2024
Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG)
Kostka J, Maharjan A, Kumar S, Hackenyos D, Krause P, Dieckhaus K. Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG). PLOS Neglected Tropical Diseases 2024, 18: e0012035. PMID: 38484010, PMCID: PMC10965045, DOI: 10.1371/journal.pntd.0012035.Peer-Reviewed Original ResearchConceptsIntravenous immunoglobulinB. microti antibodiesBabesiosis patientsSpectrum of disease severityCommercial intravenous immunoglobulinEffective treatment strategiesSevere organ damageHost antibody responseImmunocompromised patientsAdjunctive therapyOrgan damageTreatment strategiesAcute andClinical trialsMicroti antibodiesAsymptomatic infectionAntibody responseTherapeutic benefitTherapeutic effectPatientsDisease severityAntibodiesImmunofluorescence assayProtozoan infectionsCommercial samples
2022
Animal models of the immunology and pathogenesis of human babesiosis
Kumar A, Kabra A, Igarashi I, Krause P. Animal models of the immunology and pathogenesis of human babesiosis. Trends In Parasitology 2022, 39: 38-52. PMID: 36470781, DOI: 10.1016/j.pt.2022.11.003.Peer-Reviewed Original ResearchConceptsAnimal modelsHuman babesiosisBabesia infectionImmunological mechanismsModerate diseaseOrgan dysfunctionPathologic responseDisease complicationsAsymptomatic infectionSevere diseaseAnimal studiesInfectionPathological processesDiseaseBabesiosisBabesia speciesAnimalsDomestic animalsComplicationsDysfunctionPathogenesisImmunology
2018
BmGPAC, an Antigen Capture Assay for Detection of Active Babesia microti Infection
Thekkiniath J, Mootien S, Lawres L, Perrin BA, Gewirtz M, Krause PJ, Williams S, Doggett J, Ledizet M, Mamoun C. BmGPAC, an Antigen Capture Assay for Detection of Active Babesia microti Infection. Journal Of Clinical Microbiology 2018, 56: 10.1128/jcm.00067-18. PMID: 30093394, PMCID: PMC6156295, DOI: 10.1128/jcm.00067-18.Peer-Reviewed Original ResearchConceptsHuman babesiosisBabesia microti infectionCapture enzyme-linked immunosorbent assayAntigen capture enzyme-linked immunosorbent assayAntigen capture assayEnzyme-linked immunosorbent assayZoonotic infectious diseaseAcute infectionBlood transfusionAsymptomatic infectionMicroti infectionReal-time PCRBlood supplyAnimal reservoir hostsDonor bloodEpidemiological surveyHuman patientsImmune systemSerological assaysImmunodominant antigensInfectionInfectious diseasesIntraerythrocytic protozoan parasitePatientsImmunosorbent assayHuman Babesiosis Caused by a Babesia crassa–Like Pathogen: A Case Series
Jia N, Zheng YC, Jiang JF, Jiang RR, Jiang BG, Wei R, Liu HB, Huo QB, Sun Y, Chu YL, Fan H, Chang QC, Yao NN, Zhang WH, Wang H, Guo DH, Fu X, Wang YW, Krause PJ, Song JL, Cao WC. Human Babesiosis Caused by a Babesia crassa–Like Pathogen: A Case Series. Clinical Infectious Diseases 2018, 67: 1110-1119. PMID: 29538646, DOI: 10.1093/cid/ciy212.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionAsymptomatic infectionTick biteHuman babesiosisInfection 9 monthsRecent tick biteViral-like illnessCommon clinical manifestationsHaemaphysalis concinna ticksCase seriesInitial diagnosisClinical manifestationsOvarian tumorsModerate symptomsUS CentersBlood supplySevere diseaseHealthy residentsHealth problemsDisease controlInfectionChain reactionGenetic sequencingPatientsFurther investigation
2015
Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both?
Saifee NH, Krause PJ, Wu Y. Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both? Journal Of Clinical Apheresis 2015, 31: 454-458. PMID: 26481763, DOI: 10.1002/jca.21429.Peer-Reviewed Original ResearchConceptsExchange transfusionHigh-risk populationLife-threatening illnessApparent therapeutic benefitBlood transfusionModerate diseaseClinical presentationAsymptomatic infectionSevere babesiosisSevere diseaseRisk populationsTherapeutic benefitTransfusionMortality rateIntraerythrocytic protozoan parasiteBabesia infectionDiseaseIxodes ticksProtozoan parasiteBabesiosisInfectionGenus BabesiaMost casesPatientsClindamycin
2009
Update on Babesiosis
Vannier E, Krause PJ. Update on Babesiosis. Interdisciplinary Perspectives On Infectious Diseases 2009, 2009: 984568. PMID: 19727410, PMCID: PMC2734943, DOI: 10.1155/2009/984568.Peer-Reviewed Original ResearchTick-borne infectious diseaseHuman babesiosisBlood safety riskSpecific antimicrobial therapyMultiple prevention strategiesFulminant diseaseThin blood smearsClinical featuresExchange transfusionModerate illnessImmunosuppressive drugsAsymptomatic infectionDefinitive diagnosisAsymptomatic carriersAntimicrobial therapyConvalescent seraSevere diseaseImmunocompromised individualsHigh riskSevere casesEndemic areasPrevention strategiesBabesia antibodiesHealthy adultsInfection range
2000
Babesiosis
Krause P. Babesiosis. Seminars In Pediatric Infectious Diseases 2000, 11: 182-188. DOI: 10.1053/pi.2000.6229.Peer-Reviewed Original ResearchCombination of clindamycinHuman immunodeficiency virusTypical clinical symptomsPeripheral blood smearDefinitive laboratory diagnosisClinical symptomsImmunodeficiency virusAsymptomatic infectionClinical spectrumSerological evaluationCurrent treatmentSevere diseaseLaboratory diagnosisSporadic casesBlood smearsIntraerythrocytic protozoaLyme diseaseDiseaseEndemic diseaseZoonotic diseaseCausative agentSerious episodesIxodes ticksBabesiosisAdults
1995
Infection with a Babesia-Like Organism in Northern California
Persing D, Herwaldt B, Glaser C, Lane R, Thomford J, Mathiesen D, Krause P, Phillip D, Conrad P. Infection with a Babesia-Like Organism in Northern California. New England Journal Of Medicine 1995, 332: 298-303. PMID: 7816065, DOI: 10.1056/nejm199502023320504.Peer-Reviewed Original ResearchConceptsB. microti antigenIndirect immunofluorescent antibody testingImmunofluorescent antibody testingInfluenza-like illnessHodgkin's diseaseSerologic testingAsymptomatic infectionClinical spectrumSeroprevalence ratesPolymerase chain reactionPatientsFatal diseaseProtozoal parasitesInfectionBabesia microtiHuman babesiosisBabesia antigensDiseaseGenetic sequence analysisChain reactionCanine pathogensAntigenB. divergensGenus Babesia