Featured Publications
The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons
Chung CY, Licznerski P, Alavian KN, Simeone A, Lin Z, Martin E, Vance J, Isacson O. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain 2010, 133: 2022-2031. PMID: 20573704, PMCID: PMC2892944, DOI: 10.1093/brain/awq142.Peer-Reviewed Original ResearchConceptsMidbrain dopaminergic neuronsVentral mesencephalic culturesTranscription factor orthodenticle homeobox 2Orthodenticle homeobox 2Dopaminergic neuronsMesencephalic culturesShort hairpin RNAHomeobox 2A10 dopaminergic neuronsCyclase-activating peptideHairpin RNAConditional knockout miceVentral mesencephalonNeuronal vulnerabilityDopaminergic projectionsAxonal projectionsParkinson's diseaseAdult miceKnockout miceMN9D cellsNeuropilin-2Elevated geneNeuronsNeuropilin-1Human midbrain
2014
The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed
Alavian KN, Jeddi S, Naghipour SI, Nabili P, Licznerski P, Tierney TS. The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed. Journal Of Biomedical Science 2014, 21: 27. PMID: 24685177, PMCID: PMC3998737, DOI: 10.1186/1423-0127-21-27.Peer-Reviewed Original ResearchConceptsMesencephalic dopaminergic neuronsDopaminergic neuronsParkinson's diseaseSubstantia nigra pars compactaMidbrain dopaminergic neuronsLong-term survivalPars compactaSet of neuronsPathological hallmarkNormal physiological functionNeurotransmitter identityNeurophysiological functionsNeuronsDiseaseLifelong maintenanceCurrent reviewTranscription factorsNurr1DegenerationPhysiological functionsReviewFactorsSpecific vulnerabilitiesMidbrainCompacta