2024
A mosquito salivary protein-driven influx of myeloid cells facilitates flavivirus transmission
Wang Z, Nie K, Liang Y, Niu J, Yu X, Zhang O, Liu L, Shi X, Wang Y, Feng X, Zhu Y, Wang P, Cheng G. A mosquito salivary protein-driven influx of myeloid cells facilitates flavivirus transmission. The EMBO Journal 2024, 43: 1690-1721. PMID: 38378891, PMCID: PMC11066113, DOI: 10.1038/s44318-024-00056-x.Peer-Reviewed Original ResearchMyeloid cellsExpression of neutrophil chemoattractantsViral transmissionInflux of myeloid cellsMosquito bite siteSalivary componentsInflux of neutrophilsSkin-resident macrophagesPotential prophylactic targetsFlavivirus transmissionNF-kB signalingMechanism of actionProphylactic targetsSystemic disseminationRecruits proteinsSalivary factorsLocal infectionNeutrophil chemoattractantMammalian hostsEfficient viral transmissionPhytochemical resveratrolDengue virusBite siteTransmission of ZikaProtein
2009
Antibodies against a Tick Protein, Salp15, Protect Mice from the Lyme Disease Agent
Dai J, Wang P, Adusumilli S, Booth CJ, Narasimhan S, Anguita J, Fikrig E. Antibodies against a Tick Protein, Salp15, Protect Mice from the Lyme Disease Agent. Cell Host & Microbe 2009, 6: 482-492. PMID: 19917502, PMCID: PMC2843562, DOI: 10.1016/j.chom.2009.10.006.Peer-Reviewed Original ResearchConceptsArthropod-borne pathogensTick-borne BorreliaTick salivary proteinsTick proteinsB. burgdorferiLyme diseaseDisease agentsTick-borne illnessB. burgdorferi infectionLyme disease agentHuman vaccinesSalp15Infection of miceB. burgdorferi antigensMicrobial toxinsMammalian hostsBorrelia burgdorferiPathogensMechanism of actionBurgdorferi infectionProtect miceMedical importanceBurgdorferiProtective capacityMice