Placental Viral Infection Sensitizes to Endotoxin‐Induced Pre‐Term Labor: A Double Hit Hypothesis
Cardenas I, Mor G, Aldo P, Lang SM, Stabach P, Sharp A, Romero R, Mazaki‐Tovi S, Gervasi M, Means RE. Placental Viral Infection Sensitizes to Endotoxin‐Induced Pre‐Term Labor: A Double Hit Hypothesis. American Journal Of Reproductive Immunology 2010, 65: 110-117. PMID: 20712808, PMCID: PMC3025809, DOI: 10.1111/j.1600-0897.2010.00908.x.Peer-Reviewed Original ResearchConceptsPre-term labourPre-term deliveryDouble-hit hypothesisViral infectionPregnancy outcomesBacterial infectionsCytokine/chemokine profilesHit hypothesisConcurrent bacterial infectionFetal immune responsePro-inflammatory cytokinesWild-type miceHuman primary trophoblastsMurine gammaherpesvirus 68Fetal deathChemokine profilesPoor prognosisPregnant womenAdverse outcomesPregnant miceLPS treatmentImmune responseBacterial productsPrimary trophoblastsLow doses