2022
Animal models of the immunology and pathogenesis of human babesiosis
Kumar A, Kabra A, Igarashi I, Krause P. Animal models of the immunology and pathogenesis of human babesiosis. Trends In Parasitology 2022, 39: 38-52. PMID: 36470781, DOI: 10.1016/j.pt.2022.11.003.Peer-Reviewed Original ResearchConceptsAnimal modelsHuman babesiosisBabesia infectionImmunological mechanismsModerate diseaseOrgan dysfunctionPathologic responseDisease complicationsAsymptomatic infectionSevere diseaseAnimal studiesInfectionPathological processesDiseaseBabesiosisBabesia speciesAnimalsDomestic animalsComplicationsDysfunctionPathogenesisImmunology
2021
Babesia microti: Pathogen Genomics, Genetic Variability, Immunodominant Antigens, and Pathogenesis
Puri A, Bajpai S, Meredith S, Aravind L, Krause PJ, Kumar S. Babesia microti: Pathogen Genomics, Genetic Variability, Immunodominant Antigens, and Pathogenesis. Frontiers In Microbiology 2021, 12: 697669. PMID: 34539601, PMCID: PMC8446681, DOI: 10.3389/fmicb.2021.697669.Peer-Reviewed Original ResearchPolymerase chain reactionPerinatal transmissionBlood transfusionModerate diseaseMost infectionsOrgan transplantationImmune evasionBlood smearsImmunodominant antigensHuman babesiosisInfection severityPathogenesisChain reactionPotential roleCell surface proteinsDiseaseDiagnosisHuman diseasesPathogen genomicsBabesiosisIxodid ticksPhylum ApicomplexaTransfusionTransplantationHumans
2013
Chapter 14 Neurological manifestations of human babesiosis
Usmani-Brown S, Halperin JJ, Krause PJ. Chapter 14 Neurological manifestations of human babesiosis. Handbook Of Clinical Neurology 2013, 114: 199-203. PMID: 23829910, DOI: 10.1016/b978-0-444-53490-3.00014-5.Peer-Reviewed Original ResearchConceptsLevel of consciousnessRare complicationBlood transfusionNeurological manifestationsCommon symptomsNeurological dysfunctionFatal diseaseInfectious diseasesIntraerythrocytic protozoaHuman babesiosisDiseaseBabesiosisIxodid ticksTransfusionComplicationsHeadacheDysfunctionLethargyPathogenesisSymptoms
2007
Shared features in the pathobiology of babesiosis and malaria
Krause PJ, Daily J, Telford SR, Vannier E, Lantos P, Spielman A. Shared features in the pathobiology of babesiosis and malaria. Trends In Parasitology 2007, 23: 605-610. PMID: 17988944, DOI: 10.1016/j.pt.2007.09.005.Peer-Reviewed Original ResearchConceptsPlasmodium falciparum infectionPathogenesis of babesiosisFulminant diseaseClinical courseFalciparum infectionSimilar pathogenesisCytokine activationHealth problemsIntraerythrocytic protozoaMalariaPathobiologyContinued investigationPathogenesisBabesiosisDiseaseRecent studiesHumansInfectionImportant diseaseCytoadherence
2006
Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient
Clark IA, Budd AC, Hsue G, Haymore BR, Joyce AJ, Thorner R, Krause PJ. Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient. Malaria Journal 2006, 5: 69. PMID: 16887045, PMCID: PMC1552079, DOI: 10.1186/1475-2875-5-69.Peer-Reviewed Original ResearchConceptsMulti-organ failureParasitized erythrocytesSevere multi-organ failureBabesia microti infectionChronic lymphocytic leukemiaCases of babesiosisFalciparum malariaSplenectomized patientsSimilar pathogenesisVascular occlusionMicroti infectionErythrocyte sequestrationLymphocytic leukemiaProtozoal infectionsVascular locationColon cancerHuman patientsResultsNo evidenceVascular lumenHuman casesB. microtiTissue sectionsPatientsPathogenesisInfection
1984
Occurrence of Clostridium difficile toxin-associated gastroenteritis following antibiotic therapy for otitis media in young children
HYAMS J, FEDER H, KRAUSE P, FRICK J, MCLAUGHLIN J, FURTH T, HINE P. Occurrence of Clostridium difficile toxin-associated gastroenteritis following antibiotic therapy for otitis media in young children. The Pediatric Infectious Disease Journal 1984, 3: 433-436. PMID: 6333674, DOI: 10.1097/00006454-198409000-00009.Peer-Reviewed Original ResearchConceptsToxin-positive stoolsOtitis mediaAntibiotic therapyAcute otitis mediaPathogenesis of diarrheaIncidence of diarrheaYoung childrenClostridium difficile toxinProspective studyDifficile toxinDiarrheaC. difficileOlder childrenFurther studiesPatientsStoolTherapyChildrenAge sixAge threeOutpatientsPathogenesisYearsGastroenteritisIncidence