Patrick Gallagher, MD, BS
Professor Emeritus of PediatricsDownloadHi-Res Photo
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Director, Yale Center for Blood Disorders
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Titles
Professor Emeritus of Pediatrics
Director, Yale Center for Blood Disorders
Appointments
Neonatal-Perinatal Medicine
EmeritusPrimary
Other Departments & Organizations
- Gallagher Lab
- Neonatal Transport Program
- Neonatal-Perinatal Medicine
- Newborn Special Care Unit
- Pathology and Molecular Medicine
- Pathology Research
- Pediatrics
- Rheumatic Diseases Research Core
- Yale Stem Cell Center
- Yale Ventures
- YCCEH
Education & Training
- Fellow - Molecular Hematology
- Yale University School of Medicine (1994)
- Fellow - Neonatal-Perinatal Medicine
- Yale University School of Medicine (1992)
- Chief Resident
- Children's Hospital Medical Center, University of Cincinnati (1989)
- Intern & Resident
- Children's Hospital Medical Center, University of Cincinnati (1988)
- MD
- Northeastern Ohio University (1985)
- BS
- Ohio State University (1976)
Research
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Overview
Dr. Gallagher has trained numerous undergraduate, graduate and medical students, MD and PhD postdoctoral fellows, and sabbatical faculty. Laboratory graduates hold positions throughout the world and trainees have
received awards and honors from local, regional, and national organizations. After serving as the PI on the Yale Neonatal/Perinatal Medicine T32 training grant for many years, he now participates in training grants in Genetics, Medicine, and Laboratory Medicine. He serves on the Department of Pediatrics Scholarship Oversight Committee (SOC). He has served on numerous individual SOCs as member or chair, as well as various medical and graduate school mentoring committees, PhD thesis committees, etc.
Medical Research Interests
Anemia, Sickle Cell; Diseases; Elliptocytosis, Hereditary; Erythropoiesis; Genetics; Genomics; Health Care; Hemoglobinopathies; Hydrops Fetalis; Information Science; Neonatology; Pathology; Pediatrics; Polycythemia; Pyruvate Kinase; Spherocytosis, Hereditary
ORCID
0000-0002-5424-0224
Research at a Glance
Yale Co-Authors
Frequent collaborators of Patrick Gallagher's published research.
Publications Timeline
A big-picture view of Patrick Gallagher's research output by year.
Research Interests
Research topics Patrick Gallagher is interested in exploring.
Vincent Schulz, PhD
Louise-Marie Dembry, MD, FACP, MS, MBA, FIDSA, BS
Diane Krause, MD, PhD
Matthew Bizzarro, MD
Joseph Craft, MD
Jesse Rinehart, PhD
362Publications
12,739Citations
Spherocytosis, Hereditary
Elliptocytosis, Hereditary
Erythropoiesis
Hydrops Fetalis
Anemia, Sickle Cell
Pyruvate Kinase
Publications
2025
Codanin-1, defective in congenital dyserythropoietic anemia I (CDA-I), regulates erythroid differentiation
Bosques L, Modepalli S, Nagarajan A, Tang C, Martínez-Morilla S, Rahman N, Mehta S, Krause D, Tamary H, Gallagher P, Hattangadi S, Kupfer G. Codanin-1, defective in congenital dyserythropoietic anemia I (CDA-I), regulates erythroid differentiation. Annals Of Hematology 2025, 1-15. PMID: 41028447, DOI: 10.1007/s00277-025-06540-6.Peer-Reviewed Original ResearchConceptsCodanin-1CDA-ICDA-I.Gene regulatory regionsCongenital dyserythropoietic anemia IHigh-throughput sequencingAbnormal morphologyErythroid differentiationGlobal gene expressionErythroid progenitor developmentBone marrow erythroblastsHuman K562 cellsAutosomal recessive disorderErythroid cell differentiationRegulatory regionsChromatin immunoprecipitationAHSP geneCDAN1 geneErythroid genesMarrow erythroblastsIneffective erythropoiesisPeripheral bloodGene expressionHuman CD34GenesComprehensive phenotypic and proteomic analyses of human reticulocyte maturation
Leduc M, Papoin J, Yan H, Le Gall M, Nemer W, Hillyer C, Gallagher P, Gautier E, Mohandas N, Blanc L. Comprehensive phenotypic and proteomic analyses of human reticulocyte maturation. Blood Red Cells & Iron 2025, 1: 100012. DOI: 10.1016/j.brci.2025.100012.Peer-Reviewed Original ResearchCitationsConceptsStages of reticulocyte maturationReticulocyte maturationExpression of surface proteinsMature reticulocytesProteomic analysisSurface proteinsNascent reticulocytesExtensive membrane remodelingClasses of proteinsComparison of proteomesMembrane remodelingOrganelle clearanceFluorescence-activated cell sorting analysisMembrane proteinsStages of erythropoiesisMature erythrocytesCell sorting analysisProteomic profilingMolecular mechanismsProteinDensity gradient separationHealthy human bone marrowProcess remodelingProteomicsSorting analysisA mouse model for hemoglobin SC disease recapitulates characteristic human pathologies
Zhai J, Papizan J, Yao Y, Arnold E, Yu J, Tran T, Geiger N, Gollamudi J, Little D, Jadeja R, John J, Khalighifar A, Mayberry K, McEvoy J, Rooney R, Venkataraman K, Vu H, Zhang J, Dyer M, Gallagher P, Hyacinth H, Janke L, Martin P, Ni M, Xu J, Yen J, Zheng Y, Weiss M, Pruett-Miller S. A mouse model for hemoglobin SC disease recapitulates characteristic human pathologies. Blood Advances 2025 PMID: 40864227, DOI: 10.1182/bloodadvances.2025016793.Peer-Reviewed Original ResearchCitationsConceptsSickle cell diseaseLife-threatening groupB-globin geneMouse modelLack of animal modelsB-globinHemoglobin SC diseaseGroup of disordersHbSS miceHbSC diseaseGenome engineeringMouse strainsSC diseaseAnimal modelsCell diseaseMissense mutationsMouse counterpartMiceHuman pathologiesDiseaseGenesPathologyHuman ABMI1 regulates human erythroid self-renewal through both gene repression and gene activation
McGrath K, Olsen J, Koniski A, Murphy K, Getman M, An H, Schulz V, Kim A, Zhang B, Carlson T, Papoin J, Blanc L, Kingsley P, Westhoff C, Gallagher P, Chou S, Steiner L, Palis J. BMI1 regulates human erythroid self-renewal through both gene repression and gene activation. Nature Communications 2025, 16: 7619. PMID: 40817093, PMCID: PMC12356964, DOI: 10.1038/s41467-025-62993-3.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSelf-RenewalErythroid precursorsProliferative capacityImmature erythroid precursorsExtensive proliferationCell cycle kineticsGene repressionMechanism of actionGene activationRed blood cellsHuman erythroblastsBMI1 overexpressionBMI1 inhibitionTarget genesClinical useRepressive histone marksRepressive histone modificationsMonoclonal antibodiesCycle kineticsBlood cellsBMI1Regulation of cholesterol homeostasisClinical purposesErythroblastsHistone marksThe Emerging Role of Genome Sequencing in Newborn Screening
Chaudhari B, Burns W, Messick E, Gallagher P. The Emerging Role of Genome Sequencing in Newborn Screening. Clinics In Perinatology 2025, 52: 609-628. PMID: 40850719, DOI: 10.1016/j.clp.2025.06.008.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsNewborn Screening and Perinatal Genetic Diagnostic Testing
Gallagher P, Kemper A. Newborn Screening and Perinatal Genetic Diagnostic Testing. Clinics In Perinatology 2025, 52: xvii-xix. PMID: 40850721, DOI: 10.1016/j.clp.2025.06.013.Peer-Reviewed Original ResearchWelcome to Blood Red Cells & Iron
Gallagher P, Silvestri L. Welcome to Blood Red Cells & Iron. Blood Red Cells & Iron 2025, 1: 100008. DOI: 10.1016/j.brci.2025.100008.Peer-Reviewed Original Research
2024
A pinch of salt to enhance preemie growth?
Steflik H, Pearlman S, Gallagher P, Lakshminrusimha S. A pinch of salt to enhance preemie growth? Journal Of Perinatology 2024, 45: 295-297. PMID: 39567649, DOI: 10.1038/s41372-024-02174-0.Peer-Reviewed Original ResearchCitationsAltmetricMouse Models of Hereditary Xerocytosis-Associated PIEZO1 Mutations Reveal Genotype-Phenotype Differences in Hematological Defects and Iron Loading
Finberg K, Peres Diaz L, Shan P, Chua E, Lalwani K, Gallagher P. Mouse Models of Hereditary Xerocytosis-Associated PIEZO1 Mutations Reveal Genotype-Phenotype Differences in Hematological Defects and Iron Loading. Blood 2024, 144: 3851-3851. DOI: 10.1182/blood-2024-203740.Peer-Reviewed Original ResearchConceptsRed cell distribution widthHereditary xerocytosisSpleen weight/body weight ratioRed blood cell countMean corpuscular volumeCompared to wild-typeHematological defectsMouse modelHeart weight/body weight ratioWild-typeIron loadingComplete blood count analysisRed blood cell turnoverSerum transferrin saturationC57BL/6 genetic backgroundSerum hepcidin levelsLiver iron loadingYoung adult miceGenotype-phenotype differencesCell distribution widthMean corpuscular hemoglobinGain-of-function mutationsBlood count analysisNon-heme iron concentrationsRed cell indicesHEXIM1 Regulates Early Erythropoiesis and Participates in Multiple Complexes in Erythroid Cells
Rahman N, Abid D, Lv X, Murphy K, Getman M, McGrath K, Gallagher P, Narla M, Blanc L, Palis J, Mello S, Steiner L. HEXIM1 Regulates Early Erythropoiesis and Participates in Multiple Complexes in Erythroid Cells. Blood 2024, 144: 536. DOI: 10.1182/blood-2024-209259.Peer-Reviewed Original ResearchConceptsRNA polymerase IIErythroid gene expressionGene expressionTerminal erythroid maturationEarly erythropoiesisErythroid cellsErythroid maturationRegulation of gene expressionProgenitor cellsImpaired erythroid differentiationRNAPII pausingGenomic contextPolymerase IIRepress transcriptionSteady-state erythropoiesisErythroid progenitor cellsCD34+ HSPCsRegulatory domainBinding partnersErythropoiesis in vivoBlood cell countColony-forming cellsLow red blood cell countSubnuclear bodiesErythroid progenitor differentiation
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