2016
MRI-US fusion targeted biopsy results in patients with a history of a prior negative biopsy.
Nawaf C, Lu A, Rosoff J, Weinreb J, Schulam P, Humphrey P, Levi A, Sprenkle P. MRI-US fusion targeted biopsy results in patients with a history of a prior negative biopsy. Journal Of Clinical Oncology 2016, 34: 90-90. DOI: 10.1200/jco.2016.34.2_suppl.90.Peer-Reviewed Original ResearchPrior negative biopsyCS cancerGleason scoreNegative MRIProstate cancerNegative biopsyCS prostate cancerMRI suspicion scoreMRI-US fusionPre-biopsy mpMRIFusion prostate biopsyMRI-ultrasound fusionSignificant prostate cancerCancer detection rateBiopsy of lesionsMaximum Gleason scoreMulti-parametric MRIElevated PSAPrevious biopsyRepeat biopsyMapping biopsyBiopsy resultsProstate biopsyFusion biopsyStandard biopsy
2001
Interobserver reproducibility of Gleason grading of prostatic carcinoma: Urologic pathologists
Allsbrook W, Mangold K, Johnson M, Lane R, Lane C, Amin M, Bostwick D, Humphrey P, Jones E, Reuter V, Sakr W, Sesterhenn I, Troncoso P, Wheeler T, Epstein J. Interobserver reproducibility of Gleason grading of prostatic carcinoma: Urologic pathologists. Human Pathology 2001, 32: 74-80. PMID: 11172298, DOI: 10.1053/hupa.2001.21134.Peer-Reviewed Original ResearchConceptsUrologic pathologistsProstatic carcinomaInterobserver reproducibilityGleason scoreGleason gradingGleason grade groupLow-grade tumorsCribriform proliferationNeedle biopsyGroup 2Gleason patternGrading systemCarcinomaGrade groupTumorsPathologistsScoresGradingKappa coefficientBiopsyHistologyCoefficient kappa
2000
Visual estimate of the percentage of carcinoma is an independent predictor of prostate carcinoma recurrence after radical prostatectomy
Carvalhal G, Humphrey P, Thorson P, Yan Y, Ramos C, Catalona W. Visual estimate of the percentage of carcinoma is an independent predictor of prostate carcinoma recurrence after radical prostatectomy. Cancer 2000, 89: 1308-1314. PMID: 11002227, DOI: 10.1002/1097-0142(20000915)89:6<1308::aid-cncr16>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsPercentage of carcinomaGroup of patientsDisease recurrenceRadical prostatectomyRadical prostatectomy specimensIndependent predictorsPathologic stageGleason scoreTumor recurrenceProstate carcinomaProstatectomy specimensPreoperative prostate-specific antigen levelProstate-specific antigen levelKaplan-Meier product limit estimatesCox proportional hazards modelProstatic tissue specimensPathologic tumor stageKaplan-Meier methodRecurrence-free survivalSpecific antigen levelsImportant prognostic informationCox proportional hazardsProportional hazards modelProstate carcinoma recurrenceTumor size measurements
1998
Pseudohyperplastic Prostatic Adenocarcinoma
Humphrey P, Kaleem Z, Swanson P, Vollmer R. Pseudohyperplastic Prostatic Adenocarcinoma. The American Journal Of Surgical Pathology 1998, 22: 1239-1246. PMID: 9777986, DOI: 10.1097/00000478-199810000-00009.Peer-Reviewed Original ResearchConceptsCases of adenocarcinomaProstatic adenocarcinomaHyperplastic featuresNeedle biopsyProstate carcinoma growthUsual epithelial hyperplasiaProstatic needle biopsyLow Gleason scoreLow-grade carcinomaRadical prostatectomy specimensRadical prostatectomy tissueGleason pattern 2Cystic dilatationPathologic stagePrognostic implicationsTumor sizeGleason scoreHistologic gradePapillary infoldingsRadical prostatectomyUsual hyperplasiaHistologic variantsPrognostic informationProstatic carcinomaCarcinomatous fociPercentage of Free Serum Prostate-Specific Antigen as a Predictor of Pathologic Features of Prostate Cancer in a Screening Population fn1fn1This study was supported in part by a grant from Hybritech Incorporated, San Diego, California.
Arcangeli C, Humphrey P, Smith D, Harmon T, Shepherd D, Keetch D, Catalona W. Percentage of Free Serum Prostate-Specific Antigen as a Predictor of Pathologic Features of Prostate Cancer in a Screening Population fn1fn1This study was supported in part by a grant from Hybritech Incorporated, San Diego, California. Urology 1998, 51: 558-565. PMID: 9586607, DOI: 10.1016/s0090-4295(98)00035-1.Peer-Reviewed Original ResearchConceptsProstate-specific antigenProstate cancerPathologic featuresFree serum prostate-specific antigenSerum prostate-specific antigenFree prostate-specific antigenCancerous surgical marginsProstate cancer screeningPercentage of cancerRadical prostatectomy specimenHarmless cancersPreoperative predictorsWatchful waitingSurgical marginsCapsular penetrationProstatic capsuleGleason scoreCancer screeningRadical prostatectomyProstatectomy specimenTumor volumeFPSAClinical practiceCancerScreening evaluation
1996
Clinical and Pathological Features of Hereditary Prostate Cancer
Keetch D, Humphrey P, Smith D, Stahl D, Catalona W. Clinical and Pathological Features of Hereditary Prostate Cancer. Journal Of Urology 1996, 155: 1841-1843. PMID: 8618269, DOI: 10.1016/s0022-5347(01)66024-5.Peer-Reviewed Original ResearchConceptsHereditary prostate cancerSporadic prostate cancerProstate cancerPathological featuresGleason scoreSerum prostate-specific antigen (PSA) concentrationProstate-specific antigen concentrationDate of surgeryMean Gleason scoreSpecific antigen concentrationLow Gleason scoreHereditary diseaseRadical prostatectomy specimensFamily historyPathological differencesProstatectomy specimensMedian percentageSporadic carcinomasCancerAntigen concentrationSporadic cancersCarcinomaMenDiseaseScoresClinical and Pathological Features of Hereditary Prostate Cancer
Keetch D, Humphrey P, Smith D, Stahl D, Catalona W. Clinical and Pathological Features of Hereditary Prostate Cancer. Journal Of Urology 1996, 155: 1841-1842.. DOI: 10.1097/00005392-199606000-00004.Peer-Reviewed Original ResearchHereditary prostate cancerSporadic prostate cancerProstate cancerPathological featuresGleason scoreSerum prostate-specific antigen (PSA) concentrationProstate-specific antigen concentrationDate of surgeryMean Gleason scoreSpecific antigen concentrationLow Gleason scoreHereditary diseaseRadical prostatectomy specimensFamily historyPathological differencesAbstract PurposeProstatectomy specimensMedian percentageSporadic carcinomasCancerAntigen concentrationSporadic cancersCarcinomaMenDiseaseProspective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based Screening
Humphrey P, Keetch D, Smith D, Shepherd D, Catalona W. Prospective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based Screening. Journal Of Urology 1996, 155: 816-820. PMID: 8583583, DOI: 10.1016/s0022-5347(01)66316-x.Peer-Reviewed Original ResearchConceptsProstate-specific antigenSerum prostate-specific antigenPathological featuresProstatic carcinomaSpecific antigenOrgan-confined prostate carcinomaCancerous surgical marginsGleason histological gradeIntraglandular tumor extentMost prostatic cancersMost prostatic carcinomasSurgical margin statusRadical prostatectomy specimensExtracapsular carcinomaAdvanced diseaseMargin statusSurgical marginsGleason scoreHistological gradePathological stageSurgical specimenProspective dataProstatic cancerTumor extentProspective characterizationProspective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based Screening
Humphrey P, Keetch D, Smith D, Shepherd D, Catalona W. Prospective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based Screening. Journal Of Urology 1996, 155: 816-820.. DOI: 10.1097/00005392-199603000-00004.Peer-Reviewed Original ResearchProstate-specific antigenSerum prostate-specific antigenPathological featuresProstatic carcinomaSpecific antigenOrgan-confined prostate carcinomaCancerous surgical marginsGleason histological gradeIntraglandular tumor extentMost prostatic cancersMost prostatic carcinomasSurgical margin statusRadical prostatectomy specimensExtracapsular carcinomaAdvanced diseaseMargin statusSurgical marginsGleason scoreHistological gradePathological stageSurgical specimenProspective dataProstatic cancerTumor extentProspective characterization
1988
The ratio of prostate chips with cancer:A new measure of tumor extent and its relationship to grade and prognosis
Humphrey P, Vollmer R. The ratio of prostate chips with cancer:A new measure of tumor extent and its relationship to grade and prognosis. Human Pathology 1988, 19: 411-418. PMID: 3366451, DOI: 10.1016/s0046-8177(88)80490-8.Peer-Reviewed Original ResearchConceptsProstate cancerAdditive prognostic informationStage of tumorGleason histologic scoreChoice of patientsChance of deathCurative surgeryExtensive diseaseLocalized diseaseTransurethral prostatectomyGleason scoreProstate chipsPrognostic informationTumor extentHistologic scoresPatientsCancerLong-term failureDiseaseReliable predictorScoresInitial studyTotal numberPrognosticatorProstatectomy