2022
Comparing the Epidemiology and Health Burden of Lyme Disease and Babesiosis Hospitalizations in the United States
Bloch E, Zhu X, Krause P, Patel E, Grabowski M, Goel R, Auwaerter P, Tobian A. Comparing the Epidemiology and Health Burden of Lyme Disease and Babesiosis Hospitalizations in the United States. Open Forum Infectious Diseases 2022, 9: ofac597. PMID: 36467296, PMCID: PMC9709699, DOI: 10.1093/ofid/ofac597.Peer-Reviewed Original ResearchNational Inpatient SampleLyme diseaseMale patientsAnnual incidenceHealth burdenLonger hospital stayMean hospital chargesHigher inpatient costsHospital-level variablesStratified systematic random sampleUS Census Bureau dataPerson/yearHospital stayPatient demographicsHospital admissionClinical outcomesHospital chargesInpatient costsInpatient hospitalizationInpatient SampleAdmission costsHospitalizationUS hospitalsDisease severitySystematic random sample
2021
The Global Emergence of Human Babesiosis
Kumar A, O’Bryan J, Krause PJ. The Global Emergence of Human Babesiosis. Pathogens 2021, 10: 1447. PMID: 34832603, PMCID: PMC8623124, DOI: 10.3390/pathogens10111447.Peer-Reviewed Original ResearchHuman babesiosisPrimary clinical characteristicsEndemic diseaseGlobal health burdenHard-bodied ticksMode of transmissionFulminant casesTick-borne diseaseClinical characteristicsBlood transfusionDisease locationHealth burdenOrgan transplantationEpidemiologic toolIntraerythrocytic protozoaDiseaseBabesiosisInfectionLike agentsGlobal emergenceHuman pathogensUnited StatesBabesiaWide spectrumPredominant species
2019
Persistence of Babesia microti Infection in Humans
Bloch EM, Kumar S, Krause PJ. Persistence of Babesia microti Infection in Humans. Pathogens 2019, 8: 102. PMID: 31319461, PMCID: PMC6789900, DOI: 10.3390/pathogens8030102.Peer-Reviewed Original ResearchTransfusion-transmitted babesiosisBabesia microti infectionBlood donor screeningImmune evasive strategiesPeripheral blood smearFifth of casesHost immune mechanismsNovel therapeutic measuresNovel preventive approachesHIV/AIDSTick-borne diseaseRed blood cellsSevere complicationsAnti-parasitic drugsBlood transfusionImmunocompetent individualsImmunosuppressive drugsDonor screeningMicroti infectionImmune mechanismsBlood donorsHealth burdenImmunoglobulin preparationsNew anti-parasitic drugsTherapeutic measuresHuman babesiosis
Krause PJ. Human babesiosis. International Journal For Parasitology 2019, 49: 165-174. PMID: 30690090, DOI: 10.1016/j.ijpara.2018.11.007.Peer-Reviewed Original ResearchConceptsBurden of infectionSignificant health burdenNon-endemic areasTick-borne diseaseThin blood smearsBlood transfusionExchange transfusionHealth burdenSevere casesBlood smearsHuman babesiosisIntraerythrocytic parasitesTransfusionInfectionBabesiosisBurdenProtective measuresBabesia DNAClindamycinAzithromycinAtovaquoneDiseaseSmearsDiagnosis
2016
Transfusion-transmitted babesiosis
Levin AE, Krause PJ. Transfusion-transmitted babesiosis. Current Opinion In Hematology 2016, 23: 573-580. PMID: 27537475, PMCID: PMC5241272, DOI: 10.1097/moh.0000000000000287.Peer-Reviewed Original ResearchConceptsTransfusion-transmitted babesiosisBlood donorsB. microti antibodiesInfectious blood donorsAssociated mortality rateOptimal screening strategyTransfusion-transmitted pathogensSignificant health burdenAvailable screening toolsUnited States populationPathogen inactivation methodsMicroti antibodiesSevere illnessHealth burdenMortality rateUS FoodDrug AdministrationBabesia microtiScreening toolLaboratory screeningScreening strategyBabesiosisInactivation methodPCR assaysRecent studies
2003
Increasing health burden of human babesiosis in endemic sites.
KRAUSE PJ, McKay K, Gadbaw J, Christianson D, Closter L, Lepore T, TELFORD SR, Sikand V, Ryan R, Persing D, RADOLF JD, Spielman A, _ _. Increasing health burden of human babesiosis in endemic sites. American Journal Of Tropical Medicine And Hygiene 2003, 68: 431-6. PMID: 12875292, DOI: 10.4269/ajtmh.2003.68.431.Peer-Reviewed Original ResearchConceptsYears of ageEndemic sitesCommunity-based serosurveysClinical spectrumHealth burdenPeople 20Borrelial infectionHuman infectionsBabesial infectionMore older adultsBabesia microtiBabesial antigensOlder adultsHuman babesiosisYoung adultsInfectionBorrelia burgdorferiIncidenceThree-fourthsAdultsAgePrudence IslandSeroprevalenceSerosurveyHospital
2001
Coinfecting Deer-Associated Zoonoses: Lyme Disease, Babesiosis, and Ehrlichiosis
Goldstein E, Thompson C, Spielman A, Krause P. Coinfecting Deer-Associated Zoonoses: Lyme Disease, Babesiosis, and Ehrlichiosis. Clinical Infectious Diseases 2001, 33: 676-685. PMID: 11486290, DOI: 10.1086/322681.Peer-Reviewed Original ResearchConceptsLyme diseaseDuration of symptomsHuman granulocytic ehrlichiosisTickborne infectionClinical managementHealth burdenHuman coinfectionsDiagnostic proceduresGranulocytic ehrlichiosisDisease syndromeHuman babesiosisRodent reservoirsHuman hostInfectionDiseaseEhrlichiosisDiversity of pathogensBabesiosisPathogensCoinfectionSyndromeSymptomsIncidenceVector host