Extragonadal Yolk Sac Tumor Limited to the Myometrium: Report of a Case With Potential Fertility Preservation and Molecular Analysis Suggesting Germ Cell Origin
Simpson S, Simoni M, Hui P, Taylor H, Buza N. Extragonadal Yolk Sac Tumor Limited to the Myometrium: Report of a Case With Potential Fertility Preservation and Molecular Analysis Suggesting Germ Cell Origin. International Journal Of Gynecological Pathology 2020, 39: 247-253. PMID: 31033797, DOI: 10.1097/pgp.0000000000000601.Peer-Reviewed Original ResearchConceptsYolk sac tumorExtragonadal yolk sac tumorGerm cell originFuture fertilityIntraoperative frozen section evaluationCell originPatient's strong desirePostpubertal female patientsEvidence of diseaseFrozen section evaluationMarked nuclear atypiaClear treatment algorithmRare malignant neoplasmHigh-grade malignancyEosinophilic hyaline globulesNext-generation sequencing resultsAdjuvant chemotherapySurgical stagingAbdominal myomectomyNulligravid womenIrregular bleedingUterine closureWedge resectionYounger patientsFemale patients