Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development
Komai S, Licznerski P, Cetin A, Waters J, Denk W, Brecht M, Osten P. Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development. Nature Neuroscience 2006, 9: 1125-1133. PMID: 16921372, DOI: 10.1038/nn1752.Peer-Reviewed Original ResearchConceptsSomatodendritic excitabilityExperience-dependent developmentLayer 2/3 pyramidal neuronsCortical networksSensory responsesRat somatosensory cortexNormal cortical developmentCortical sensory responsesDevelopmental strengtheningPostsynaptic excitabilityPyramidal neuronsSomatosensory cortexCortical neuronsBarrel cortexPostsynaptic neuronsCortical developmentSensory cortexSensory pathwaysSensory responsivenessSynaptic strengthExcitabilitySensory deprivationCortexNeuronsVivo recordingsIncomplete and Inaccurate Vocal Imitation after Knockdown of FoxP2 in Songbird Basal Ganglia Nucleus Area X
Haesler S, Rochefort C, Georgi B, Licznerski P, Osten P, Scharff C. Incomplete and Inaccurate Vocal Imitation after Knockdown of FoxP2 in Songbird Basal Ganglia Nucleus Area X. PLOS Biology 2007, 5: e321. PMID: 18052609, PMCID: PMC2100148, DOI: 10.1371/journal.pbio.0050321.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasal GangliaFinchesForkhead Transcription FactorsLentivirusMaleMolecular Sequence DataRNA InterferenceVocalization, AnimalConceptsDevelopmental verbal dyspraxiaVocal imitationKnockdown of FoxP2Comprehension of grammarVocal motor learningSong learningWord productionMutations of FOXP2Neural parallelsLanguage disordersHuman speechHuman languageMotor learningFluent productionVerbal dyspraxiaSong ontogenyTutor songSpeechImitationBasal ganglia structuresAcoustic structureLearningGanglia structuresBasal gangliaFoxP2 levels