2024
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling
Harrison A, Yang D, Cahoon J, Geng T, Cao Z, Karginov T, Hu Y, Li X, Chiari C, Qyang Y, Vella A, Fan Z, Vanaja S, Rathinam V, Witczak C, Bogan J, Wang P. UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling. Nature Immunology 2024, 25: 2234-2246. PMID: 39567760, DOI: 10.1038/s41590-024-02004-7.Peer-Reviewed Original Research
2021
Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis
Jiao B, An C, Tran M, Du H, Wang P, Zhou D, Wang Y. Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis. Frontiers In Immunology 2021, 12: 735014. PMID: 34512669, PMCID: PMC8426438, DOI: 10.3389/fimmu.2021.735014.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseFolic acid administrationUnilateral ureteral obstructionRenal fibrosisM2 macrophage polarizationMacrophage polarizationUreteral obstructionFibroblast activationAcid administrationKidney functionKidney diseaseKidney fibrosisPreserves kidney functionSTAT6 activationVehicle-treated miceFolic acid nephropathyExperimental murine modelAlternative macrophage polarizationWild-type miceNovel therapeutic approachesExtracellular matrix protein productionSTAT6 inhibitorMatrix protein productionAS1517499Effective therapyUBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling.
Ketkar H, Harrison A, Graziano V, Geng T, Yang L, Vella A, Wang P. UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling. The Journal Of Immunology 2021, 206: 2682-2691. PMID: 34021047, PMCID: PMC8164993, DOI: 10.4049/jimmunol.1901337.Peer-Reviewed Original ResearchConceptsTyrosine kinase 2Domain-containing proteinsExpression of hundredsComplex cellular regulationRNA viral replicationJAK/STATCellular regulationType I/III IFNsKinase 2JAK/Type I/III IFNProtein 6IFN expressionGenesViral infectionSignalingExpressionViral replicationExpression of IFNCellsType IProteinSTATOverexpressionDeletion
2020
CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses
Lin T, Geng T, Harrison AG, Yang D, Vella AT, Fikrig E, Wang P. CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses. Viruses 2020, 12: 1252. PMID: 33147869, PMCID: PMC7692144, DOI: 10.3390/v12111252.Peer-Reviewed Original ResearchConceptsChikungunya virusAlphaviral arthritisArthritogenic alphavirusesLargest immune cell populationMacrophages/T cellsImmune cell populationsInflammatory immune responseLow viral loadWild-type miceO'nyong-nyong virusWild-type animalsRheumatic manifestationsImmune infiltratesViral loadT cellsImmune responseAlphaviral diseaseArthritic diseasesTherapeutic targetCXCL10PathogenesisViral RNACell populationsArthritisFootpad
2018
UBXN3B positively regulates STING-mediated antiviral immune responses
Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, Geng T, Mordue DG, Fujimoto T, Cheng G, You F, Lin R, Fikrig E, Wang P. UBXN3B positively regulates STING-mediated antiviral immune responses. Nature Communications 2018, 9: 2329. PMID: 29899553, PMCID: PMC5998066, DOI: 10.1038/s41467-018-04759-8.Peer-Reviewed Original ResearchConceptsUbiquitin regulatory X domain-containing proteinAntiviral immune responseImmune responseDeficient immune responseDomain-containing proteinsInterferon genes (STING) signalingVesicular stomatitis virus infectionDiverse biological processesStomatitis virus infectionPhosphorylation of TBK1Physiological evidenceHerpes simplex virus 1Cre-loxP approachSimplex virus 1Virus infectionAdult miceGene signalingHSV-1Biological processesPhysiological functionsVirus 1MicePrimary cellsConsequent recruitmentResponseFoot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1
Sun P, Zhang S, Qin X, Chang X, Cui X, Li H, Zhang S, Gao H, Wang P, Zhang Z, Luo J, Li Z. Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1. Autophagy 2018, 14: 336-346. PMID: 29166823, PMCID: PMC5902195, DOI: 10.1080/15548627.2017.1405187.Peer-Reviewed Original ResearchConceptsCapsid protein VP2FMDV infectionProtein VP2Polyglutamine expansion proteinsMacroautophagy/autophagyMammalian cell linesPrecise molecular mechanismsFMDV capsid proteinsNatural host cellsInhibition of autophagyCloven-hoofed animalsAutophagy inductionMolecular mechanismsAutophagy processHost cellsAkt-mTORMouth disease virusCapsid proteinViral replicationAutophagyFMDV replicationHSPB1InfectionCell linesVP2
2017
Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system
Zhu Y, Zhang R, Zhang B, Zhao T, Wang P, Liang G, Cheng G. Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system. Nature Communications 2017, 8: 1262. PMID: 29093445, PMCID: PMC5665997, DOI: 10.1038/s41467-017-01244-6.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsArbovirusesBloodBunyamwera virusCulexDengue VirusEncephalitis Virus, CaliforniaEncephalitis Virus, JapaneseGABA-A Receptor AntagonistsGamma-Aminobutyric AcidHumansImmunity, InnateMosquito VectorsReceptors, GABA-ARNA, Double-StrandedSemliki forest virusSignal TransductionSindbis VirusVirus ReplicationConceptsGABAergic systemArboviral infectionsArbovirus replicationInfection of mosquitoesAntiviral innate immunityIngestion of bloodBlood protein digestionBlood mealGABA signalingBlood meal acquisitionGABAergic pathwayGABAA receptorsInnate immunityOral introductionGlutamic acidHematophagous insectsInfectionHuman virusesVirus acquisitionSpecific inhibitorGABAProtein digestionCommon mechanismHematophagous natureActivationAn essential role of PI3K in the control of West Nile virus infection
Wang L, Yang L, Fikrig E, Wang P. An essential role of PI3K in the control of West Nile virus infection. Scientific Reports 2017, 7: 3724. PMID: 28623344, PMCID: PMC5473900, DOI: 10.1038/s41598-017-03912-5.Peer-Reviewed Original ResearchConceptsWest Nile virus infectionPI3K inhibitorsPI3KVirus infectionImmune responseK inhibitorsType I IFN responseAntiviral immune responseI IFN responseCatalytic subunit p110δTNF-α protein productionPrimary mouse macrophagesFlaviviral infectionsAntiviral immunityIFN responseViral titersClass I PI3KAntiviral roleMRNA expressionPI3K activityIFNProtein expressionInfectionMouse macrophagesCell proliferationA Mesh–Duox pathway regulates homeostasis in the insect gut
Xiao X, Yang L, Pang X, Zhang R, Zhu Y, Wang P, Gao G, Cheng G. A Mesh–Duox pathway regulates homeostasis in the insect gut. Nature Microbiology 2017, 2: 17020. PMID: 28248301, PMCID: PMC5332881, DOI: 10.1038/nmicrobiol.2017.20.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsDrosophila melanogasterDual OxidasesGastrointestinal MicrobiomeGastrointestinal TractHomeostasisMembrane ProteinsSignal TransductionConceptsInsect gutERK phosphorylation cascadeCentral homeostatic mechanismDrosophila melanogasterMetazoan gutComplex communitiesPhosphorylation cascadeBacterial microbiomeDual oxidaseDuox expressionGut bacteriaGut bacterial microbiomeBlood mealHomeostasisBacterial microorganismsAedes aegyptiPathwayHomeostatic mechanismsMicroorganismsPhysiological changesGutExpressionMelanogasterImportant roleDynamic changes
2013
UBXN1 Interferes with Rig-I-like Receptor-Mediated Antiviral Immune Response by Targeting MAVS
Wang P, Yang L, Cheng G, Yang G, Xu Z, You F, Sun Q, Lin R, Fikrig E, Sutton RE. UBXN1 Interferes with Rig-I-like Receptor-Mediated Antiviral Immune Response by Targeting MAVS. Cell Reports 2013, 3: 1057-1070. PMID: 23545497, PMCID: PMC3707122, DOI: 10.1016/j.celrep.2013.02.027.Peer-Reviewed Original ResearchConceptsAntiviral immune responseInnate immune responseImmune responseLike receptorsSystemic antiviral immune responsesVirus-induced innate immune responsesDengue virus infectionType I interferon responseI interferon responseRNA virusesVirus infectionViral infectionStrong inhibitory effectViral replicationVirus replicationInterferon responseRNA virus replicationInhibitory effectWest NileMAVSVesicular stomatitisInfectionAdaptor moleculeFamily membersReceptors
2010
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I
Wang P, Arjona A, Zhang Y, Sultana H, Dai J, Yang L, LeBlanc PM, Doiron K, Saleh M, Fikrig E. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nature Immunology 2010, 11: 912-919. PMID: 20818395, PMCID: PMC3712356, DOI: 10.1038/ni.1933.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaspase 12Cells, CulturedDEAD Box Protein 58DEAD-box RNA HelicasesDNA-Binding ProteinsFibroblastsImmunity, InnateInterferon Type IMiceMice, Inbred C57BLMice, KnockoutNeuronsReceptors, VirusSignal TransductionTranscription FactorsUbiquitinationUbiquitin-Protein LigasesWest Nile FeverWest Nile virus