2022
A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry
Tong L, Wang L, Liao S, Xiao X, Qu J, Wu C, Zhu Y, Tai W, Huang Y, Wang P, Li L, Zhang R, Xiang Y, Cheng G. A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry. MBio 2022, 13: e01485-22. PMID: 35862773, PMCID: PMC9426596, DOI: 10.1128/mbio.01485-22.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 variantsSARS-CoV-2 infectionPotent antiviral activitySevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Inhibits SARS-CoV-2 infectionAntiviral activityRespiratory syndrome coronavirus 2Retinoic acidLower respiratory tractSyndrome coronavirus 2Coronavirus disease 2019Multiple organ systemsVitamin A derivativesCOVID-19 diseaseSpike protein trimerS trimerCoronavirus 2Respiratory tractDisease 2019Vitamin AActive metaboliteOrgan systemsEtiological agentTherapeutic antibodies
2019
Lack of efficacy of ivermectin for prevention of a lethal Zika virus infection in a murine system
Ketkar H, Yang L, Wormser GP, Wang P. Lack of efficacy of ivermectin for prevention of a lethal Zika virus infection in a murine system. Diagnostic Microbiology And Infectious Disease 2019, 95: 38-40. PMID: 31097261, PMCID: PMC6697611, DOI: 10.1016/j.diagmicrobio.2019.03.012.Peer-Reviewed Original ResearchConceptsZika virus infectionAnti-Zika virus activityVirus infectionAnimal modelsZika virusLethal Zika Virus InfectionIFNAR1 knockout miceZika virus strainLack of efficacyEffectiveness of ivermectinLethal infectionKnockout miceVirus activityAntiviral activityMurine systemVirus strainsDrug ivermectinInfectionIvermectinStudy limitationsPreventionVirusSenegal strainMice
2018
Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3
Wang K, Zou C, Wang X, Huang C, Feng T, Pan W, Wu Q, Wang P, Dai J. Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3. PLOS Pathogens 2018, 14: e1007287. PMID: 30142214, PMCID: PMC6126873, DOI: 10.1371/journal.ppat.1007287.Peer-Reviewed Original ResearchMeSH KeywordsA549 CellsAnimalsAnophelesCells, CulturedDengue VirusGene Expression RegulationHEK293 CellsHeLa CellsHuman Umbilical Vein Endothelial CellsHumansInterferon Type IMiceProtein Processing, Post-TranslationalRNA HelicasesSerine EndopeptidasesTripartite Motif ProteinsUbiquitinationUbiquitin-Protein LigasesUp-RegulationViral Nonstructural ProteinsVirus ReplicationConceptsInterferon-stimulated genesI interferonNonstructural protein 3DENV replicationMost interferon-stimulated genesProtein 3Dengue virus infectionDengue virus replicationType I interferonViral nonstructural protein 3DENV infectionImmunocompetent miceVirus infectionViral infectionAntiviral activityVirus replicationVivo studiesInfectionTripartite motif (TRIM) proteinsTRIM family membersViral nonstructural proteinsFamily membersNonstructural proteinsTRIM69E3 ubiquitin ligase activity