2005
Anesthetic-Induced Alteration in Expression of Myocardial Calcium Cycling Proteins
Heerdt PM, H.S. The A, Markov NP. Anesthetic-Induced Alteration in Expression of Myocardial Calcium Cycling Proteins. Journal Of Cardiothoracic And Vascular Anesthesia 2005, 19: 340-344. PMID: 16130061, DOI: 10.1053/j.jvca.2005.02.007.Peer-Reviewed Original ResearchConceptsCalcium cycling proteinsCycling proteinsSarcolemmal sodium-calcium exchangerMolecular remodelingInduction of anesthesiaNew Zealand white rabbitsEnd-tidal halothaneGroups of rabbitsZealand white rabbitsSodium-calcium exchangerHalothane doseWestern blot analysisPerioperative interventionsTracheal intubationUniversity research laboratorySubtype 2aPrior treatmentWhite rabbits
2000
Isoflurane Pretreatment Ameliorates Postischemic Neurologic Dysfunction and Preserves Hippocampal Ca2+/Calmodulin-dependent Protein Kinase in a Canine Cardiac Arrest Model
Blanck T, Haile M, Xu F, Zhang J, Heerdt P, Veselis R, Beckman J, Kang R, Adamo A, Hemmings H. Isoflurane Pretreatment Ameliorates Postischemic Neurologic Dysfunction and Preserves Hippocampal Ca2+/Calmodulin-dependent Protein Kinase in a Canine Cardiac Arrest Model. Anesthesiology 2000, 93: 1285-1293. PMID: 11046218, DOI: 10.1097/00000542-200011000-00023.Peer-Reviewed Original ResearchMeSH KeywordsAnesthetics, InhalationAnimalsBlood PressureBlotting, WesternBrain DiseasesCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium-Calmodulin-Dependent Protein KinasesDogsFemaleHeart Arrest, InducedHeart RateHippocampusIschemic Attack, TransientIschemic PreconditioningIsofluraneNeuroprotective AgentsSynaptosomesConceptsNeurologic deficit scoreCanine cardiac arrest modelCardiac arrest modelDeficit scoresIschemic animalsCardiac arrestGlobal ischemiaStriatum of animalsEffective neuroprotective drugsIsoflurane pretreatmentNeurologic dysfunctionNeurologic functionHippocampal contentNeuroprotective effectsIsoflurane exposureHippocampal levelsIntensive careNeuroprotective drugsRat modelVentricular fibrillationInhalational anestheticsTreatment groupsBlinded evaluatorsCanine modelIschemia