2023
Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload
Kheyfets V, Kumar S, Heerdt P, Ichimura K, Brown R, Lucero M, Essafri I, Williams S, Stenmark K, Spiekerkoetter E. Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload. International Journal Of Molecular Sciences 2023, 24: 9746. PMID: 37298696, PMCID: PMC10253685, DOI: 10.3390/ijms24119746.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalGene Expression ProfilingHeart VentriclesHypertension, PulmonaryPulmonary EmbolismRatsTranscriptomeVentricular RemodelingConceptsPressure overloadChronic RV pressure overloadExperimental pulmonary hypertension modelsRV pressure overloadTime pointsPulmonary hypertension modelRV outflow tractTranscriptomic signaturesAcute pressure overloadRight ventricular tissueDifferent time pointsPulmonary embolismHypertension modelSevere PEAcute increaseInitial insultOutflow tractRight ventricleRV apexVentricular tissueControl tissuesRatsSeverityWeeksTissue
2017
Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution During Hemorrhagic Shock and Resuscitation in Adult Swine
Berlin DA, Peprah-Mensah H, Manoach S, Heerdt PM. Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution During Hemorrhagic Shock and Resuscitation in Adult Swine. Critical Care Medicine 2017, 45: e195-e201. PMID: 27749345, DOI: 10.1097/ccm.0000000000002071.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCardiac OutputDisease Models, AnimalMonitoring, PhysiologicResuscitationShock, HemorrhagicSwineThermodilutionConceptsNoninvasive cardiac output monitoringCardiac output monitoringThermodilution cardiac outputCardiac outputOutput monitoringArtery catheterHemorrhagic shockBolus thermodilutionIntermittent bolus thermodilutionFemoral artery catheterPulmonary artery catheterAdult porcine modelBlood pressure measurementsLaboratory animal investigationFour-quadrant plotLimits of agreementShed bloodBland-Altman analysisAnimal investigationsPlasma lactateThermodilution measurementsResuscitationYorkshire swineAdult swinePorcine model