Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression
Licznerski P, Duman RS. Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression. Neuroscience 2012, 251: 33-50. PMID: 23036622, PMCID: PMC3566360, DOI: 10.1016/j.neuroscience.2012.09.057.Peer-Reviewed Original ResearchConceptsAxo-spinous synapsesAlters spine morphologyPathophysiology of depressionTreatment of depressionLimbic brain regionsEffective therapeutic agentExpression of prePlasticity-related proteinsStress-related illnessesBasic research studiesSynaptic machineryBehavioral deficitsDendritic spinesPsychiatric disordersAnimal modelsFunctional alterationsSynaptic plasticityBrain regionsSpine morphologyPrefrontal cortexTherapeutic agentsStress exposureNeuronal communicationBrain imagingSpine architectureActin/α-Actinin-Dependent Transport of AMPA Receptors in Dendritic Spines: Role of the PDZ-LIM Protein RIL
Schulz TW, Nakagawa T, Licznerski P, Pawlak V, Kolleker A, Rozov A, Kim J, Dittgen T, Köhr G, Sheng M, Seeburg PH, Osten P. Actin/α-Actinin-Dependent Transport of AMPA Receptors in Dendritic Spines: Role of the PDZ-LIM Protein RIL. Journal Of Neuroscience 2004, 24: 8584-8594. PMID: 15456832, PMCID: PMC6729893, DOI: 10.1523/jneurosci.2100-04.2004.Peer-Reviewed Original ResearchConceptsAMPA receptorsDendritic spinesLIM domain-containing proteinsDomain-containing proteinsActin-dependent mannerCultured neuronsPostsynaptic density fractionSynaptic AMPA receptorsLIM domainsPDZ domainProtein complexesActin cytoskeletonC-terminal peptideNovel regulationHeterologous cellsReceptor transportRILsExcitatory transmissionForebrain synaptosomesMiniature EPSCsSynaptic accumulationRat forebrainSynaptic sitesSynaptic surfaceReceptors