Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress
Son H, Banasr M, Choi M, Chae SY, Licznerski P, Lee B, Voleti B, Li N, Lepack A, Fournier NM, Lee KR, Lee IY, Kim J, Kim JH, Kim YH, Jung SJ, Duman RS. Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 11378-11383. PMID: 22733766, PMCID: PMC3396528, DOI: 10.1073/pnas.1201191109.Peer-Reviewed Original ResearchConceptsChronic unpredictable stressAntidepressant actionAtrophy of dendritesDepressive-like behaviorAntidepressant treatment responseSymptoms of depressionExpression of neuritinActivity-dependent genesAntidepressant treatmentLimbic structuresHippocampal expressionUnpredictable stressTreatment responseMood disordersBehavioral deficitsNeuronal plasticityTreatment reversesAnxiety behaviorChronic stressNeuritinDendrite branchingUnique actionHippocampusNeuroplasticityModel of stressSelect Overexpression of Homer1a in Dorsal Hippocampus Impairs Spatial Working Memory
Celikel T, Marx V, Freudenberg F, Zivkovic A, Resnik E, Hasan MT, Licznerski P, Osten P, Rozov A, Seeburg PH, Schwarz MK. Select Overexpression of Homer1a in Dorsal Hippocampus Impairs Spatial Working Memory. Frontiers In Neuroscience 2007, 1: 97-110. PMID: 18982121, PMCID: PMC2518050, DOI: 10.3389/neuro.01.1.1.007.2007.Peer-Reviewed Original ResearchLong-term potentiationSynaptic plasticityCA3-CA1 long-term potentiationLong Homer isoformsPostsynaptic excitatory neuronsSpatial working memoryOverexpression of Homer1aDorsal hippocampusGlutamate receptorsExcitatory neuronsSynaptic transmissionCortical areasImpairs spatial working memoryHomer isoformsSimilar impairmentHomer1aLong HomersSpatial workingReference memorySpatial memoryHippocampusFunctional competitionImpairmentOverexpressionExpression of VenusA negative regulator of MAP kinase causes depressive behavior
Duric V, Banasr M, Licznerski P, Schmidt HD, Stockmeier CA, Simen AA, Newton SS, Duman RS. A negative regulator of MAP kinase causes depressive behavior. Nature Medicine 2010, 16: 1328-1332. PMID: 20953200, PMCID: PMC3066515, DOI: 10.1038/nm.2219.Peer-Reviewed Original Research