2021
A human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoes
Zhu Y, Zhang C, Zhang L, Yang Y, Yu X, Wang J, Liu Q, Wang P, Cheng G. A human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoes. Cell Reports 2021, 37: 110091. PMID: 34910910, DOI: 10.1016/j.celrep.2021.110091.Peer-Reviewed Original Research
2019
Host serum iron modulates dengue virus acquisition by mosquitoes
Zhu Y, Tong L, Nie K, Wiwatanaratanabutr I, Sun P, Li Q, Yu X, Wu P, Wu T, Yu C, Liu Q, Bian Z, Wang P, Cheng G. Host serum iron modulates dengue virus acquisition by mosquitoes. Nature Microbiology 2019, 4: 2405-2415. PMID: 31527795, DOI: 10.1038/s41564-019-0555-x.Peer-Reviewed Original ResearchConceptsSerum ironDengue virusVirus acquisitionDengue virus infectionIron-deficient miceDengue virus prevalenceIron metabolism pathwaysViral loadIron supplementationA. aegypti mosquitoesHigh prevalenceVirus infectionArbovirus infectionHuman donorsIron deficiencyInfectionBlood componentsGut epitheliumReactive oxygen speciesSusceptibility of mosquitoesVirus prevalenceAegypti mosquitoesBlood mealHuman bloodVirusChikungunya Virus and (Re-) Emerging Alphaviruses
Wang P, Zhang R. Chikungunya Virus and (Re-) Emerging Alphaviruses. Viruses 2019, 11: 779. PMID: 31450552, PMCID: PMC6784149, DOI: 10.3390/v11090779.Peer-Reviewed Original ResearchArbovirus lifecycle in mosquito: acquisition, propagation and transmission
Wu P, Yu X, Wang P, Cheng G. Arbovirus lifecycle in mosquito: acquisition, propagation and transmission. Expert Reviews In Molecular Medicine 2019, 21: e1. PMID: 30862324, DOI: 10.1017/erm.2018.6.Peer-Reviewed Original ResearchConceptsDistinct host environmentsBlood mealHaematophagous vectorsVertebrate animalsVertebrate hostsMosquito-Borne VirusesHuman diseasesNaive mosquitoesHost environmentMosquito tissuesNext blood mealInfected hostVector factorsMosquitoesPathogenic virusesHostVirus reservoirVirus survivalRecent studiesAetiological agentVirusTissueMealDisease
2017
Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system
Zhu Y, Zhang R, Zhang B, Zhao T, Wang P, Liang G, Cheng G. Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system. Nature Communications 2017, 8: 1262. PMID: 29093445, PMCID: PMC5665997, DOI: 10.1038/s41467-017-01244-6.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsArbovirusesBloodBunyamwera virusCulexDengue VirusEncephalitis Virus, CaliforniaEncephalitis Virus, JapaneseGABA-A Receptor AntagonistsGamma-Aminobutyric AcidHumansImmunity, InnateMosquito VectorsReceptors, GABA-ARNA, Double-StrandedSemliki forest virusSignal TransductionSindbis VirusVirus ReplicationConceptsGABAergic systemArboviral infectionsArbovirus replicationInfection of mosquitoesAntiviral innate immunityIngestion of bloodBlood protein digestionBlood mealGABA signalingBlood meal acquisitionGABAergic pathwayGABAA receptorsInnate immunityOral introductionGlutamic acidHematophagous insectsInfectionHuman virusesVirus acquisitionSpecific inhibitorGABAProtein digestionCommon mechanismHematophagous natureActivationA Mesh–Duox pathway regulates homeostasis in the insect gut
Xiao X, Yang L, Pang X, Zhang R, Zhu Y, Wang P, Gao G, Cheng G. A Mesh–Duox pathway regulates homeostasis in the insect gut. Nature Microbiology 2017, 2: 17020. PMID: 28248301, PMCID: PMC5332881, DOI: 10.1038/nmicrobiol.2017.20.Peer-Reviewed Original ResearchConceptsInsect gutERK phosphorylation cascadeCentral homeostatic mechanismDrosophila melanogasterMetazoan gutComplex communitiesPhosphorylation cascadeBacterial microbiomeDual oxidaseDuox expressionGut bacteriaGut bacterial microbiomeBlood mealHomeostasisBacterial microorganismsAedes aegyptiPathwayHomeostatic mechanismsMicroorganismsPhysiological changesGutExpressionMelanogasterImportant roleDynamic changes