Clinics Of North America 2002, 86: 361-373. PMID: 11982307, DOI: 10.1016/s0025-7125(03)00092-0.Peer-Reviewed Original ResearchConceptsAge 50 yearsFlulike illnessThin blood smearsHIV infectionHospital admissionExchange transfusionAsplenic individualsImmunosuppressive drugsPolymerase chain reactionSevere casesSpecific diagnosisFatal diseaseBlood smearsProtozoal parasitesGreater riskLyme diseaseSpecific antibodiesChain reactionTransmits Lyme diseaseInfectionDiseaseBabesiosisSame tickNorthern midwestern United StatesMost cases
1995
Infection with a Babesia-Like Organism in Northern California
Persing D, Herwaldt B, Glaser C, Lane R, Thomford J, Mathiesen D, Krause P, Phillip D, Conrad P. Infection with a Babesia-Like Organism in Northern California. New England Journal Of Medicine 1995, 332: 298-303. PMID: 7816065, DOI: 10.1056/nejm199502023320504.Peer-Reviewed Original ResearchConceptsB. microti antigenIndirect immunofluorescent antibody testingImmunofluorescent antibody testingInfluenza-like illnessHodgkin's diseaseSerologic testingAsymptomatic infectionClinical spectrumSeroprevalence ratesPolymerase chain reactionPatientsFatal diseaseProtozoal parasitesInfectionBabesia microtiHuman babesiosisBabesia antigensDiseaseGenetic sequence analysisChain reactionCanine pathogensAntigenB. divergensGenus Babesia