1999
Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex
Anton E, Kreidberg J, Rakic P. Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex. Neuron 1999, 22: 277-289. PMID: 10069334, DOI: 10.1016/s0896-6273(00)81089-2.Peer-Reviewed Original ResearchConceptsCerebral cortexNeuronal migrationNeuron-glial interactionsΑv integrin receptorsRadial glial cellsRadial glial fibersCortical neuronsGlial cellsAbnormal layeringLaminar organizationGlial fibersCortexNeuronsSpecific cell-cell recognitionAlpha3beta1 integrinIntegrin receptorsIntegrin geneIntegrinsTargeted mutationsIntegrin functionCorticogenesisReceptors
1997
Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration
Cameron R, Ruffin J, Cho N, Cameron P, Rakic P. Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration. The Journal Of Comparative Neurology 1997, 387: 467-488. PMID: 9373008, DOI: 10.1002/(sici)1096-9861(19971103)387:4<467::aid-cne1>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsRadial glial cell processesGlial cell processesMultiple brain regionsNeuronal cell migrationAstrocyte-astrocyteSubventricular zoneImmunofluorescent localization studiesAstroglial cellsNeuron-neuronCerebellar astrocytesBrain regionsMorphologic featuresNeuronal migrationMonoclonal antibodiesImmunoreactivityAntibodiesNeuronsAstrocytesCell migrationPresent studyDevelopmental expressionPattern of distributionCell migration processesRole of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex.
Anton E, Marchionni M, Lee K, Rakic P. Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development 1997, 124: 3501-10. PMID: 9342043, DOI: 10.1242/dev.124.18.3501.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell CommunicationCell MovementCerebral CortexCulture TechniquesFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGlycoproteinsNerve Growth FactorsNerve Tissue ProteinsNeuregulinsNeurogliaNeuronsRatsRats, Sprague-DawleyReceptor, ErbB-2Receptors, Nerve Growth FactorSignal TransductionConceptsRadial glial developmentRadial glial cellsBrain lipid-binding proteinCerebral cortexGlial cellsNeuronal migrationGlial developmentRadial glial cell functionGlial growth factorGlial cell functionRadial glial fibersRadial glial fiber systemNeuronal cell migrationCortical neuronsGlial interactionsRadial gliaGlial fibersGlial moleculesCortexNeuronsGrowth factorErbB2 receptorCell functionDependent mannerCell migration
1994
Identification of membrane proteins that comprise the plasmalemmal junction between migrating neurons and radial glial cells
Cameron R, Rakic P. Identification of membrane proteins that comprise the plasmalemmal junction between migrating neurons and radial glial cells. Journal Of Neuroscience 1994, 14: 3139-3155. PMID: 8182462, PMCID: PMC6577439, DOI: 10.1523/jneurosci.14-05-03139.1994.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsMembrane proteinsCell-cell recognitionFocal adhesion plaquesApparent molecular massRadial glial cell processesNeuronal cell migrationCerebellar glial cellsActin cytoskeletonGlial cell processesMicrotubule cytoskeletonNon-neural tissuesSurface microdomainsMembrane polypeptidesIndividual proteinsAdhesion plaquesProcess-bearing astrocytesIntact microtubulesAdult stageMolecular massCell migrationMigration eventsIntegrin subunitsJunctional complexes
1982
The Role of Neuronal-Glial Cell Interaction During Brain Development
Rakic P. The Role of Neuronal-Glial Cell Interaction During Brain Development. Dahlem Workshop Report 1982, 25-38. DOI: 10.1007/978-3-642-68466-1_4.Peer-Reviewed Original ResearchRadial glial cellsGlial cellsNeuronal-glial cell interactionsGlial-specific markersGlial cell classesRecent immunocytochemical studiesSite of originBrain abnormalitiesSynaptic terminalsGlial precursorsNervous systemPrimate brainGlial fibersImmunocytochemical studyBrain developmentDifferentiating neuronsCell classesBrain surfaceDegenerating cellsSpecific markersVentricular surfaceCellular mechanismsProliferative zonePossible involvementNormal developmental processes
1981
Neuronal-glial interaction during brain development
Rakic P. Neuronal-glial interaction during brain development. Trends In Neurosciences 1981, 4: 184-187. DOI: 10.1016/0166-2236(81)90060-6.Peer-Reviewed Original ResearchRadial glial cellsGlial cellsNeuronal-glial interactionsGlial cell classesPositioning of neuronsPeak of neurogenesisRecent immunocytochemical studiesImmature neuronsCerebellar cortexPrimate brainImmunocytochemical studyBrain developmentCell precursorsCell classesSpecific markersNeuronsNeuron tissueElectron microscopic analysisCellsNeurogenesisCortexBrainCoexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis
Levitt P, Cooper M, Rakic P. Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis. Journal Of Neuroscience 1981, 1: 27-39. PMID: 7050307, PMCID: PMC6564162, DOI: 10.1523/jneurosci.01-01-00027.1981.Peer-Reviewed Original ResearchConceptsGlial fibrillary acid proteinLast cell divisionCell divisionRadial glial cellsNeuronal cell lineAcid proteinCerebral ventricular zoneEmbryonic day 80Proliferative zoneGlial precursor cellsMitotic cycleCell typesPeak of neurogenesisPrecursor cellsCell linesVentricular zoneElectron microscopic levelFetal monkeysProliferative cellsGlial cellsSubventricular zoneOccipital lobePhenotypic expressionCytological compositionDistinct classes
1980
Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain
Levitt P, Rakic P. Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain. The Journal Of Comparative Neurology 1980, 193: 815-840. PMID: 7002963, DOI: 10.1002/cne.901930316.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinRadial glial cellsGlial cellsFibrillary acidic proteinBergmann glial cellsGlial fibersNeuronal elementsPial surfacePeroxidase-antiperoxidase immunohistochemical stainingAcidic proteinNeuronal migrationEmbryonic day 38Rhesus monkey brainSecond postnatal monthCentral nervous systemHorseradish peroxidase reaction productRadial fibersSpinal cordPostnatal monthBergmann glial fibersSubventricular zoneImmunohistochemical stainingAstroglial cellsCerebellar cortexImmunohistochemical localization
1979
A golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes
Schmechel D, Rakic P. A golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes. Brain Structure And Function 1979, 156: 115-152. PMID: 111580, DOI: 10.1007/bf00300010.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsCerebral wallSubventricular zoneOccipital lobeRadial fibersPial surfaceRadial glial fibersRapid Golgi methodMedial cerebral wallMonkey telencephalonCalcarine fissureCortical plateGolgi studyLateral ventricleProtoplasmic astrocytesLarge oval nucleiDay 365Ependymal cellsGlial fibersAstrocytesRhesus monkeysOlder ageDay 48Oval nucleiArrested proliferation of radial glial cells during midgestation in rhesus monkey
SCHMECHEL D, RAKIC P. Arrested proliferation of radial glial cells during midgestation in rhesus monkey. Nature 1979, 277: 303-305. PMID: 105294, DOI: 10.1038/277303a0.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsPial surfaceCerebral cortexGlial natureOccipital lobeTelencephalic wallEpendymal cellsGlial fibersRhesus monkeysNeuronal migrationCell classesAutoradiographic analysisVentricular surfaceAstrocytesTwo-thirdsMidgestationPresent studyCellsProliferationGestationPostnatalCerebrumCortexMonths