2024
A substitution at the cytoplasmic tail of the spike protein enhances SARS-CoV-2 infectivity and immunogenicity
Li Y, Zhang X, Tai W, Zhuang X, Shi H, Liao S, Yu X, Mei R, Chen X, Huang Y, Liu Y, Liu J, Liu Y, Zhu Y, Wang P, Tian M, Yu G, Li L, Cheng G. A substitution at the cytoplasmic tail of the spike protein enhances SARS-CoV-2 infectivity and immunogenicity. EBioMedicine 2024, 110: 105437. PMID: 39531918, DOI: 10.1016/j.ebiom.2024.105437.Peer-Reviewed Original ResearchS proteinCytoplasmic tailFERM-binding motifTrans-complementation systemSpike proteinAmino acid substitutionsProline-to-leucine substitutionSystematic bioinformatics analysisHigh-frequency mutationsSARS-CoV-2 virionsBinding motifAcid substitutionsSARS-CoV-2Natural selectionBioinformatics analysisEzrin/radixin/moesin proteinsMolecular mechanismsMutationsOmicron variantProteinVaccine developmentMRNA vaccinesGlobal disseminationSARS-CoV-2 Omicron sublineagesSublineages
2020
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis
Harrison AG, Lin T, Wang P. Mechanisms of SARS-CoV-2 Transmission and Pathogenesis. Trends In Immunology 2020, 41: 1100-1115. PMID: 33132005, PMCID: PMC7556779, DOI: 10.1016/j.it.2020.10.004.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Severe acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Coronavirus infectious disease 2019Respiratory syndrome coronavirus 2SARS-CoV-2 transmissionTissue tropismSyndrome coronavirus 2SARS-CoV-2 researchBroad tissue tropismCoronavirus 2Pathogenic coronavirusesDisease 2019Immune antagonismTherapeutic testingAnimal modelsViral pathogenesisVaccine developmentPathogenesisTropismFuture investigationsHuman population