2014
Regulation of Protein Phosphatase 1I by Cdc25C-associated Kinase 1 (C-TAK1) and PFTAIRE Protein Kinase*
Platholi J, Federman A, Detert JA, Heerdt P, Hemmings HC. Regulation of Protein Phosphatase 1I by Cdc25C-associated Kinase 1 (C-TAK1) and PFTAIRE Protein Kinase*. Journal Of Biological Chemistry 2014, 289: 23893-23900. PMID: 25028520, PMCID: PMC4156073, DOI: 10.1074/jbc.m114.557744.Peer-Reviewed Original ResearchConceptsProtein phosphatase 1IC-TAK1Protein kinaseKinase 1GSK-3Protein phosphatase 1Phosphatase activityPP-1cThr-72Multisite phosphorylationActivating residuesPhosphatase 1Regulatory subunitSer-86Ser-71Subsequent phosphorylationMajor endogenous formsInhibitor 2PhosphorylationKinaseCdc25CEndogenous formPFTK1ResiduesActivation
2007
Protein phosphatase‐1I activation in brain following cardiac arrest and resuscitation
Platholi J, Heerdt P, Tung H, Hemmings H. Protein phosphatase‐1I activation in brain following cardiac arrest and resuscitation. The FASEB Journal 2007, 21: a618-a619. DOI: 10.1096/fasebj.21.5.a618-d.Peer-Reviewed Original ResearchProtein phosphatase 1Cerebral ischemiaCellular energy metabolismPig brainApoptotic cell deathTransient global cerebral ischemiaPhosphatase 1Protein regulatorsGlobal cerebral ischemiaPP-1Major proteinsInhibitor 2Cell deathSubunit compositionEnergy metabolismIntact animal modelIonic balanceCardiac arrestAnimal modelsProtective mechanismBrainIschemiaDeathDependent formRegulator