2019
Host serum iron modulates dengue virus acquisition by mosquitoes
Zhu Y, Tong L, Nie K, Wiwatanaratanabutr I, Sun P, Li Q, Yu X, Wu P, Wu T, Yu C, Liu Q, Bian Z, Wang P, Cheng G. Host serum iron modulates dengue virus acquisition by mosquitoes. Nature Microbiology 2019, 4: 2405-2415. PMID: 31527795, DOI: 10.1038/s41564-019-0555-x.Peer-Reviewed Original ResearchConceptsSerum ironDengue virusVirus acquisitionDengue virus infectionIron-deficient miceDengue virus prevalenceIron metabolism pathwaysViral loadIron supplementationA. aegypti mosquitoesHigh prevalenceVirus infectionArbovirus infectionHuman donorsIron deficiencyInfectionBlood componentsGut epitheliumReactive oxygen speciesSusceptibility of mosquitoesVirus prevalenceAegypti mosquitoesBlood mealHuman bloodVirus
2018
A Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses
Wu P, Sun P, Nie K, Zhu Y, Shi M, Xiao C, Liu H, Liu Q, Zhao T, Chen X, Zhou H, Wang P, Cheng G. A Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses. Cell Host & Microbe 2018, 25: 101-112.e5. PMID: 30595552, DOI: 10.1016/j.chom.2018.11.004.Peer-Reviewed Original ResearchConceptsArboviral infectionsCommensal bacteriumGut bacteriaDengue virus infectionGut commensal bacteriumCultivable gut bacteriaAedes aegypti mosquitoesVirus infectionViral disseminationAntibiotic depletionIntestinal tractOral introductionGut microbiomeGut epitheliumInfectionMembrane-bound mucinsHuman virusesAegypti mosquitoesHematophagous vectorsVector competenceArbovirusesField mosquitoesSerratia marcescensMosquitoesVirus
2017
A Mesh–Duox pathway regulates homeostasis in the insect gut
Xiao X, Yang L, Pang X, Zhang R, Zhu Y, Wang P, Gao G, Cheng G. A Mesh–Duox pathway regulates homeostasis in the insect gut. Nature Microbiology 2017, 2: 17020. PMID: 28248301, PMCID: PMC5332881, DOI: 10.1038/nmicrobiol.2017.20.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsDrosophila melanogasterDual OxidasesGastrointestinal MicrobiomeGastrointestinal TractHomeostasisMembrane ProteinsSignal TransductionConceptsInsect gutERK phosphorylation cascadeCentral homeostatic mechanismDrosophila melanogasterMetazoan gutComplex communitiesPhosphorylation cascadeBacterial microbiomeDual oxidaseDuox expressionGut bacteriaGut bacterial microbiomeBlood mealHomeostasisBacterial microorganismsAedes aegyptiPathwayHomeostatic mechanismsMicroorganismsPhysiological changesGutExpressionMelanogasterImportant roleDynamic changes
2016
Mosquito C-type lectins maintain gut microbiome homeostasis.
Pang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology 2016, 1: 16023. PMID: 27572642, DOI: 10.1038/nmicrobiol.2016.23.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsCulexGastrointestinal TractHomeostasisImmune EvasionLectins, C-TypeMicrobial ViabilityMicrobiotaSymbiosisConceptsC-type lectinMammalian host immune systemHost immune systemAntimicrobial peptidesMajor mosquito vectorsCommensal bacteriaEvolutionary interactionsMultiple bacterial strainsSymbiotic bacteriaGut microbiomeGut microbial floraGut microbiome homeostasisFacilitate colonizationImmune systemGut commensal bacteriaMicrobial floraBacterial surfaceMicrobiome homeostasisAntagonistic relationshipBacterial strainsHomeostasisA. aegyptiMicrobiomeHost immune responseMosquito vectors