2023
SLC26A1 is a major determinant of sulfate homeostasis in humans
Pfau A, López-Cayuqueo K, Scherer N, Wuttke M, Wernstedt A, Fassrainer D, Smith D, van de Kamp J, Ziegeler K, Eckardt K, Luft F, Aronson P, Köttgen A, Jentsch T, Knauf F. SLC26A1 is a major determinant of sulfate homeostasis in humans. Journal Of Clinical Investigation 2023, 133: e161849. PMID: 36719378, PMCID: PMC9888379, DOI: 10.1172/jci161849.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnion Transport ProteinsAntiportersHomeostasisHumansIon TransportMiceMice, KnockoutSulfate TransportersSulfatesConceptsSulfate homeostasisIntervertebral disc disordersWhole-exome sequencingMajor determinantBack painPatient presentingMusculoskeletal healthDisc disordersPlasma sulfateSulfate reabsorptionFunctional expression assaysCartilage healthHomozygous mutationPotential targetPopulation studiesNumerous physiological processesRecent evidenceExome analysisHomeostasisHyposulfatemiaExpression assaysPivotal roleClinical geneticsAdditional variantsHumans
2012
Sat1 is dispensable for active oxalate secretion in mouse duodenum
Ko N, Knauf F, Jiang Z, Markovich D, Aronson PS. Sat1 is dispensable for active oxalate secretion in mouse duodenum. American Journal Of Physiology - Cell Physiology 2012, 303: c52-c57. PMID: 22517357, PMCID: PMC3404526, DOI: 10.1152/ajpcell.00385.2011.Peer-Reviewed Original ResearchConceptsCalcium oxalate stonesMouse duodenumOxalate secretionOxalate stonesIntestinal oxalate secretionIntestinal oxalate transportSecretory fluxSAT1 expressionDisulfonic stilbene DIDSDuodenumTransporter 1SecretionMiceHyperoxalemiaBasolateral solutionHyperoxaluriaBasolateral transportersBicarbonate productionOxalate transportBasolateral membraneSAT1Apical membraneComplete removalMedium concentration
2009
Prestin's Anion Transport and Voltage-Sensing Capabilities Are Independent
Bai JP, Surguchev A, Montoya S, Aronson PS, Santos-Sacchi J, Navaratnam D. Prestin's Anion Transport and Voltage-Sensing Capabilities Are Independent. Biophysical Journal 2009, 96: 3179-3186. PMID: 19383462, PMCID: PMC2718310, DOI: 10.1016/j.bpj.2008.12.3948.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnalysis of VarianceAnimalsAnion Transport ProteinsAntiportersCarbon RadioisotopesChloridesCHO CellsCricetinaeCricetulusElectric CapacitanceFormatesGerbillinaeIon TransportMiceMutation, MissenseOxalatesPatch-Clamp TechniquesSalicylatesSulfate TransportersConceptsClosest phylogenetic relativesTransmembrane regionSLC26 anion transporter familyMammalian outer hair cellsMembrane protein prestinPrestin's motor functionAnion transportPhylogenetic relativesAnion transporter familyTransporter familyProtein prestinChloride-binding siteGating charge movementPrestinCharge movementHair cellsOuter hair cellsResiduesMechanistic conceptsVoltage sensingTransport capabilityCellsVoltage sensorPrevious observationsUptake studies
2006
Regulation of anion exchanger Slc26a6 by protein kinase C
Hassan HA, Mentone S, Karniski LP, Rajendran VM, Aronson PS. Regulation of anion exchanger Slc26a6 by protein kinase C. American Journal Of Physiology - Cell Physiology 2006, 292: c1485-c1492. PMID: 17151144, DOI: 10.1152/ajpcell.00447.2006.Peer-Reviewed Original ResearchMeSH KeywordsAcetophenonesAnimalsAnion Transport ProteinsAntiportersBenzopyransBiological Transport, ActiveCarbazolesCell MembraneChloridesCytoplasmEnzyme ActivationFemaleFormatesIn Vitro TechniquesIndolesMaleimidesMiceOocytesOxalatesProtein Kinase C-deltaProtein TransportSulfate TransportersTetradecanoylphorbol AcetateXenopusConceptsPKC activationOxalate secretionIntestinal oxalate secretionFormate exchangeRenal proximal tubulesAnion exchanger pendrinPancreatic ductExchanger pendrinProximal tubulesSmall intestineSLC26A6 expressionNaCl reabsorptionCalcium independentSimilar extentPotential rolePKC-delta activationProtein kinase CActivationSecretionSlc26a6Immunofluorescence microscopyXenopus oocytesPMAPhysiological significanceOocyte plasma membrane
2002
Specificity of Anion Exchange Mediated by Mouse Slc26a6*
Jiang Z, Grichtchenko II, Boron WF, Aronson PS. Specificity of Anion Exchange Mediated by Mouse Slc26a6*. Journal Of Biological Chemistry 2002, 277: 33963-33967. PMID: 12119287, DOI: 10.1074/jbc.m202660200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnion Transport ProteinsAntiportersBicarbonatesChloridesFormatesMiceOxalatesSulfate TransportersXenopusConceptsProximal tubule cellsP-aminohippurateTubule cellsOxalate-sulfate exchangeTransport of oxalatePH recordingRenal tubular fluidTubular fluidVoltage-clamp measurementsBrush border membraneFormate exchangeOxalate exchangeMeasurement of uptakeClamp measurementsBorder membraneSlc26a6Two-electrode voltage clamp measurementsXenopus oocytesPresent studyHigh oxalate concentrationsApical membraneOocytesMouse orthologueCellsCFEX
1989
The Renal Proximal Tubule: A Model for Diversity of Anion Exchangers and Stilbene-sensitive Anion Transporters
Aronson PS. The Renal Proximal Tubule: A Model for Diversity of Anion Exchangers and Stilbene-sensitive Anion Transporters. Annual Review Of Physiology 1989, 51: 419-441. PMID: 2653190, DOI: 10.1146/annurev.ph.51.030189.002223.Commentaries, Editorials and Letters
1988
Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles.
Kuo SM, Aronson PS. Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles. Journal Of Biological Chemistry 1988, 263: 9710-9717. PMID: 3384817, DOI: 10.1016/s0021-9258(19)81576-4.Peer-Reviewed Original Research4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAnimalsAnion Transport ProteinsAntiportersBicarbonatesBiological TransportCarrier ProteinsCell MembraneChloridesElectrochemistryHydrogen-Ion ConcentrationKidney CortexKineticsLactatesLactic AcidMaleMembrane PotentialsOxalatesOxalic AcidPotassiumRabbitsSulfate TransportersSulfatesValinomycin